Anthelmintic resistance in Europe Cattle, sheep and horses - - PowerPoint PPT Presentation

▶

Apr 23, 2023 281 likes •455 views

Anthelmintic resistance in Europe Cattle, sheep and horses Presented by Anita Bottger on 13 June 2016 EWP member, CBG-MEB An agency of the European Union Contents Overview of the anthelmintic resistance situation in Europe - Cattle -

SLIDE 1

An agency of the European Union

Anthelmintic resistance in Europe

Cattle, sheep and horses

Presented by Anita Bottger on 13 June 2016 EWP member, CBG-MEB

SLIDE 2

Anthelmintic resistance in Europe 1

Overview of the anthelmintic resistance situation in Europe

Cattle
Horses
Sheep

SLIDE 3

Source : De Graeve Vlaams Diergeneeskundig Tijdschrift 2012 Anthelmintic resistance in Europe 2

SLIDE 4

Cattle

Anthelmintic resistance in Europe 3

SLIDE 5

Resistance

Cooperia oncophora Ostertagia ostertagi

Anthelmintic resistance in Europe 4

Typical nodules in abomasum: hyperplasia and distention of gastric glands

SLIDE 6

Ivermectin resistance In 2006 Cooperia oncophora and/ or Ostertagia

stertagi source Demeler et al

2008

n= 7 n= 9 n= 6

Reduced efficacy (FECR< 95%

n day 21)

Belgium 5/ 7 farms* Sweden 4/ 5 farms Germany 5/ 8 farms* * lower CI< 90% in all farms

SLIDE 7

Cooperia

ncophora

Ivermectin resistance Monitoring resistance development . one farm

Source El Abdellati et al (2010)

FECRT

SLIDE 8

Horses

Anthelmintic resistance in Europe 7

SLIDE 9

Resistance in Europe Parascaris equorum Cyathostominae

Anthelmintic resistance in Europe 8

ivermectin (reports

throughout Europe)

moxidectin (reports)
Benzimidazoles frequent
pyrantel (some reports)
ivermectin/ moxidectin?

Source: Von Samson-Himmelstjerna, 2011, Nielsen 2014, Matthews 2014

SLIDE 10

Sheep

Anthelmintic resistance in Europe 9

SLIDE 11

Resistant helminths

Teladorsagia spp,
Haemonchus contortus,
Trichostrongylus spp
Fasciola hepatica

Anthelmintic resistance in Europe 10

SLIDE 12

Anthelmintic resistance in Europe 11

Resistance in sheep helminths in Europe

Benzimidazoles
Levamisole

Increased resistance to macrocyclic lactones

Ivermectin (mainly)
Doramectin
Moxidectin
Multi-drug resistant helminths
Triclabendazole (flukicide)
Source Papadopoulos 2012

SLIDE 13

Triclabendazole resistance in Fasciola hepatica in the

Netherlands. Based on necropsy

and FECRT Monitoring is voluntary: underestimation

Source V.d. Brom, GD Deventer

SLIDE 14

conclusion

Anthelmintic resistance in Europe 13

Resistance can spread very quickly within a wormpopulation
Reports on resistance situation used small numbers of farms
Monitoring program in entire Europe?

SLIDE 15

Thank you for your attention

European Medicines Agency

30 Churchill Place • Canary Wharf • London E14 5EU • United Kingdom

Telephone + 44 (0)20 3660 6000 Facsim ile + 44 (0)20 3660 5555 Send a question via our w ebsite www.ema.europa.eu/ contact