Administrative Supplements for Development of Risk-Stratified Cancer - - PowerPoint PPT Presentation

Administrative Supplements for Development of Risk-Stratified Cancer Survivorship Care Algorithms

NOT-CA-20-038

Division of Cancer Control and Population Sciences April 7, 2020

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Using WebEx and Webinar Training Logistics

▪ ▪ ▪ ▪ All lines will be in listen-only mode Submit questions at any time during the

• presentation. Type into the Q&A Panel and

select Host A moderator will ask the question on your behalf during the Q&A portions of the training This training webinar is being recorded and will be posted at a later date

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Webinar presenters

Michelle Mollica, PhD, MPH, RN, OCN Program Director, Healthcare Delivery Research Program Lisa Gallicchio, PhD Program Director, Epidemiology and Genomics Research Program

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1. Background 2. Supplement notice details 3. Questions

▪ ▪ Note: questions about specific projects will not be addressed Note: questions about COVID-19 supplements will not be addressed. Please see: https://grants.nih.gov/policy/natural- disasters/corona-virus.htm

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Background

Cancer Survivors:

Estimated prevalence from 1975 to 2040 by age (in millions)

5 10 15 20 25 30

1975 1980 1985 1990 1995 2000 2005 2010 2015 2020 2025 2030 2035 2040

Millions

85+ 75-84 65-74 50-64 < 50

2040, 26.1M 2016, 15.5 M 1975, 3.6 M

Source: Bluethmann, Mariotto & Rowland, CEBP 2016

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Survivorship Care After Active Treatment

Prevention/ surveillance of recurrence and new cancers Health promotion/ preventive care Surveillance/ management of effects of cancer and its treatment

Institute of Medicine. From cancer patient to cancer survivor: Lost in transition. Washington, DC: Institute of Medicine; 2005.

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Risk-stratified Survivorship Care

▪ Follow-up care pathways for survivors tailored based on risk for specific factors, including symptom burden, recurrence, subsequent malignancies, functional impairments

Low Risk Moderate Risk High Risk

Shorter-term transition to non-oncology providers Intermediate transition to non-oncology providers Long-term follow-up led mostly by

• ncology specialists

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Supplement Notice Details

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Administrative Supplements for Development of Risk- Stratified Cancer Survivorship Care Algorithms

▪ ▪ Goal: to stimulate research focused on the development and/or validation of risk-stratification algorithms that categorize survivors into meaningful risk-stratified groups to inform appropriate follow-up care NCI is seeking supplement applications that propose methodological approaches to identify individuals within each group

NOT-CA-20-038 Receipt date: May 15, 2020

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Eligibility

▪ ▪ ▪

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▪ Administrative supplement applications are limited to current NCI- funded projects Applicants must hold an active eligible grant (R01, U01, R37, P01, U19, UM1) Supplements must support work within the scope of the parent award

Can confirm this with your Program Director

Please see NOT-CA-20-038 for details on application process

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Important Considerations

▪ ▪ ▪

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Applicants should utilize existing parent study data alone or in conjunction with data from other sources (e.g., electronic medical records, cancer registry, and/or claims data) Supplement is focused on adult cancer survivors, including adult survivors of childhood cancers Applicants may propose a single or multiple cancer types

If focusing on one cancer type, application should address how this approach may serve as prototype for other cancers

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Budget

▪ ▪ ▪ Budgets should not exceed more than $150,000 in total costs Supplement project must be within the currently approved project period for the existing parent award Requests for no-cost extensions to accommodate a supplement will not be permitted

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Review process

▪ ▪ ▪ ▪ ▪ NCI will conduct reviews of submitted applications and will consider: Scientific merit of the proposed study Innovation of the proposed study Potential of the project to develop and/or validate a risk stratified algorithm Potential of developed algorithm to be utilized to inform care pathways for survivorship care

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Tips for Applicants

▪ ▪ ▪ ▪ Review NOT-CA-20-038 carefully for instructions Application Due Date: May 15, 2020 Webinar and FAQ will be posted on our website: https://healthcaredelivery.cancer.gov/media Connect with us early Michelle Mollica, PhD, MPH, RN, OCN Email: michelle.mollica@nih.gov Lisa Gallicchio, PhD Email: Lisa.gallicchio@nih.gov

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Questions?

Please type your questions in the Q & A section on WebEx

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