Beamline Facility Dean Chapman Science Director, Canadian Light - - PowerPoint PPT Presentation

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Beamline Facility Dean Chapman Science Director, Canadian Light - - PowerPoint PPT Presentation

Sep 23, 2022 256 likes •739 views

The Canadian Light Source and the Biomedical Beamline Facility Dean Chapman Science Director, Canadian Light Source University of Saskatchewan Plan Brief Overview of the Canadian Light Source Design of the Biomedical Imaging and Therapy

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The Canadian Light Source and the Biomedical Beamline Facility

Dean Chapman Science Director, Canadian Light Source University of Saskatchewan

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SLIDE 2

Plan

Brief Overview of the Canadian Light Source Design of the Biomedical Imaging and Therapy Beamlines

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SLIDE 3

CLS Timeline

September 27, 1999 – Groundbreaking ceremony February 26, 2001 – Building dedication ceremony September 18, 2002 – Booster ring commissioning complete December 9, 2003 – First synchrotron light detected October 22, 2004 – Official opening May 27, 2005 – First CLS user June 30, 2005 – Official completion of the CFI project

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SLIDE 4

Original Construction (7 beamlines) $141M Phase II (7 beamlines)

$52M

Phase III (7 beamlines & upgrade)

$68M

Isotopes Project $12M

Capital Investment to Date

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SLIDE 5

CLS Features

Canada’s national synchrotron facility One of the world’s first ~3 GeV synchrotrons

Superconducting RF cavity Canted insertion devices Hard X-rays from superconducting wigglers

Full spectrum of photon energies for spectroscopy (THz to hard X-rays) Other highlights: STXM, medical imaging, soft X-ray REIXS, soil science and mining applications

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SLIDE 6

CLS Layout

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SLIDE 7

Energy Range

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SLIDE 8

Users and User Visits

Prepared by Lavina Carter

78 195 282 393 447 577 619 755 24 46 95 125 156 208 219 238 97 386 566 757 911 1236 1295 1431 78 139 165 205 209 300 282 364 1100 1300 1500 1700 550 650 750 850 200 400 600 800 1000 1200 1400 1600 1800 2005 2006 2007 2008 2009 2010 2011 2012 2013 Users Users Groups User Visits New Users User Visits Target Users Target

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SLIDE 9

Peer Review Access

2009 2010 2011 2012

Number of shifts requested

1768 2675 3456 4410

Number of shifts allocated

1252 1816 2203 3168

Oversubscript ion

41% 47% 57% 39%

1 shift = 8 hours of beamtime 9

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SLIDE 10

User Base

Geographic Distribution 2008 2009 2010 2011 2012 Canada - SK 560 (46%) 590 (35%) 716 (30%) 1106 (38%) 1184 (36%) Canada - Other 554 (45%) 828 (49%) 1232 (52%) 1304 (44%) 1370 (42%) International 114 (9%) 275 (16%) 406 (17%) 532 (18%) 728 (22%)

Based on # of users (2012) Canada – SK: 44% Canada – Other: 35% International: 21% Based on shifts: 10

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SLIDE 11

Broad Range of Disciplines

100 200 300 400 500 600 700 800 2005 2006 2007 2008 2009 2010 2011 2012 Environmental and Earth Sciences Life Sciences Macromolecular Crystallography Material and Chemical Sciences unclassified

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Students and Postdocs

100 200 300 400 500 600 700 800 2008 2009 2010 2011 2012 Other Student Post Doctoral Fellow Research Associate Scientist Faculty

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Some CLS Stats

Opened for peer- reviewed users 2006 Beamlines producing publications in 2013 13 Funded beamlines 22 Publications in 2013 242* Shifts requested / allocated in 2013 4788 / 3077 Oversubscription factor 2013 1.56 Users/User visits 2013 883 / 1630 Publications/Beamline 19 Publications/100 shifts 5.5 Publications/User 0.28 Publications/User Visit 0.15 Publications/$1M Operating Cost 8.9 Beam energy 2.9 GeV Circumference 171 m Number of straight sections 12 Average current ~200 mA Top-up No Horizontal emittance 18.2 nm rad Facility employees 215 Phase I cost $173M (7 Phase I beamlines) Operating costs (2013) $28M

