Kansas HEN 2.0 Collaborative Meeting November 18, 2015 Reducing - - PDF document

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Kansas HEN 2.0 Collaborative Meeting November 18, 2015 Reducing - - PDF document

Kansas HEN 2.0 Collaborative Meeting November 18, 2015 Reducing Clostridium Difficile and Improving Antimicrobial Stewardship WHATS THE POOPMMM...SCOOP?! Cheryl Ruble, MS, RN CNS Improvement Advisor, Cynosure Health 1 2014 Silver Award


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Kansas HEN 2.0 Collaborative Meeting November 18, 2015 1

2014 Silver Award Recipient

WHAT’S THE POOP…MMM...SCOOP?!

Cheryl Ruble, MS, RN CNS Improvement Advisor, Cynosure Health

1

Reducing Clostridium Difficile and Improving Antimicrobial Stewardship

2014 Silver Award Recipient

Objectives

Discuss the changing epidemiology of Clostridium Difficile Infection (CDI) in the US Discuss current strategies to prevent CDI Describe two specific strategies to reduce transmission of C. difficile in the healthcare setting Discuss tracking CDI, data collection & submission

2014 Silver Award Recipient

3

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Kansas HEN 2.0 Collaborative Meeting November 18, 2015 2

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C Diff and Antibiotic Stewardship

2014 Silver Award Recipient

Background

  • 2‐5% of healthy adults have C.

difficile colonization of the colon

  • 20‐40% of hospitalized adults are

colonized with C. difficile

2014 Silver Award Recipient

  • C. Difficile Infection (CDI)
  • Range from mild to severe
  • Incidence and severity have increased with dissemination of

BI/NAP1 isolates – Historically uncommon – epidemic since 2000 – Increased virulence

  • Increased toxin A and B production
  • Polymorphisms in binding domain of toxin B
  • Increased sporulation

– Increased resistance to fluoroquinolones

  • Higher MICs compared to historic strains and current non‐

BI/NAP1 strains – Early diagnosis and treatment are required to reduce morbidity/mortality

McDonald et al. N Engl J Med. 2005;353:2433‐41; Warny et al. Lancet. 2005;366:1079‐84 Stabler et al. J Med Micro. 2008;57:771–5; Akerlund et al. J Clin Microbiol. 2008;46:1530–3

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Kansas HEN 2.0 Collaborative Meeting November 18, 2015 3

2014 Silver Award Recipient

Cost of CDI in US

  • 336,000 hospitalizations annually
  • Aggregate hospital costs exceed $8.2 billion

annually

  • Patients with principal CDI diagnosis remain

hospitalized for 6.9 days at a cost of $10,100/stay – Patients with secondary CDI diagnosis remain hospitalized for 16.0 days at a cost of $31,500/stay.

  • CDI disproportionately affects the elderly

– CMS pays for 68% of CDI hospital stays

Lucado J, Gould C, Elixhauser A. Clostridium difficile infections (CDI) in hospital stays, 2009. HCUP Statistical

  • Brief124. January 2012. Rockville, MD: Agency for Healthcare Research and Quality. http://www.hcup‐

us.ahrq.gov/reports/statbriefs/sb124.pdf. Accessed December 27, 2011.

2014 Silver Award Recipient

  • C. difficile Hospital Epidemiology
  • Use of antibiotics is frequent
  • Environmental contamination by C. difficile is

common

– Spores are difficult to eradicate

  • Personnel carry C. difficile on their hands
  • Asymptomatic patients carry C. difficile

2014 Silver Award Recipient

Rise in CDI in hospitalized US patients

  • Retrospective analysis of 2.2 million adult patients discharged

from US hospitals from 2001‐2010

  • ICD‐9‐CM code for CDI
  • CDI was associated with significant resource use
  • 66% of patients were admitted emergently
  • >50% had a concomitant infectious diagnosis

Reveles KR, Lee GC, Boyd NK, Frei CR. The rise in Clostridium difficile infection incidence among hospitalized adults in the United States: 2001‐2010. AJIC 42 (2014);1028‐12

