Understanding NIH: Drinking from the Fire-hose Rosemarie Hunziker, - - PowerPoint PPT Presentation
Understanding NIH: Drinking from the Fire-hose Rosemarie Hunziker, PhD Tissue Engineering/Regenerative Medicine and Biomaterials Program Director National Institute of Biomedical Imaging and Bioengineering (NIBIB) National Institutes of
Rosemarie Hunziker, PhD
Tissue Engineering/Regenerative Medicine and Biomaterials Program Director National Institute of Biomedical Imaging and Bioengineering (NIBIB) National Institutes of Health (NIH) hunzikerr@mail.nih.gov 301-451-1609
− NIH − NIBIB
− Each IC has a unique character − Get help from the inside
− Organize your team and plan − Specific Aims are the bedrock − Make reviewers your advocates
− NIH
Source: http://www.nih.gov/about/director/budgetrequest/fy2016_directorsbudgetrequest_slides.pdf
− BRAIN Initiative − Microbiome and health − Stem Cell Technology (tissue chips, regenerative medicine) − New Vaccines (Ebola, Flu, HIV…)
− Antimicrobial Resistance
− Alzheimer’s Disease
− Accelerating Medicine Partnership (Alzheimer’s, type 2 diabetes, lupus, rheumatoid arthritis)
workforce
http://www.nih.gov/precisionmedicine/
The human brain has 1011 neurons, each connected to 104 other neurons. Sitting on your shoulders is the most complicated object in the known universe. http://braininitiative.nih.gov/
showing individual cells and complex circuits
resolution tools
through targeted initiatives (basic neuroscience, classification of
circuits, recording and modulating—non-invasively)
Stimulating Peripheral Activity to Relieve Conditions (SPARC)
First Call:
RFA-RM-15-002: Exploratory Technologies to Understand the Control of Organ Function by the Peripheral Nervous System for SPARC (U18)
12 awards
airway, gastrointestinal tract
function for effective, minimally invasive neuromodulation therapy
http://commonfund.nih.gov/
Health Economics Single Cell Analysis Gulf Oil Spill Human Microbiome Protein Capture
Early Independence New innovators Pioneers Transformative R01s
Bioinformatics and Computational Biology Genotype- Tissue Expression Library of Integrated Network- Based Cellular Signatures (LINCS) Science of Behavior Change Global Health HCS Research Collaboratory Epigenomics 4D Nucleome Gabrielle Miller Kids First Illuminating the Drugable Genome Molecular Transducers of Physical Activity Stimulating Peripheral Activity to Relieve Conditions (SPARC) Biomedical Workforce NIH Workforce Diversity Big Data to Knowledge Metabolomics Undiagnosed Diseases
Common Fund
Transformative – Catalytic Synergistic – Unique Cross-cutting
Glycoscience Regulatory Science Nanomedicine Knockout Mouse Phenotyping High-risk Research
= watch for new initiatives
NIBIB
(46 = 4.2%)
NIDCR
(35 = 3.5%)
NIAMS
(33 = 1.7%)
NHLBI
(65 = 1.2%)
NIDDK
(32 = 1.1%)
NINDS
(23 = 0.7%)
NEI
(11 = 0.7%)
NHGRI
(1 = 0.5%)
(by percent of total investment, FY14) Total Awards
< 0.5% = NIDCD(4), NIGMS(21), NCI(32), OD(1), NIEHS(3), NCATS(3), NIMH(11), NIAID(11), NIA(5), NICHD(3), FIC(1), NIAAA(0), NIDA(0), NLM(0), NIMHD(0), NINR(0), NCCAM(0)
NIH average 0.5%
** *** **** ** * * = > 2% (NIH average) in
Regenerative Medicine
* = 341
integrating the physical and engineering sciences with the life sciences to advance basic research and medical care support research into the causes, treatment, and prevention of arthritis and musculoskeletal and skin diseases, training of basic and clinical scientists for this improve oral, dental and craniofacial health through research, training, and dissemination of health information
NHLBI NIDDK NIBIB NIDCR NIAMS
medical research, training and dissemination of science- based information on diabetes and other endocrine and metabolic diseases; digestive diseases, nutritional disorders, and obesity; and kidney, urologic, and hematologic diseases global leadership for a research, training, and education program to promote the prevention and treatment of heart, lung, and blood diseases
− NIBIB
There are two kinds of scientific revolutions, those driven by new tools and those driven by new concepts… The effect of a concept- driven revolution is to explain old things in new ways. The effect
be explained.
