SLIDE 7 7/2/2020 7
Frequency of Child Behavioral, Developmental or Psychiatric Conditions
Characteristic ASD N (%) DD N (%) POP N (%) P-value ADHD 52 (7.8%) 65 (7.1%) 5 (0.6%) <.001 Behavioral problems 104 (15.6%) 81 (8.9%) 18 (2.0%) <.001 Cognitive delay 5 (0.8%) 2 (0.2%) 2 (0.2%) .157 Feeding difficulties 48 (7.2%) 34 (3.7%) 22 (2.5%) <.001 Motor delay 127 (19.0%) 138 (15.1%) 11 (1.2%) <.001 Psychiatric disorders 25 (3.7%) 20 (2.2%) 4 (0.5%) <.001 Sensory disorders 188 (28.1%) 99 (10.8%) 9 (1.0%) <.001 Sleep problems 43 (6.4%) 24 (2.6%) 5 (0.6%) <.001 Speech delay 426 (63.8%) 525 (57.4%) 76 (8.6%) <.001
Levy et al., The Journal of Pediatrics, 205: 202-209, 2019
Results: Weight-Related Associations
Association between Maternal Pre-Pregnancy Weight Status and Child Weight Status
Kral et al., Autism, 2019 Maternal prepregn. weight status Unadjusted
status
demographic covariates
maternal covariates
status, demographic, maternal covariates
status, demographic, maternal, birth covariates OR (95% CI) P OR (95% CI) P OR (95% CI) P OR (95% CI) P OR (95% CI) P OR (95% CI) P OW/OB vs. UW/NW 2.43 (2.00, 2.96) <.001 2.38 (1.96, 2.90) <.001 2.40 (1.95, 2.95) <.001 2.32 (1.88, 2.87) <.001 2.33 (1.89, 2.87) <.001 2.00 (1.57, 2.53) <.001
After controlling for all covariates, mothers with pre-pregnancy obesity were 2 times more likely to have a child with obesity.
Association between Maternal Gestational Weight Gain (GWG) and Child Weight Status
GWG Unadjusted
- Adj. for case status
- Adj. for case status
& demographic covariates
& maternal covariates
status, demographic & maternal covariates
status, demographic, maternal, & birth covariates OR (95% CI) P OR (95% CI) P OR (95% CI) P OR (95% CI) P OR (95% CI) P OR (95% CI) P < IOM vs. > IOM 0.77 (0.56, 1.05) .095 0.75 (0.55, 1.03) .075 0.66 (0.47, 0.92) .016 0.78 (0.57, 1.07) .118 0.69 (0.49, 0.96) .029 0.77 (0.54, 1.09) .144 < IOM vs. = IOM 1.15 (0.83, 1.60) .393 1.11 (0.80, 1.55) .522 0.96 (0.67, 1.36) .799 1.14 (0.82, 1.58) .452 0.98 (0.69, 1.40) .928 1.01 (0.70, 1.46) .958 > IOM vs. = IOM 1.51 (1.19, 1.90) .001 1.48 (1.17, 1.87) .001 1.45 (1.14, 1.84) .003 1.46 (1.15, 1.85) .002 1.43 (1.13, 1.83) .004 1.32 (1.02, 1.69) .033
When controlling for case status, mothers who exceeded the GWG recommendations were 1.5 times more likely to have a child with obesity.
Kral et al., Autism, 2019
Frequency of Rapid Weight Gain Across Groups
ASD DD POP 10 20 30 40 50
44% 36% 33% P = 0.004
Rapid Weight Gain (% yes) Change in weight-for-age z-scores from birth to 6 months > 0.67 SD
Kral et al., Autism, 2019
Association between Rapid Weight Gain and Child Weight Status
Rapid weight gain Unadjusted
demographic covariates
covariates
demographic & maternal covariates
demographic, maternal, birth covariates OR (95% CI) P OR (95% CI) P OR (95% CI) P OR (95% CI) P OR (95% CI) P ASD: Yes vs. no 2.56 (1.60, 4.08) <0.001 2.60 (1.58, 4.27) <0.001 2.54 (1.58, 4.09) <0.001 2.65 (1.60, 4.41) <0.001 3.47 (1.85, 6.51) <0.001 DD: Yes vs. no 1.24 (0.83, 1.85) 0.302 1.30 (0.84, 2.00) 0.232 1.25 (0.83, 1.88) 0.286 1.32 (0.85, 2.05) 0.209 1.53 (0.92, 2.55) 0.098 POP: Yes vs. no 1.38 (0.88, 2.17) 0.158 1.44 (0.88, 2.35) 0.146 1.24 (0.78, 1.98) 0.363 1.26 (0.76, 2.09) 0.376 2.85 (1.44, 5.64) 0.003
Children w/ASD and rapid weight gain had 3.5 times greater odds of developing
- besity after controlling for all covariates.
Kral et al., Autism, 2019
37 38 39 40 41 42