SLIDE 4 2/27/2017 4
“WERE YOU EXPOSED TO ANY CHEMICALS?”
- ~1 hour prior to onset of symptoms, she sprayed her shoes
with a waterproofing spray. She used it indoors with the windows closed and without PPE. She had used it similarly in the past without any apparent adverse effects.
“HILL WALKERS LUNG”
- Acute alveolitis or interstitial pneumonitis after acute inhalation of water
repellant sprays; distinct from polymer fume fever.
- Contents of the sprays: Propellants (propane, butane, isooctane) and water
repellant (fluorocarbons, silicone resins)
- Dyspnea, dry cough and an acute febrile and flu-like disease
- Disrupts alveolar surface tension and surfactant -- alveolar collapse? In
animals causes necrosis of alveolar cells, alveolar hemorrhage and edema.
Epping et al. Int J Occup Med Environ Health. 2011, 24(4):409-13
OTHER HEALTH EFFECTS OF PFOA AND PFOS
- In humans:
- Immune alterations, low birth weight, decreased head circumference, reduced birth
length, and smaller abdominal circumference
- Associations with testicular and kidney cancer.
- In animals:
- Developmental toxicity, changes in brain function and behavior, altered mammary gland
development, immune system effects, altered weight gain after in-utero exposure, thyroid hormone disruption, and reduced testosterone.
- Increased incidence of tumors of the liver, testes, and pancreas.
Grandjean et al. Environmental Health 2013, 12:35. http://biomonitoring.ca.gov/chemicals/perfluorochemicals-pfcs
PRESERVATIVES: MCI AND MI
- Methylchloroisothiazolinone (MCI) and methylisothiazolinone (MI)
- Introduced for industrial use in 1980
- Approved by the FDA in 2005 (max conc. 100 ppm)
- Now in >1000 products: baby lotions, bath products, makeup,
hair care products, deodorants, skin care products, sunscreens
- First case reports of sensitization in 2011
