3D printing in a pharmaceutical setting Johan Peter Btker - - PowerPoint PPT Presentation

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Apr 29, 2023 144 likes •417 views

U N I V E R S I T Y O F C O P E N H A G E N 3D printing in a pharmaceutical setting Johan Peter Btker Pharmaceutical Technology and Engineering Section Department of Pharmacy University of Copenhagen D E P A R T M E N T O F P H A R M A C

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3D printing in a pharmaceutical setting

Johan Peter Bøtker Pharmaceutical Technology and Engineering Section Department of Pharmacy University of Copenhagen

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Possibilities with the 3D printing techniques

D E P A R T M E N T O F P H A R M A C Y

3D printing is applied in industries such as food, aerospace, automotive, jewelry, military, medical and dental. It is often used for rapid prototyping but within the aerospace industry it is used for actual production of final parts. The possibility to modify the design of a given part at will is a huge benefit for production. Within the pharmaceutical industry the ability to play with e.g. surface area and shape in general may provide interesting possibilities.

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Possibilities with the 3D printing techniques

D E P A R T M E N T O F P H A R M A C Y

3D printing aka solid free-form technology (SFF), rapid prototyping (RP) and additive manufacturing (AM). 1986 Charles Hull field first stereolitographic patent alongside starting the company “3D systems” and developing the .STL file format. 1990 Fused deposition modeling (FDM) was developed by Scott Crump at Stratasys. 1993 MIT Professors Emanuel Sachs and Michael Cima patented first device named ”3D printer” that could print plastic, metal and ceramic parts. 3D printing enables more flexible manufacturing. Thus may also enable more flexible manufacturing of pharmaceuticals. Aprecia Pharmaceuticals have recently received FDA approval for a 3D printed orally disintegrating tablet and have started production.

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Introduction to 3D printing techniques

D E P A R T M E N T O F P H A R M A C Y

3D printing can be achieved using various techniques such as:

Stereolitography (SLA) Inkjet printing

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Introduction to 3D printing techniques

D E P A R T M E N T O F P H A R M A C Y

Selective laser sintering (SLS)

Fused Deposition modeling (FDM)

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Possibilities with the 3D printing techniques

D E P A R T M E N T O F P H A R M A C Y

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Possibilities with the 3D printing techniques

D E P A R T M E N T O F P H A R M A C Y

The 3D printing technique can facilitate the production of highly complex formulations.

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Possibilities with the 3D printing techniques

D E P A R T M E N T O F P H A R M A C Y

Thus the 3D printing technique can facilitate the production of highly complex formulations that has a unique dissolution profile.

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Possibilities with the 3D printing techniques

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Possibilities with the 3D printing techniques

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Possibilities with the 3D printing techniques

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Possibilities with the 3D printing techniques

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Activities within 3D printing

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3D printed implants containing NF, HA and PLA.

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U N I V E R S I T Y O F C O P E N H A G E N U N I V E R S I T Y O F C O P E N H A G E N D E P A R T M E N T O F P H A R M A C Y

Activities within 3D printing

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3D printed implants containing NF, HA and PLA.

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U N I V E R S I T Y O F C O P E N H A G E N U N I V E R S I T Y O F C O P E N H A G E N D E P A R T M E N T O F P H A R M A C Y

Activities within 3D printing

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3D printed implants containing NF, HA and PLA.

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U N I V E R S I T Y O F C O P E N H A G E N U N I V E R S I T Y O F C O P E N H A G E N D E P A R T M E N T O F P H A R M A C Y

Activities within 3D printing

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3D printed oral formulations.

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U N I V E R S I T Y O F C O P E N H A G E N U N I V E R S I T Y O F C O P E N H A G E N D E P A R T M E N T O F P H A R M A C Y

3D printing two compartment shell

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U N I V E R S I T Y O F C O P E N H A G E N U N I V E R S I T Y O F C O P E N H A G E N D E P A R T M E N T O F P H A R M A C Y

Activities within 3D printing

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3D printed oral formulations.

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U N I V E R S I T Y O F C O P E N H A G E N U N I V E R S I T Y O F C O P E N H A G E N D E P A R T M E N T O F P H A R M A C Y

3D printing of PLA shell

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3D printing PVA shell

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3D printing PVA shell

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3D printed oral powder formulations.

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3D printing two compartment shell

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3D printed oral SNEDDS formulations.

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U N I V E R S I T Y O F C O P E N H A G E N U N I V E R S I T Y O F C O P E N H A G E N D E P A R T M E N T O F P H A R M A C Y

3D printing two compartment shell

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U N I V E R S I T Y O F C O P E N H A G E N U N I V E R S I T Y O F C O P E N H A G E N D E P A R T M E N T O F P H A R M A C Y

3D printing two compartment shell

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3D printed oral SNEDDS formulations.

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U N I V E R S I T Y O F C O P E N H A G E N U N I V E R S I T Y O F C O P E N H A G E N D E P A R T M E N T O F P H A R M A C Y

3D printing two compartment shell

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3D printed oral SNEDDS formulations.

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Credits

Cecilie Rasch, Maria Høtoft Michaelsen, Anette Müllertz, Jukka Rantanen and Thomas Rades, University of Copenhagen

Daniel Markl and Axel Zeitler, University of Cambridge