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Kansas HEN 2.0 Collaborative Meeting November 18, 2015 4

2014 Silver Award Recipient

Clostridium difficile infection

  • Incidence of CDI in hospitalized adults in US nearly doubled

from 2001‐2010

  • 4.5 CDI discharges /1,000 discharges in 2001
  • 8.2 CDI discharges/1,000 discharges in 2010
  • Death occurs in approximately 9% of hospitalized patients with

CDI

  • Mean cost per hospital stay is $24,400

Reveles KR, Lee GC, Boyd NK, Frei CR. The rise in Clostridium difficile infection incidence among hospitalized adults in the United States: 2001‐2010. AJIC 42 (2014);1028‐12

2014 Silver Award Recipient

Who/what may transmit C. diff in Hospital?

  • 1. Symptomatic patients
  • 2. Asymptomatic patients
  • 3. Healthcare workers
  • 4. Environment

2014 Silver Award Recipient

CDI Risk Factors

  • Antimicrobial exposure
  • Acquisition of C. difficile
  • Advanced age
  • Underlying illness
  • Immunosuppression
  • Tube feeds
  • ? Gastric acid suppression
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Kansas HEN 2.0 Collaborative Meeting November 18, 2015 5

2014 Silver Award Recipient

Patient related factors

  • Advancing age
  • >65 significantly higher risk
  • Immunity changes
  • Antibiotic exposure
  • Other medications e.g. gastric‐

acid suppressants

  • Comorbid illness
  • Frequent hospitalizations

2014 Silver Award Recipient

Silver tsunami

  • In 2000, persons >65 represent

13% of the US population

  • By 2030, this population will

grow to be 19% of the US population

2014 Silver Award Recipient

Antimicrobial use

Most important risk factor Clindamycin, fluoroquinolones and cephalosporins

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Kansas HEN 2.0 Collaborative Meeting November 18, 2015 6

2014 Silver Award Recipient

Changing molecular epidemiology

  • Emergent strain BI/NAP1/027
  • Severe outbreaks in Europe,

Canada and US

  • Prolonged toxin production,

increased duration of germination and increased sporulation

2014 Silver Award Recipient

Clostridium difficile primer

  • Gram positive, spore forming rod
  • Obligate anaerobe
  • Toxin A and Toxin B
  • Required to cause disease
  • Clostridium difficile infection (CDI, formerly

CDAD)

  • Most common cause of healthcare‐associated

diarrhea

  • Fecal‐oral transmission
  • Is also community‐associated

2014 Silver Award Recipient

Pathogenesis of CDI

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2014 Silver Award Recipient

Putting a face on CDI

2014 Silver Award Recipient

Got Data?

  • Baseline?

– 2010 – 3rd quarter 2015

  • Tracking…

2014 Silver Award Recipient

CDI Risk Factors

  • Antimicrobial exposure
  • Acquisition of C. difficile
  • Advanced age
  • Underlying illness
  • Immunosuppression
  • Tube feeds
  • ? Gastric acid

suppression

Major modifiable risk factors

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2014 Silver Award Recipient

Major Modifiable Risk Factors

2014 Silver Award Recipient

Major Modifiable Risk Factors

Acquisition of C. difficile Optimizing Environmental Cleaning and Hand Hygiene Antibiotic Exposure Antibiotic Stewardship

2014 Silver Award Recipient

Major Modifiable Risk Factors

Acquisition of C. difficile Antibiotic Exposure

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Kansas HEN 2.0 Collaborative Meeting November 18, 2015 9

2014 Silver Award Recipient

Tips on prevention of transmission

Early Recognition Early Precautions Hand Hygiene Environmental Cleaning

2014 Silver Award Recipient

Early Recognition: screening for CDI

2014 Silver Award Recipient

Is it Mine or Yours?