It’s not enough to be UNIQUE… you must also be USEFUL.
Featured Mechanisms
Featured Programs
Monitoring Systems (PRISMS)
and Biologics
Display
Devices
Devices
Spectroscopy
Analysis
Scientific Program Areas
Creating Biomedical Technologies to Improve Health
Research Grants (EBRG) (R21) early and conceptual stages of new exploratory and developmental research that may involve considerable risk but may lead to a breakthrough
integrated, systems approach to basic and applied multi- disciplinary research that addresses important biological, clinical or biomedical research problems
(R01) team approach to basic, applied, and translational multi- disciplinary research to establish a robust engineering solution to a biomedical problem
BioTechnology Resource Centers (P41)
− national/international impact − innovative, cutting-edge − complex, multidisciplinary − high-risk test beds leading to practical tools
− dynamic, push-pull relationships
− geographically diverse − technology push − exploit more mature capabilities of the Center
– research papers, reviews – patents – presentations, workshops – website(s)
– senior scientist to “herd cats” – experienced TR&D Leaders – Scientific Advisory Board – institutional Support
TR&D project TR&D project TR&D project CP SP A D M I N I S T R A T I O N CP CP CP CP CP CP CP SP SP SP SP SP
P41 Components & Structure
(PAR-15-031)
Current projects:
(U01) − environmental exposures − physiological signals − activity − behavior in a natural environment
platforms (U24) − processing − visualization − secure uploading
to empower epidemiological studies
Thanks to Peter Hunter
Genes, mRNA Cell Tissue Organism Organ Proteins, Lipids, Carbohydrates Population
30,000+ genes 100,000+ proteins 12 organ systems 1 body 200+ cell types 4 tissue types 102 - 106 people
IMAG Funding Opportunity - PAR 15-085:
Predictive Multiscale Models for Biomedical, Biological, Behavioral, Environmental and Clinical Research (U01)
the box
ONR
funded efforts to the MSM Consortium
Interagency Modeling and Analysis Group
− Each IC has a unique character − Get help from the inside
Research Development
Spectrum of support
Entrepreneurial Experienced
PI/Team Qualifications
High Risk High Feasibility
Probability of success NSF NIH DARPA
basic applied
NIH Divides most of its investment according to the interests of the component parts (i.e. Institutes or Centers), with <4% allocated to trans-NIH initiatives. About 85% distributed via Extramural grants, contracts, cooperative agreements
Total = $30.4 B
NCI NIAID NHLBI
NIGMS NIDDK NINDS NIMH OD NICHD NIA NIDA
NIEHS NEI NIAMS NHGRI NCATS NIDCR NIAAA NIDCD NIBIB NLM NIMHD NINR
NCCAM FIC
accelerating the application of biomedical technologies… [via] integrating the physical and engineering sciences with the life sciences to advance basic research and medical care.
NIBIB mission NINDS mission
seek fundamental knowledge about the brain and nervous system and to use that knowledge to reduce the burden of neurological disease. Novel polymer scaffold for tissue regeneration Pivotal large animal studies for stroke therapy Neural progenitor cells in biomimetic matrix in rat brain
Imaging cells transplanted to the brain
Neural differentiation
Need Help with Your Proposal… Who Ya’ Gonna’ Call?
about the scientific and technical aspects of your application… Program Director for questions during the review… Scientific Review Officer for help with the business aspects of a proposal… Grants Specialist
(http://www.nih.gov/icd/index.html).
submitted proposal
CSR web site
submitted proposal
(http://www.nih.gov/icd/index.html).
contact
Pre-Application
your ideas together
Application Award Review Post Review
deeper insights from the Review
likelihood of funding
have it in writing
During the Award
(rebudgeting, re-scoping, extensions…)
unusual issues
Anytime
serve on advisory boards, workshop panels, etc.
