SLIDE 1
Odds Ratio
Weight (BMI)
Odds Ratio of Knee OA with Obesity for Women
Klussmann et al., Arthritis Res Therapy, 2010
Weight (BMI) the apple doesnt fall far from the tree Obesity and - - PowerPoint PPT Presentation
Weight (BMI) the apple doesnt fall far from the tree Obesity and - - PowerPoint PPT Presentation
Odds Ratio of Knee OA with Obesity for Women Klussmann et al., Arthritis Res Therapy, 2010 Odds Ratio Weight (BMI) the apple doesnt fall far from the tree Obesity and Disease Pathways Obesity Decreased Increased Increased Cytokine
SLIDE 2
SLIDE 3
Increased Joint Loads
Subchondral Tissue Damage Cartilage Loss, Synovitis
PAIN
Decreased strength, power, proprioception
Loss of Mobility
Disability
Increased Cytokine Activity
Obesity
Decreased Muscle Function
Obesity and Disease Pathways
SLIDE 4
Weight Loss
Compressive
Messier, Gutekunst, Davis, DeVita, Arthritis Rheum, 2005 Tibia
Compressive
For every 1 lb weight loss
4 lb decrease in knee compressive forces per step
SLIDE 5
Bonnet, Walsh, Rheumatology, 2005;44:7-16.
SLIDE 6
Change in log(CRP) Month
Control
Diet
Exercise + Diet
Exercise
6 18
- .4
- .2
.2
C-reactive protein
Nicklas et al., 2004
SLIDE 7
Shea et al. J Gerontol: Med Sci. 2010;65A:519-525
Weight-loss Non-weight-loss
Survivorship function
0 1000 2000 3000 4000 Days
1.0 0.9 0.8 0.7
*Adjusted for age, gender, exercise treatment