INVESTOR PRESENTATION 2018 IMMUN UNOPR OPRECI ECISE SE - - PowerPoint PPT Presentation

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INVESTOR PRESENTATION 2018 IMMUN UNOPR OPRECI ECISE SE - - PowerPoint PPT Presentation

TSX.V : IPA OTC : IPATF INVESTOR PRESENTATION 2018 IMMUN UNOPR OPRECI ECISE SE ANTIBODIES BODIES, , LTD. UNIT 3204-4464 MARKHAM STREET VICTORIA, BRITISH COLUMBIA V8Z 7X8, CANADA IMMUN UNOPR OPRECI ECISE.CO SE.COM


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www.immunoprecise.com TSX.V : IPA OTC : IPATF IMMUN UNOPR OPRECI ECISE SE ANTIBODIES BODIES, , LTD. UNIT 3204-4464 MARKHAM STREET VICTORIA, BRITISH COLUMBIA V8Z 7X8, CANADA IMMUN UNOPR OPRECI ECISE.CO SE.COM

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INVESTOR PRESENTATION 2018

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Dis isclosures

  • sures

www.immunoprecise.com

DISCLAIMER This presentation is not, and nothing in it should be construed as, an offer, invitation or recommendation in respect of ImmunoPrecise Antibodies Ltd. (the “Company”) securities, or an offer, invitation or recommendation to sell, or solicitation of an offer to buy, the facilities or of the Company’s securities in any jurisdiction. Neither this presentation nor anything in it shall form the basis of any contract or commitment. This presentation is not intended to be relied upon as advice to investors or potential investors and does not take into account the investment objectives, financial situation or needs of any investor. All investors should consider such factors in consultation with a professional advisor of their choosing when deciding if an investment is appropriate. The Company has prepared this presentation based on information available to it, including information derived from public sources that have not been independently verified. No representation or warranty, express or implied, is provided in relation to the fairness, accuracy, correctness, completeness or reliability of the information,

  • pinions or conclusions expressed herein. These projections should not be considered a representation of the Company’s potential cash generation performance in any way.

FORWARD LOOKING STATEMENTS This presentation includes forward-looking statements, including future-oriented financial information (“FOFI”). Forward-looking statements can generally be identified by the use of language such as “may”, “expect”, “estimate”, “anticipate”, “intend”, “believe”, “potential” and “continue” or the negative thereof or similar variations. Forward-looking statements are not statements of historical fact or assurances of future performance. They are based on the current beliefs, expectations and assumptions of the Company’s management about the Company’s business, planned acquisitions, future plans, anticipated events and other future conditions. All forward–looking statements attributable to the Company or persons acting on its behalf apply only as of the date of this document, and are expressly qualified in their entirety by the cautionary statements included in this

  • presentation. The Company undertakes no obligation to update or revise these forward–looking statements to reflect events or circumstances that arise after the date made or to reflect the occurrence of unanticipated
  • events. Inevitably, some assumptions will not materialize, and anticipated events and circumstances may affect the ultimate financial results. Projections are inherently subject to substantial and numerous uncertainties

and to a wide variety of significant business, economic and competitive risks, and the assumptions underlying the projections may be inaccurate in any material respect, including, but not limited to, those risks set forth in the Company’s Management Discussion and Analysis for the interim period ended October 31, 2017, a copy of which may be obtained from SEDAR.com. In addition, the forward-looking statements, including FOFI, contained in this presentation assume that the Company’s proposed acquisitions of ModiQuest Research BV (“ModiQuest”) and Preclinics Gesellshaft fuer praeklinische Forschung mbH (“Preclinics”) are completed as planned. The Company has not yet entered into definitive agreements for these acquisitions and there are no assurances that they will complete as planned or on the terms previously announced by the Company. Therefore, the actual results achieved may vary significantly from the forecasts, and the variations may be material. The purpose of FOFI provided in this presentation is to provide prospective investors with information pertaining to the Company’s long term business objectives. Readers are cautioned that this information may not be appropriate for other purposes.

TSX.V : IPA OTC : IPATF

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Ab Abou

  • ut

t Im Immun unoPrecis

  • Precise

www.immunoprecise.com TSX.V : IPA OTC : IPATF

Who we are: e:

  • An integrated antibody solutions company which serves as a single source provider of services across

the full antibody discovery value chain (antigen design, hit generation, lead selection, lead optimization and lead characterization). Our Focus cus: :

  • Full spectrum of antibody production methodologies; library-based technologies, hybridoma methods,

transgenic animal-based platforms and single B cell-based technology

  • Growing focus on generating therapeutic, human antibodies

Growth: wth:

  • IPA has unique capabilities in the antibody discovery space, and is focused on strategic growth in next

generation of human, therapeutic antibody discovery - from target identification through pre-clinicals.