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SLIDE 14

Biomedical Imaging and Therapy (BMIT) Beamlines

Some design considerations based on proposed user programs

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SLIDE 15

Technology –

Synchrotron Biomedical Imaging Methods

Projection and CT

Absorption Imaging

  • Uses tunability

K-edge Subtraction

  • Uses tunability

In-Line Phase Contrast Imaging

  • Uses high source brightness (small source size)

Analyzer Based Imaging / Diffraction Enhanced Imaging / Multiple Image Radiography

  • Uses high source brightness (high intensity)
  • Grating (Talbot) Interferometry Imaging (in progress)
  • Uses brightness

High Resolution Imaging / Microtomography

  • Uses high source brightness (intensity & source size)
  • Can apply most of above imaging methods

in vivo tissues

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LOCATION, LOCATION, LOCATION

Western College of Veterinary Medicine Saskatoon Cancer Centre College of Medicine / Royal Univ Hospital City Hospital / Breast Health Centre CLS VIDO / InterVac Kinesiology Engineering

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SLIDE 17

Location

Small Animal Preparation Lab

Computer Lab

Dark- room Storage

Large Animal Prep Lab

User Change Room Shower Area

CLSI Life Science Lab 100 m2

SOE Control Room Mech. Assembly Elect.

  • Equip. /

Controls Human Prep

Insertion Device / Bend Magnet

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05B1-1 Beamline Overview

Source: Bending Magnet: White/Mono Beam Monochromator: Double Crystal Mono (Bragg) Spectral range: 8 – 40 keV (temp limit 15-40 keV) Resolving power (Mono): 1x10-4 Beam size: 240 mm (H) x 7 mm (V) @ 25 m White Beam Power: ~350 W (250 mA, 2.9 GeV)

  • Max. Power Density:

~2.3 W/mm2 (250 mA, 2.9 GeV)

  • Max. dose rate

using pink beam: ~4 Gy/min @ 250 mA @ 50 keV

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SLIDE 19

BMIT Superconducting Wiggler

4.3T max field 4.8cm period 25 full field poles 2 half field poles

  • 15kW @

250mA ring current

  • 30kW @

500mA

  • Highest

field to period ratio in world

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SLIDE 20

Photon Energy (keV) Brilliance (photons/sec/mrad2/0.1%bw)

1000 1011 100 10 1 1012 1013 1014 1015 1016

CLS Bend Magnet ESRF MRT CLS 4T CLS 3T ESRF Img

BMIT Beamlines – one bend & one wiggler

CLS Bend B0 = 1.354T Ec = 7.57keV BMIT Superconducting Wiggler (Bukder, Novosibirsk, Russia) B0 = 1.0 to 4.3T lu=4.8 26 effective poles (25 full, 2 half) K = 4.5 to 19.3 Ec = 5.6 to 24.0

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Wiggler Beamline Filter Assembly

Filter assembly had shipping plate and bolts on bottom Missed in final assembly Beam hit plate and bolt –

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Choice of Wiggler Characteristics

Imaging

20 to 100keV High flux

Microbeam Radiation Therapy (MRT)

High dose rate @ 100keV

Wiggler

Need for high x-ray energies => high B Need for high flux => large number of poles Efficiency => small period Front end power limitation of ~30kW @ 500mA

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SLIDE 23

Insertion Device Optimization for Imaging and MRT

Spectral Surface Dose Rate (Gy/s/keV) @100keV 150 100 50 00 2 4 6 8 10

Continuous Period Values Discrete Period Values

Wiggler Field (T)

