Weight (BMI) the apple doesnt fall far from the tree Obesity and - PowerPoint PPT Presentation

Odds Ratio of Knee OA with Obesity for Women Klussmann et al., Arthritis Res Therapy, 2010 Odds Ratio Weight (BMI)

the apple doesn’t fall far from the tree

Obesity and Disease Pathways Obesity Decreased Increased Increased Cytokine Activity Muscle Function Joint Loads Decreased strength, power, proprioception Subchondral Tissue Damage Cartilage Loss, Synovitis PAIN Loss of Mobility Disability

Compressive Compressive For every 1 lb 4 lb decrease in knee compressive forces weight loss Weight Loss per step Tibia Messier, Gutekunst, Davis, DeVita, Arthritis Rheum, 2005

Bonnet, Walsh, Rheumatology, 2005;44:7-16.

C-reactive protein Diet Control Exercise Exercise + Diet .2 Change in log(CRP) 0 -.2 -.4 0 6 18 Month Nicklas et al., 2004

ADAPT Survivorship 8 years later 1.0 Survivorship function Weight-loss 0.9 Non-weight-loss 0.8 Shea et al. J Gerontol: Med Sci. 2010;65A:519-525 0.7 0 1000 2000 3000 4000 Days *Adjusted for age, gender, exercise treatment