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Man anagemen agement t an and d Bo Boar ard d of

  • f Dir

irect ectors

  • rs

www.immunoprecise.com Dr. . Jenn nnifer ifer Bath PRESIDENT SIDENT AND CHIEF F EXECUTIVE UTIVE OFFICER CER James mes Kuo,

  • , MD, MBA

CHAIRMA RMAN Robert bert Beecr croft

  • ft

CHIEF F TECHN HNICA CAL OFFICER ER AND DIRECT ECTOR OR Dr. . Robert bert Burke rke DIRECT ECTOR OR Greg eg Smith th DIRECT ECTOR OR AND AUDIT DIT COMMI MITTE TTEE E CHAIR Guy Champa ampagn gne DIRECT ECTOR OR Dr. . Deanna eanna Dryhur yhurst st CHIEF F SCIENTIFIC NTIFIC OFFICER CER Reg Beniac niac, , MBA, , CPA CHIEF F COMME MERCIAL RCIAL OFFICER ER Na Natasha tasha Tsai ai, CPA, , CA CHIEF F FINANCIAL NCIAL OFFICER CER Teri ri Otto VP , MARKETIN KETING G AND SALES S SUPPORT ORT Dr. . Kevin vin Wong ng VP VP , CORPORA ORATE E SERVICES VICES TSX.V : IPA OTC : IPATF

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Founded in 1989, ImmunoPrecise Antibodies, Ltd. (IPA) has focused on delivering the highest standard of excellence in the antibody discovery process while serving clinical research and biological markets worldwide. Since that time, IPA has expanded significantly, with multiple laboratories in Victoria, Canada and Utrecht & Oss, Netherlands. Robert Beecroft, Founder, Chief Technical Officer and Director is an innovator who helped developed key methodologies that have set IPA apart from other antibody companies:

  • 1. Rapid Prime immunization strategy in mice and rats
  • 2. Expansive, therapeutically-relevant immunization approaches
  • 3. Single-Step Cloning for HAT selection of hybridomas
  • 4. Recombinant monoclonal antibody technology for the generation of Rabbit Monoclonal Antibodies

Qua uali lity ty an and d In Inno novation vation

www.immunoprecise.com TSX.V : IPA OTC : IPATF

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Our Visi sion:

  • n:

To be the industry’s ‘partner of choice’ for the development of therapeutics for major diseases (immuno-oncology, inflammatory, neurodegenerative and autoimmune) www.immunoprecise.com

ImmunoPrecise’s Vi Visio ion n

TSX.V : IPA OTC : IPATF

Accompl

  • mplis

ished hed by:

Offering the most comprehensive collection of antibody discovery platforms combined with state of the art lead candidate

  • ptimization and characterization. This allows us to assist clients from the moment they identify a therapeutic target to the time

they are preparing to apply for investigation review of the clinical product.

The Market: ket:

Therapeutic monoclonal antibody CRO’s are growing three time faster than any CRO in an any CRO space

IPA is poised to become the premier single-source service provider for the therapeutic antibody discovery industry

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www.immunoprecise.com TSX.V : IPA OTC : IPATF

No single antibody discovery platform can be representative of the full repertoire of antibodies present in-vivo

The he Pr Prob

  • blem

lem

Therape rapeutic utic Antibo ibody dy Dis iscovery covery can be a long g proces cess s wit ith h uncert ertai ain n outcomes comes

  • Traditional hybridoma, recombinant single B-cell and library technologies should be used in a complimentary fashion
  • Pharma companies are required to use a number of CRO’s to complete the value chain:

➢ Antibody Discovery ➢ Candidate Characterization ➢ Optimization / Humanization ➢ Antibody Production

Conc nclusion lusion:

  • Process can be laborious, time-consuming, and unreliable
  • Multiple discovery platforms should be used to ensure greatest chance of success
  • Pharma and biotech have been actively demanding more services under one roof

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www.immunoprecise.com

The he Gap ap in in th the e Mar arket ket

TSX.V : IPA OTC : IPATF

Pharma arma rely ly heavily ily on CR CROs for antibo ibody dy disc scov

  • very

ery

  • Lowers their cost
  • Faster turn around time
  • Access to advanced, integrated expertise

A p pione

  • neeri

ering ng CR CRO should uld:

  • Produce fully human antibodies
  • Use immunization technologies that optimize chances of a clinical therapeutic
  • Move beyond traditional hybridoma technology
  • Guide candidate selection through powerful, high-throughput antibody characterization, to select antibodies with most

promise for clinic

Due to the rapid advancement of technology and a lack of qualified personnel, many biopharmaceutical companies find it difficult to undertake all drug discovery operations in-house

