Arg-ADNI Patients Flowchart Patients Invited Patients Followed - PowerPoint PPT Presentation

Arg-ADNI Patients’ Flowchart Patients Invited Patients Followed Patients Followed Patients Followed to ADNI (Baseline) (1 st year) (30 months) Nº= 73 Nº= 56 Nº= 50 Nº= 42/46 New Patients Healthy Controls Healthy Controls Healthy Controls Invited to ADNI Nº= 15 Nº= 14 Nº= 11 Nº= 6 1 Negativa 1 Negativa Patients Screened at FLENI Early MCI Early MCI Early MCI Nº= 60 Nº=12 Nº=9 Nº=6 1 Cancer - 1 Negativa 1 Negativa 1 Psiquiatrica Screening Failure Dropout Late MCI Late MCI Late MCI Nº= 7 Nº= 3 Nº= 16 Nº= 16 Nº=15 2 Claustrophobia 2 removed 1 Negativa 1 Psychiatric Disease inform.cons 1 Cancer 1 by 1 Adult ADHD distance/caregiver Dementia AD Dementia AD Dementia AD 2 without informant Nº=13 Nº=11 Nº=10 1 Institucionalizada 1 Negativa 1 Cancer

Arg-ADNI Results Baseline Follow-up Follow-up Total NPS MRI CSF PET PET Follow-up Follow-up Nº Ass A β -tau FDG PiB 1 year 30 month Healthy Controls 15 15 15 11 15 15 13 11 Early MCI 12 12 12 7 10 8 10 6 Late MCI 16 16 16 14 16 15 16 15 Dementia AD 13 13 13 8 12 9 11 10 40 53 50 TOTAL 56 56 56 50 42 (71%) (95%) (89%)

Arg-ADNI Publications  Published • Creation of the Argentina- Alzheimer’s Disease Neuroimaging Initiative . Marıa Julieta Russo, Gustavo Sevlever et al. Alzheimer’s & Dementia 2014:10 S84– S87. • Concordance Between 11C-PIB-PET and Clinical Diagnosis in a Memory Clinic . American Journal of Alzheimer’s Disease & Other Dementias 2015:30(6) 599 -606. • Cognitive reserve and Aβ1 -42 in mild cognitive impairment (Argentina- Alzheimer’s Disease Neuroimaging Initiative) . Paula Harris, Ricardo Allegri, et al. Neuropsychiatric Disease and Treatment 2015:11 2599 – 2604. • Predicting episodic memory performance using different biomarkers: results from Argentina . Julieta Russo, Ricardo Allegri et al. Neuropsychiatric disease and treatment. [In Press] • In development • Argentina Alzheimer’s disease neuroimaging initiative (arg-ADNI): Neuropsychology after one-year follow up . Patricio Chrem Mendez, Ricardo Allegri et al. • Functional assessment in Argentina-ADNI: comparison and diagnostic utility of the Everyday Cognition (ECog) versus Functional Assessment Questionnaire (FAQ) . Julieta Russo, Ricardo Allegri et al.

Arg-ADNI New projections • Follow-up 54 months, including PET-tau AV-1451 Follow-up 54 month Baseline Follow-up NPS MRI CSF PET PET-tau 54 month Ass A β -tau PiB AV-1451 Healthy Controls 15 13 Early MCI 12 8 Late MCI 16 15 Dementia AD 13 10 TOTAL 56 46