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!"#$%"$#&'()*+'+,-(.-(/01(&23("45( - PowerPoint PPT Presentation

Symposium Celebrating the 40th Anniversary of the Protein Data Bank, Cold Spring Harbor, NY, USA, October 29, 2011 !"#$%"$#&'()*+'+,-(.-(/01(&23("45( 6#+"5*2(7&"&()&28 ( 9$#"(:;"4#*%4(


  1. Symposium Celebrating the 40th Anniversary of the Protein Data Bank, Cold Spring Harbor, NY, USA, October 29, 2011 !"#$%"$#&'()*+'+,-(.-(/01(&23("45( 6#+"5*2(7&"&()&28 ( 9$#"(:;"4#*%4( (<45(!%#*==>(15>5&#%4(?2>@"$"5A(B&(C+''&A(DEA(F!E(&23(( G<H(I;#*%4A(I;#*%4A(!J*"K5#'&23(

  2. • C:\Dokumente und Einstellungen\All Users \Dokumente\Eigene Bilder\KW-dias \Yale_10.2005\reduced\Yale-07.jpg

  3. PSI:BIOLOGY

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  9. PSI:BIOLOGY h"&'6#53S(&(J5.(>5#\5#([+#(=#53*%@+2(+[(=#+"5*2(%#->"&''*K&.*'*"-(( i4j=SkkP&>].$#24&L]+#,kh"&'6#53T%,*kf"&']='l(

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  13. NP_247299.1 ( Methanococcus jannaschii ) NMR NMR/Crystal

  14. Backbone Dihedral Angles � and �

  15. NP_247299.1: cis / trans isomers of N103– P104 NMR chemical shifts: two conformations for 64–66 and 101–104

  16. NP_247299.1: segments 64–66 and 101–104 trans -P104 cis -P104

  17. PSI:BIOLOGY b2*0=%i/K#0=;%J/=%/0%f*0+120#5%J002)#120%2@% Proteins % OP#.45,;%2@%*0?02c0%5/K#0=;% ((o((((0$%4(3*\5#>*"-(+[('*,&23>(*>([+$23(*2(=#+"5*2(%#->"&'(( >2*0=%)2%`U(a%;)"*+)*",;% (>"#$%"$#5>(+[("45(CD!Z(&23(+"45#(6!?(%52"5#>]( ((o( (?2"5#5>@2,(#+'5([+#(/01(*2(>+'$@+2S(( (((((((((oo((<45(*352@"-(+[("45(.+$23('*,&23(*>(+^52(3*p%$'"("+(((( ((((((((%+2Q#L(.-(hT#&-(%#->"&''+,#&=4-(&'+25]( (((((((((oo((!%&#%*"-(+[(E=+T=#+"5*2(%#->"&'(>"#$%"$#5>]( (( '$4,;%2@%>2*0=%5/K#0=;%/=,01A,=%/0%3(H%;)"*+)*",;% Others lRDm%2@%4"2),/0;%[#X,%>2*0=%5/K#0=;%

  18. PSI:BIOLOGY J<i-6%Y !"#$%"#&"'"# Z% 89:% 89:eU"$;)#5%

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  22. Prion Proteins 1996 �

  23. PSI:BIOLOGY

  24. � <G � <%5224%/0%X#"/#0);%2@%.3"3Y6<6v<W6Z%

  25. mPrP[Y225A,Y226A](121–231) T � o ( 1 H)

  26. .3"3% 92=,5;u%.3"3CB6RkJ%%%%%%%%B%F% � 6 %w%VRT% � 6 %w%GRT% :6RQ% :6RQ% o6RS% :6RQ% o6RS% � 6% � 6% o6RS% � 6% � <% B6Rk% f6gD% � <% f6gD% � <% f6gD% (6gT% B6Rk% (6gT% B6Rk% � <% 86g6% 86g6% � <% 86g6% � <%

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