Acknowledgement Until late 20 century OA is traditionally - PowerPoint PPT Presentation

Jan 17, 2023 •180 likes •239 views

Professor Yin Xiao, IHBI, QUT Acknowledgement Until late 20 century OA is traditionally considered a wear and tear disease OA knee degradation: an inevitable result of load Causes of osteoarthritis Meta etabol olic O c OA

Professor Yin Xiao, IHBI, QUT Acknowledgement
Until late 20 century OA is traditionally considered a “wear and tear” disease OA knee degradation: an inevitable result of load
Causes of osteoarthritis “Meta etabol olic O c OA” Secondary OA Primary OA another other p phenot notype? e? Genetics Injuries Gender Old age - Obesity - High Blood Pressure - High Lipid Levels - Insulin Resistance Although the final outcome is OA, molecular mechanisms leading to degradation could be different.
LOOMING QUESTION: How to Decrease osteoarthritis Risk in ~over a billion adults worldwide currently obese? Need a mechanistic approach to identify targets and strategies to break obesity-OA links
Our lab studies different aspects of osteoarthritis (OA) 1. Prevention: Identifying risk factors eg: Obesity, Injury, Metabolic syndrome and Dietary Cholesterol & OA • Food and OA: “CartiFit” • 2. Disease mechanisms: Basic biology, microRNAs, cell interactions, trans-differentiation etc. 3. Early disease treatment: Disease modifying drugs 4. Imaging: MRI, NIR and 3D confocal 5. Late disease treatment: Cartilage engineering and stem cell therapy

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