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2014 Silver Award Recipient

Lab Tests for CDI

  • 2014: NHSN requires reporting type of test used at your

facility for CDI reporting

  • PCR=90% sensitive, 96% specific
  • EIA significantly lower for detection

FV Tenover, JCM 48:3719, 2010

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2014 Silver Award Recipient

How to optimize specimen collection

Charts Tarts

2014 Silver Award Recipient

If it ain’t loose….it’s of no use

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Kansas HEN 2.0 Collaborative Meeting November 18, 2015 11

2014 Silver Award Recipient

If the sticks stand, the tests are banned

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2014 Silver Award Recipient

SHEA‐IDSA Guideline: CDI Case Definition

  • Diarrhea (≥3 loose stools in 24 hours)
  • Stool test positive for Clostridium difficile toxin or toxigenic

Clostridium difficile OR Colonoscopic evidence of pseudomembranous colitis

Cohen SH et al. Clin Infect Dis. 2010;31(5):431‐455.

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2014 Silver Award Recipient

SHEA/IDSA Compendium

  • Perform testing on unformed stool
  • Do not test asymptomatic patients or for “test of cure”
  • Stool culture is most sensitive test
  • Toxigenic culture is the gold standard for CDI testing
  • EIA is suboptimal for diagnostic testing
  • GDH followed by cell cytotoxicity or toxigenic culture is a potential
  • ption for testing (2‐step procedure)
  • rtPCR may be the optimal test‐more data needed
  • Repeat testing is of limited value

SH Cohen et al, ICHE 31:431‐55, 2010

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2014 Silver Award Recipient

Tips on prevention of transmission

Early Recognition Early Precautions Hand Hygiene Environmental Cleaning

2014 Silver Award Recipient

Contact Precautions

Core Supplemental

  • Gloves/gowns on room entry
  • Private room (preferred) or cohort

with dedicated commodes

  • Dedicated equipment
  • Maintain for duration of diarrhea
  • Measure compliance
  • Extend use of Contact

Precautions beyond duration of diarrhea (hospitalization)

  • Presumptive isolation
  • Universal glove use on units

with high CDI rates

  • Intensify assessment of

compliance

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Kansas HEN 2.0 Collaborative Meeting November 18, 2015 13

2014 Silver Award Recipient

Tips on prevention of transmission

2014 Silver Award Recipient

Special Contact Precautions

2014 Silver Award Recipient

CONTACT PLUS Precautions

CONTACT PLUS Signage Yellow Caddy

  • Floor

“STOP” sign decal

  • Filled with

gowns, gloves

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Kansas HEN 2.0 Collaborative Meeting November 18, 2015 14

2014 Silver Award Recipient

Safe Zone

2014 Silver Award Recipient

Tips on prevention of transmission

Early Recognition Early Precautions Hand Hygiene Environmental Cleaning

2014 Silver Award Recipient

Hand Hygiene

Core

  • Hand hygiene based on CDC
  • r WHO guidelines
  • Soap and water preferentially

in outbreak or hyper endemic settings

  • Measure compliance

Supplemental

  • Soap and water for hand

hygiene before exiting room

  • f a patient with CDI
  • Intensify assessment of

compliance

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2014 Silver Award Recipient 2014 Silver Award Recipient

25%

2014 Silver Award Recipient

This or That?

A B

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Kansas HEN 2.0 Collaborative Meeting November 18, 2015 16

2014 Silver Award Recipient

This or That?

A B

2014 Silver Award Recipient 2014 Silver Award Recipient

Hand hygiene – Happy Birthday??

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Kansas HEN 2.0 Collaborative Meeting November 18, 2015 17

2014 Silver Award Recipient 2014 Silver Award Recipient

Tips on prevention of transmission

Early Recognition Early Precautions Hand Hygiene Environmental Cleaning

2014 Silver Award Recipient

Environmental Cleaning

Core Supplemental

  • Cleaning and disinfection of

equipment and environment

  • Consider sodium hypochlorite

in outbreak or hyper endemic settings

  • Routinely assess adherence to

protocols and adequacy of cleaning

  • Reassess adequacy of

room cleaning and address issues

  • Use sodium hypochlorite

(bleach) – containing agents

www.cdc.gov/ncidod/dhqp/id_CdiffFAQ_HCP.html Dubberke et al. Infect Control Hosp Epidemiol 2008;29:S81‐92 Cohen et al. Infect Control Hosp Epidemiol 2010;31

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2014 Silver Award Recipient

High Touch Objects: What Are They?

