1 Background 2 METHODS Types of studies: all Animal studies The - - PowerPoint PPT Presentation

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1 Background 2 METHODS Types of studies: all Animal studies The - - PowerPoint PPT Presentation

May 14, 2023 214 likes •385 views

1 Background 2 METHODS Types of studies: all Animal studies The effect of massage Participants: people of any age, Atrophic scars Keloid vs hypertrophic vs linear scars from various causes and vs healed by secondary intention various

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Background

2

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Types of studies: all Participants: people of any age, scars from various causes and various types of scars Interventions: moisturisers of any type Animal studies Atrophic scars Internal scarring or scarring of structures other than the skin The effect of massage Keloid vs hypertrophic vs linear vs healed by secondary intention

METHODS

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SEARCH STRATEGY

Database searches

  • Pubmed
  • Embase
  • CINAHL
  • Web of Science

Grey literature

  • https://clinicaltrials.gov/
  • www.anzctr.org.au – Australian and New Zealand Clinical Trials Registry, online registry of

clinical trials being undertaken in Australia, New Zealand and elsewhere.

  • www.controlled-trials.com - now called www.isrctn.com
  • www.opengrey.eu
  • http://www.cochranelibrary.com/about/central-landing-page.html

?

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Identification Screening Eligibility Included Records identified through systematic search (N = 1970) After removal of duplicates (N= 1419) Records screened (title and abstract) (N=1419) Records excluded that did not meet pre-defined criteria (N=1281) Full-text articles retrieved and assessed for eligibility (N = 73) Full-text articles excluded (N = 39) 7 studies included in meta-analysis – Imiquimod post excision of keloids 26 studies included in narrative synthesis – Effect of moisturisers Records identified via screening reference lists of eligible articles (N = 7) Full-text articles excluded following critical appraisal (N = 1) PRISMA Flow diagram outlining systematic review process

Refining the search

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Cosmesis

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Scar parameters

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Scar parameters

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Itch & Pain

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Outcomes measures

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Other considerations

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Final thoughts…

Quality Quality of

  • f

stud studies ies Outcome Outcome me meas asures ures Advers Adverse e eve events nts Imiquimod Imiquimod

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Summary of recommendations

Avoi Avoid Use Use Stud Studies ies needed needed Cons Consider ider

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References

15 [1] Klotz T, Kurmis R, Munn Z, Heath K, Greenwood J. Moisturisers in scar management following burn: A survey report. Burns. 2017;43(5):965-72. [2] Klotz T, Kurmis R, Munn Z, Heath K, Greenwood J. The effectiveness of moisturizers for the management of burn scars following severe burn injury: A systematic review

  • protocol. JBI Database of Systematic Reviews and Implementation Reports. 2014;12(11):212-20.

[3]Murdock J, Sayed MS, Tavakoli M, Portaliou DM, Lee WW. Safety and efficacy of a growth factor and cytokine-containing topical product in wound healing and incision scar management after upper eyelid blepharoplasty: A prospective split-face study. Clinical Ophthalmology. 2016;10:1223-8. [4] Baumann LS, Spencer J. The effects of topical vitamin E on the cosmetic appearance of scars. Dermatologic Surgery. 1999;25(4):311-5. [5] Jenkins M, Alexander JW, MacMillan BG, Waymack JP , Kopcha R. Failure of topical steroids and vitamin E to reduce postoperative scar formation following reconstructive

  • surgery. J Burn Care Rehabil. 1986;7(4):309-12.

[6] Chung VQ, Kelley L, Marra D, Jiang SB. Onion extract gel versus petrolatum emollient on new surgical scars: A prospective double-blinded study. Dermatologic Surgery. 2006;32(2):193-7. [7] Perez OA, Viera MH, Patel JK, Konda S, Amini S, Huo R et al. A comparative study evaluating the tolerability and efficacy of two topical therapies for the treatment of keloids and hypertrophic scars. Journal of Drugs in Dermatology. 2010;9(5):514-8. [8] Berman B, Frankel S, Villa A, Nouri K. A double-blind, prospective study evaluating the effectiveness of imiquimod 5% cream applied to post-surgical excisions on scar

  • cosmesis. Journal of the American Academy of Dermatology. 2005;52(3):P206

[9] Kwon SY, Park SD, Park K. Comparative effect of topical silicone gel and topical tretinoin cream for the prevention of hypertrophic scar and keloid formation and the improvement of scars. Journal of the European Academy of Dermatology and Venereology. 2014;28(8):1025-33. [10] Panabiere-Castaings MH. Retinoic acid int he treatment of keloids. J Dermatol Surg Oncol. 1988;14(11):1275-76. [11] Prado A, Andrades P , Benitez S, Umana M. Scar management after breast surgery: preliminary results of a prospective, randomized, and double-blind clinical study with aldara cream 5% (imiquimod). Plast Reconstr Surg. 2005;115(3):966-72. [12] Phillips TJ, Gerstein AD, Lordan V. A randomized controlled trial of hydrocolloid dressing in the treatment of hypertrophic scars and keloids. Dermatologic Surgery. 1996;22(9):775-8. [13] MEDUNSA. Scar study US/SL 3/2005 [Unpublished work]. 2005. [14] proDERM. Placebo controlled, double-blind study to test the efficacy of Bio-Oil against scars. [Unpublished work]. 2010. [15] Jackson BA, Shelton AJ. Pilot study evaluating topical onion extract as treatment for postsurgical scars. Dermatologic Surgery. 1999;25(4):267-9. [16] Nedelec B, Rachelska G, Parnell LK, LaSalle L. Double-blind, randomized, pilot study assessing the resolution of postburn pruritus. J Burn Care Res. 2012;33(3):398-406. [17] Hoeksema H, De Vos M, Verbelen J, Pirayesh A, Monstrey S. Scar management by means of occlusion and hydration: A comparative study of silicones versus a hydrating gel-cream. Burns. 2013;39(7):1437-48.