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BMIT Instrumentation

Unique Large Positioning Systems

Large Animal Positioning System (LAPS) Microbeam Radiation Therapy Lift (MRT Lift) Detector Positioning Systems (POE2 and SOE)

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Insertion Device SOE Hutch

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Unique in the world: the large animal positioning system

  • n the Biomedical Imaging and Therapy (BMIT) Beamline

Denise Miller, BMIT Systems Analyst George Belev, BMIT Beamline Scientist

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SLIDE 27

2.7 m (V) Up Up 13 13º Down Down 7.5 7.5º SOE SOE-1 POE POE-3 0.7 m (V) 4.8 m (V) 2.7 m (V) LAPS Camera Posit. KES

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SLIDE 28

Large Animal Positioning System

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Large Animal Positioning System

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Large Animal Positioning System

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MRT Down

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MRT Up

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MRT Lift in operation…

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SOE Detector Holder

  • Positions detector for

all imaging modes

  • KES
  • DEI/MIR
  • In-Line Phase
  • …
  • Granite stand it front

holds DEI Analyzer

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SLIDE 35

Bend Magnet POE 2 Hutch

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SLIDE 36

imaging beam imaging beam ion chamber detector ~12.5m ~13m double crystal monochromator analyzer

  • bject

Analyzer Based Imaging / Diffraction Enhanced Imaging System

Side View Top View

Bend Magnet System POE1 & 2

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SLIDE 37

BMIT Lives!!

Mouse @ 41keV ~2mGy exposure 17 Dec 2008 Radiograph DEI Analyzer Top

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SLIDE 38
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SLIDE 39

POE 2 BM Analyzer and Detector Holder

Position detector for same modalities as in SOE DEI Analyzer in front of holder with analyzer in place

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Analyzer Based Imaging System @ BMIT BM

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imaging beam control beam control beam detector imaging beam ion chamber detector ~12.5m ~13m double crystal mono analyzer refractor

Analyzer Control System

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SLIDE 42

Si(4,4,0) @ 40keV

1 2 3 4

  • 1
  • 2
  • 3
  • 4

1.87mr 100° 80° 60° 40° 20° 120° 140° 160° 180° 0° Imaging Beam Rel. Intensity Control on Low Angle Side @ ½ Peak Control on High Angle Side @ ½ Peak

Location on Imaging Beam Rocking Curve (mr)

Refractor Angle (deg)

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SLIDE 43

Earliest Signs of Osteoarthritis…

DEI CT of Piglet Joints

Glendon Rhoades, Alan Rosenberg, Sheldon Wiebe, Chapman, et al DEI CT Refraction Image 40keV BMIT 05B1-1

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SLIDE 44

Conclusion

  • Unique opportunity and

environment for biomedical research

  • Very flexible facility –

“wind tunnel”

  • Training a new generation of scientists in

interdisciplinary research

  • Insertion Device beamline recently on-line
  • New concepts to expand utility of beamline
  • We have just started…
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SLIDE 45

Tomasz Wysokinski George Belev Adam Webb Denise Miller Ning Zhu David Cooper

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SLIDE 46

You can contact us at dean.chapman@usask.ca tomasz.wysokinski@lightsource.ca

BMIT is supported by:

Canada Foundation for Innovation Saskatchewan Cancer Agency Province of Saskatchewan Alberta Cancer Board Western Economic Diversification Breast Cancer Society of Canada SK Heart & Stroke Foundation University of Saskatchewan - SK Health Research Foundation College of Medicine Saskatoon Health Region Western College of Veterinary Medicine Royal Univ. Hospital Foundation College of Kinesiology City Hospital Foundation Department of Psychology Regina Qu'Apelle Health Region College of Nursing Hospitals of Regina Foundation College of Dentistry Canadian Cancer Society - SK College of Agriculture

Canadian Light Source

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SLIDE 47

Thank you!