Acknowledgement Until late 20 century OA is traditionally - - PowerPoint PPT Presentation

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Jan 17, 2023 180 likes •245 views

Professor Yin Xiao, IHBI, QUT Acknowledgement Until late 20 century OA is traditionally considered a wear and tear disease OA knee degradation: an inevitable result of load Causes of osteoarthritis Meta etabol olic O c OA

SLIDE 1

Acknowledgement

Professor Yin Xiao, IHBI, QUT

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Until late 20 century OA is traditionally considered a “wear and tear” disease

OA knee degradation: an inevitable result of load

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Causes of osteoarthritis

Primary OA Secondary OA

Genetics Gender Old age Injuries

“Meta etabol

lic O

c OA” another

ther p

phenot notype? e?

Obesity
High Blood

Pressure

High Lipid Levels
Insulin Resistance

Although the final outcome is OA, molecular mechanisms leading to degradation could be different.

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LOOMING QUESTION: How to Decrease osteoarthritis Risk in ~over a billion adults worldwide currently obese?

Need a mechanistic approach to identify targets and strategies to break obesity-OA links

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Our lab studies different aspects of

steoarthritis (OA)
1. Prevention: Identifying risk factors eg: Obesity, Injury,

Metabolic syndrome and Dietary

Cholesterol & OA
Food and OA: “CartiFit”
2. Disease mechanisms: Basic biology, microRNAs, cell

interactions, trans-differentiation etc.

3. Early disease treatment: Disease modifying drugs
4. Imaging: MRI, NIR and 3D confocal
5. Late disease treatment: Cartilage engineering and