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  • “Where the germs are”
  • Sites most frequently contaminated and touched by patients

and healthcare workers

  • Germs get spread around by people touching these

places

– Patients get infections from these germs

2014 Silver Award Recipient

Tools for Success

  • WakeMed Infection Prevention team

– HTO closet sign, HTO cart sign – Room marking gel, room audit checklist, black light – Saving Lives Club certificate, pin, candy

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Kansas HEN 2.0 Collaborative Meeting November 18, 2015 19

2014 Silver Award Recipient

Audit Process

  • Done by staff not EVS management
  • Non‐punitive
  • Covert
  • Bed tracking and patient transport systems; unit clerks, charge

RNs, primary RNs

  • Target individuals as able
  • Employee schedule, methodical, heat map

2014 Silver Award Recipient

Audit Process

  • Behaviors

– Preserve privacy, respect

  • NERVES

– Stay humble

  • Scripting
  • Bring employee to room to review audit

– Close door, reassure – Shine light, they re‐clean missed HTOs

  • Right chemicals, right steps

– Reinforce contact times, purpose of work

  • “I’ll still love you tomorrow”
  • CANDY!

2014 Silver Award Recipient

Saving Lives: One Room At A Time

  • Reward System

– EVS voted on name – Employee Relations

  • Certificate, pin
  • Name in Microscope

– EVS management

  • Call/email when 100%
  • Monthly list of names by time clock
  • Pictures from pin ceremony by time clock

– Staff

  • Quarterly pin ceremony
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2014 Silver Award Recipient

Major Modifiable Risk Factors

Acquisition of C. difficile Antibiotic Exposure

2014 Silver Award Recipient

30‐50% of antimicrobial use in acute care is either inappropriate or suboptimal

Hecker MT, et al. Arch Intern Med. 2003; 163: 972‐978. Cosgrove, SE, SK Seo, MK Bolon, et al. Infection Control and Hospital Epidemiology , Vol. 33, No. 4, Special Topic Issue: Antimicrobial Stewardship (April 2012), pp. 374‐380.

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Kansas HEN 2.0 Collaborative Meeting November 18, 2015 21

2014 Silver Award Recipient

Do you have an Antibiotic Stewardship Program?

2014 Silver Award Recipient 2014 Silver Award Recipient

Rationale for Antimicrobial Use Optimization

  • Antimicrobial resistance

– Inherent – Antimicrobial exposure

  • Patient safety

– Arrhythmias, rhabdomyolysis, nephrotoxicity, Clostridium difficile infections, death

  • Cost

– Unnecessary use, switching from IV to PO, broad‐spectrum to pathogen‐directed therapy

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Kansas HEN 2.0 Collaborative Meeting November 18, 2015 22

2014 Silver Award Recipient

Antibiotic misuse adversely impacts patients Clostridium difficile

  • Antibiotic exposure is the single most important

risk factor for the development of Clostridium difficile associated disease (CDAD)

  • Up to 85% of patients with CDAD have antibiotic

exposure in the 28 days before infection

Chang HT et al. Infect Control Hosp Epidemiol 2007; 28:926–931.