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www.immunoprecise.com

IPA A offers fers a c complete mplete portfolio tfolio of antibody ibody discov covery ery, , charact racteri erization zation and productio duction n technol hnologi

  • gies

es

  • Human Antibodies

➢ Recently designated a preferred CRO for the leading, global transgenic animal platform ➢ Offer humanization of animal-derived antibodies

  • Multiple immunization methods optimized for therapeutic targets
  • Full spectrum of antibody production methodologies

➢ library-based technologies, hybridoma methods, single B cell-based technology ➢ New techniques offer a ‘deeper’ selection of antibodies with a greater repertoire of therapeutic properties

  • High-throughput antibody characterization

TSX.V : IPA OTC : IPATF

The he Sol

  • lut

ution ion

IPA possess next generation technologies and the expertise required to assist in the development of novel antibody-based therapies

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www.immunoprecise.com TSX.V : IPA OTC : IPATF

US US an and Ca d Cana nada da An Anti tibo body dy Cl Clini nica cals ls 20 2013 13-2017 2017

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clinicaltrials.gov

The he Suc uccess cess of

  • f An

Antib ibodies

  • dies

TSX.V : IPA OTC : IPATF www.immunoprecise.com

Transge sgeni nic c animal als s are provi ving ng to be more effective ctive for the producti uction

  • n of therape

apeut utics cs

  • There are two competing technologies for therapeutic antibody discovery
  • Transgenic animals
  • Display technology
  • Of the 28 FDA approved human antibodies
  • 21 generated with transgenic animals
  • 6 using display technology

The number of antibody-based therapeutics in clinical trials has grown from 150 in 2008 to over 500 in 2017

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www.immunoprecise.com

  • Antibo

bodi dies es as drugs

  • Nine of the top-selling fifteen drugs in 2022 are predicted to be monoclonal antibodies
  • Therap

apeutic eutic market et

  • $50 billion in 2011
  • Estimated at $150 billion in 2020
  • Incre

reasi asing ng financia ial l health th of pharmace aceut utica cal l compani nies es

  • Profitable growth due to increasing R&D efforts in the therapeutics industrya
  • Growing emphasis on antibody development at CROs

TSX.V : IPA OTC : IPATF

An Antib ibodies

  • dies an

and d the he Mar arket ket

Monoclonal antibodies have emerged as a major class of therapeutics for immunological infectious diseases and cancer

aGrand View Research, Inc. 11

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www.immunoprecise.com

The he Gol

  • lden

den Ag Age o e of Mon

  • noc
  • clonal
  • nal An

Antib ibodies

  • dies
  • Record

rd year in 20 2017

  • FDA and EMA approved ten monoclonal antibody drugs globallyb
  • Total number has reached 73 (as of Dec. 31st, 2017)
  • The key players serving the Monoclonal Antibodies Market are:

12 bThe Antibody Society

TSX.V : IPA OTC : IPATF

Pfizer Inc. GlaxoSmithKline plc. Novartis AG. Merck & Co Inc. Amgen Inc. Abbott Laboratories AstraZeneca Eli Lilly and Company Mylan N.V. Daiichi Sankyo Company Ltd. Bayer AG, Bristol Myers Squibb Co. Johnson & Johnson Services Inc. Biogen Inc. Thermo Fisher Scientific Inc. Sanofi Genzyme F . Hoffmann-La Roche Ltd. Novo Nordisk A/S.

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ImmunoPrecise provides state-of-the-art therapeutic antibody discovery across the entire discovery and validation pipeline.

  • IPA will become an industry leading CRO by providing:

✓ Advanced therapeutic immunization strategies in transgenic animals ✓ Accelerated B-Cell screening ✓ Multiple antibody discovery platforms ✓ Guidance in lead candidate selection ✓ In vitro and in vivo characterization ✓ Strategic investments

  • This will result in high throughput and deep output comprehensive antibody discovery program to enhance the

discovery of therapeutically-relevant antibodies

www.immunoprecise.com

In In Su Summary ary

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TSX.V : IPA OTC : IPATF

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Ma Mail iling ing Addre dress: s: ImmunoPr unoPrecise cise Antibod ibodies, ies, Ltd. Vancouver Island Technology Park Unit 3204-4464 Markham Street Victoria, British Columbia, V8Z 7X8, Canada ImmunoPrecise Antibodies, Ltd. Jennifer nnifer L. Bath, th, Ph.D. Telephone: +1-778-966-1252 E-mail: jennifer@immunoprecise.com Contact Financial Frédér édéric ick k Chabot abot Telephone: +1-438-863-7071 Email: frederick@contactfinancial.com

Co Contact act In Inform

  • rmation

ation

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www.immunoprecise.com