With Clostridium Difficile Infections: Observational Data Of The - PowerPoint PPT Presentation

Management Of Elderly Patients With Clostridium Difficile Infections: Observational Data Of The French Survey CLOdi Arnaud CAUPENNE, Gaetan GAVAZZI, Marc PACCALIN University of Poitiers, FRANCE Intergroupe GInGer

CONFLICT OF INTEREST DISCLOSURE I have no potential conflict of interest to report

BACKGROUND • First cause of nosocomial diarrhea • Incidence: 2.28/10000 hospitalized patients-day (national french study) Eckert, 2013 • Recurrence and mortality estimated respectively 10 to 30% and 5 to 40% Surawicz, 2015 ; Garey, 2008 ; Johnson, 2009 • Assessment of risk factors and therapeutic practices for severe CDI are heterogeneous. Abou Chakra, 2014 ; Le Guern, 2013 ; Surawicz, 2013 ; Debast, 2014

RECOMMANDATIONS ESCMID 2013

AIMS  To assess prognosis of elderly patients with CDI  To report observational data collected during hospitalization and therapeutic regimen regarding to the European recommendations

PATIENTS AND METHODS • French survey CLOdi: prospective observational multicentric study • Inclusions: hospitalized patients aged ≥75 with CDI • 70 investigators in 31 French hospital centers • Inclusion: between march 2016 and may 2017 • Online survey focused on clinical criteria of severity , and CDI therapeutic support • Systematic follow-up at 3 months

PRELIMINARY RESULTS Characteristics of the population • 260 patients • Mean age: 87.1 ± 5.5 [75-99] • Female: 65% • Coming from home (83%) and nursing home (17%) • CIRS-G score: 12.54 ± 6.4 [2-34] (comorbidities) • 71% hospitalized in the past 12 months • 60% treated with antibiotic in the last 3 months

RESULTS Characteristics of the infection • Nosocomial : 68.2% • At the time of diagnosis • Diarrhea: 88% • Antibiotic: 44% among 60.5% were stopped • Control measure • isolation precaution: 94.5%

SEVERITY 197 (75,7%) patients with at least one severity marker (ESCMID) N (%) Severity criteria Fever > 38,5°C 44 (16.9%) Rigors 8 (3.1%) Sepsis 12 (4.6%) Leucocyte count > 15 x 10 9 /L 74 (28.5%) Créatinine > 50% above the baseline 53 (20.4%) Albumin < 30 g/L 135 (51.9%) Kalemia < 3,5 mmol/L 52 (20%) Distension of large intestine > 6 cm 1 (0.4%) Pseudomembranous colitis 6 (2.3%) Septic shock 3 (1.2%) Ileus 6 (2.3%)

FIRST INTENTION TREATMENT [VALORE] 140 (51.2%) [VALORE] 120 (36.9%) Nbr patients 100 80 60 40 [VALORE] (10%) 20 [VALORE] (1.2%) 0 Metronidazol Vancomycin Fidaxomicin Association of antibiotics Antibiotics

EVOLUTION Mean duration of isolation precaution (days) 11.8 ± 9.73 [0-82] Mean duration of antibiotic therapy (days) 11.6 ± 5.78 [0-67] Healing 187 (71.9%) Surgery 1 (0.4%) Death 45 (17.3%) • Death during the antibiotic treatment 21 (8.1%) • Death after the infection 24 (9.2%) In-hospitalization recurrence 31 (11.9%)

CONCLUSION • Our study shows high rate of severe infection in older patients • Metronidazol is the first intention therapy in 51% cases • Rate of early recurrence and mortality are close to literature data • The results highlight the lack of adequacy between antibiotic used and the European guidelines

Thanks to investigators PARIS ALES TOURS NIORT Dr Moulias Dr Fraisse Pr Bernard Dr Kahlifa Pr Rouveix Dr Lamande DIEPPE Dr Greffe MONTPELLIER SAINT YVI Dr Suel Dr Breining Dr Terminet ORLEANS Dr Jestin Dr Durand-Gasselin Pr Jeandel Dr Bourgeois LANDERNEAU BORDEAUX Dr Merrien TREVOUX ANGERS BLOIS Dr Bourdel-Marchasson Dr Pietropaoli Dr Tremblay Nguyen Dr Geffroy Dr Dubos ANGOULEME Dr Marechal Dr Pignon Dr Friocourt Dr Jarry VENDEE DIJON NICE PERPIGNAN Dr Pelerin Pr Piroth Dr Turpin Dr Eden Dr Martin Dr Putot Dr Mondain Dr Silga Dr Fevrier Dr Arlaud Dr Decours AIX CHAMBERY Dr Guimard Dr Puigserver CLERMONT FERRAND Dr Forestier Dr Morier Dr Maulin Dr Dadet GRENOBLE Saint GALMIER ROUEN COLMAR Dr Pavese Dr Carriere Dr Renaudier Dr Dardalhon Pr Gavazzi Dr Guignery-Kadri Dr Hauler PLAISIR Dr Kloul ANNECY Dr Aribi SAINT ETIENNE Dr Piet LYON Dr Dascalita BELLEY Dr Federico ROCHEFORT Dr Bard Dr Gaujard Dr Chartier NIMES Dr Martin Gaujard DUNKERQUE Pr de Wazieres (invest) Dr Albrand CHATELLERA Dr Berode Dr Viala Maurice (invest) Dr Chala hayet ULT Dr Gazali