Soon in Funding Opportunities
http://report.nih.gov/quicklinks.aspx
Search by
https://loop.nigms.nih.gov/index.php/2012/12/03/how-to-use- reporter-when-preparing-new-grant-applications/
http://grants.nih.gov/grants/oer.htm
Grant Basics Funding Initiatives Due Dates, Templates
− Organize your team and plan − Specific Aims are the bedrock − Make reviewers your advocates
Planning Meeting Output: Blueprint for Successful Research
Project Title: really a quick summary Principal Investigator(s) and Key Personnel: defines role, commitment Overall goal: resolve an important issue in a timely manner Specific goal: best stated as a hypothesis (a boastful claim, substantiated by data) Impact: 2-3 sentences, define success, distill innovation and significance RESEARCH Responsibilities, Costs, Milestones and Timeline
Overseer Cost Q1 Q2 Q3 Q4 Q5 Q6 Q7 Q8
2a. 2b. 2c.
* * High-risk element. Propose and discuss alternatives. Decision point.
(Transition to next grant.)
SPECIFIC AIMS Page: Formula for Success
innovative solution. Describe the big picture quantitatively. How can
science/engineering help?
target and hypothesis? How will you get there? How do you know?
bold face. Then, identify strategies, methods, assays to be used, and data expected.
Why is this the right group at the right place and time? Outline your specific skill sets.
How will paradigms shift or treatment change, and what will this project contribute?
Significance – Innovation – Investigator(s) – Approach – Environment
Tell your story in five compelling, concise, plain-language paragraphs!
"Simple can be harder than complex. You have to work hard to get your thinking clean to make it simple. But it's worth it in the end, because once you get there, you can move mountains."
“Everything should be made as simple le as possib ible, le, but not simpler.”
− engineers beware: lead with an urgent issue, NOT your cool tools/technologies − discovery (basic) science plus technology development (non-hypothesis driven)
− feasibility = most relevant preliminary data + sound, logical pathway − defend assertions with publications (citing reviewers a plus) − inspiration << invention = innovation − short term objectives inform long term goals − milestones > bold, general ideas − experience, expertise count
− limit jargon/acronyms − reinforce (don’t repeat) important ideas − use legible/sensible figures − strategically place an overview as “eye candy” − proofread!
If you want something in your life you’ve never had, you’ll have to do something you’ve never done.
Guide (http://grants.nih.gov/grants/guide/)
your scientific area and discuss your ideas
− Fit with institute mission and priorities − Best grant mechanism or program − Best study section for review
− Get fresh ideas and directions for your research − Become known to your peers (i.e. reviewers)
(serve on study sections)
Lots of directions and opportunities at the NIH
Step #1: Do your homework; learn a bit about the grant process and the
Step #2: Contact us because… We’re from the Government, we’re here to help you!
Office of Extramural Research: Basics - http://grants.nih.gov/grants/grant_basics.htm Overview - http://grants.nih.gov/grants/grants_process.htm IC priorities: http://www.nih.gov/icd/index.html NIH Guide Provides Weekly Updates on Funding Opportunities: http://grants.nih.gov/grants/guide/ NIH RePORTer – lots of statistics and abstracts of funded grants http://report.nih.gov/
Do science because you can’t imagine doing anything else, and enjoy the ride. No one said it would be easy, only wild.
Rosemarie Hunziker, PhD
Program Director Tissue Engineering/Regenerative Medicine Biomaterials National Institute of Biomedical Imaging and Bioengineering (NIBIB) National Institutes of Health (NIH) 301-451-1609 Rosemarie.Hunziker@nih.gov www.nibib.nih.gov
Creating Biomedical Technologies to Improve Health