2014 Silver Award Recipient

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Antimicrobial Stewardship Program (ASP)

Promotes appropriate use of antimicrobials by selecting the appropriate agent, dose, duration and route of administration

2014 Silver Award Recipient

ASPs can impact HO‐CDI

  • Much data to show that antimicrobial use optimization can

improve HO‐CDI rates

  • ASPs can be implemented in the community setting without ID

pharmacists/physicians

  • CDC and American Hospital Association recommend ASP in

every US hospital

– http://www.cdc.gov/vitalsigns/antibiotic‐prescribing‐ practices/index.html

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Kansas HEN 2.0 Collaborative Meeting November 18, 2015 23

2014 Silver Award Recipient

ASP Strategies

Patient Evaluation Choice of Antimicrobial Prescription Ordering Dispensing Antimicrobial

  • Education/Guideline
  • Formulary Restriction

and Pre‐authorization

  • Computer‐assisted

strategies

  • Review and Feedback

2014 Silver Award Recipient

ASP Strategy Selection

  • Facility dependent

– Beds and acuity of care – Dedicated personnel – Funds – Pharmacy support – Electronic systems – Laboratory support

2014 Silver Award Recipient

CDC Publication March 2014

Core Elements:

  • Leadership Commitment
  • Accountability
  • Drug Expertise
  • Action
  • Tracking
  • Reporting
  • Education

http://www.cdc.gov/getsmart/healthcare/implementation/core‐elements.html

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Checklist for Core Element for Hospital ASP

2014 Silver Award Recipient

Checklist for Core Element for Hospital ASP

http://www.cdc.gov/getsmart/healthcare/pdfs/checklist.pdf

2014 Silver Award Recipient

Antibiotic Stewardship

Getting Started (the basics)

  • Review the published literature
  • Survey of local physicians to see what their needs were and how we could

help

  • Pull together multidisciplinary team

– Pharmacy – Lab Manager/Micro Tech – Quality/Risk – Infection Prevention – IP Physician Lead

  • Look at IT Resources
  • Develop goals
  • Start small – target one class/infectious syndrome
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2014 Silver Award Recipient

Set your sites on achievable targets

  • Asymptomatic bacteriuria
  • Cellulitis pathway
  • Indication and expected duration

for each antibiotic

  • Cultures obtained before

antibiotic(s) administered

  • Post‐prescriptive review at 72

hours

  • Formulary restriction
  • IV to PO switch

2014 Silver Award Recipient

  • Focused on appropriate

perioperative antibiotic use

– Distributed Periop Antibiotic card – Presented at meetings with Surgery, Ortho, Anesthesia – “Fall outs” received letter from Quality, detailing by ID MD – CPOE included automated stop dates

Surgeon outreach

2014 Silver Award Recipient

What’s the Poop…mmm...Scoop?!

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2014 Silver Award Recipient

Approaches to Prevent CDI

Gerding D N , Johnson S. CID 2010;51:1306‐1313

2014 Silver Award Recipient

CDI Prevention

How do we stop this?

–Hand Hygiene –Isolation Procedures/Barrier Precautions –Environmental Services – Cleaning Routines –Antibiotic Stewardship –Bowel Flora Restoration

  • Florastor
  • Active Yogurt
  • Fecal Transplant

–Staff Education –Patient/Family Education –Communication

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2014 Silver Award Recipient

Contact Information Cheryl Ruble, RN, MS, CNS Improvement Advisor Cynosure Health cruble@cynosurehealth.org

2014 Silver Award Recipient

CDI & ASP Education/Resources

  • http://www.hret‐hen.org
  • http://www.shea‐
  • nline.org/Portals/0/PDFs/Guidance%20for%20the%20Knowledge%20and

%20Skills%20Required%20for%20Antimicrobial%20Stewardship%20Leader s.pdfhttps://www.coursera.org/course/antimicrobial

  • http://www.shea‐online.org/View/ArticleId/289/Compendium‐of‐

Strategies‐to‐Prevent‐Healthcare‐Associated‐Infections‐in‐Acute‐Care‐ Hospitals‐2014‐Up.aspx

  • http://journals.cambridge.org/action/displayAbstract?fromPage=online&ai

d=9496695&fileId=S0195941700093279

  • http://www.sidp.org/Default.aspx?pageId=1442823
  • http://www.stewardship‐education.org/
  • http://www.shea‐
  • nline.org/PriorityTopics/AntimicrobialStewardship/ImplementationToolsR

esources.aspx