SLIDE 6 O B J E C T I V E S M A R K E T
Industrial users needs, expectations and volumes Applications in segments and consumption trends Consumer market trends by food segments Prospective and forecast
M A N U F A T U R E R S
Processes and capacities Market share Company description
R E S E A R C H
New researches and developments New applications FUNCTIONALITIES
THE WORLD LACTOFERRIN AND LACTOPEROXIDASE MARKET
In many ways, lactoferrin has been an easy protein to investigate; however, there have been difficulties understanding specific structure/function relationships, particularly as it functions in vivo; Heat stability: At low ionic strength and/or low pH, the resistance
lactoferrin to heat denaturation is good and methods for heats treatment and pasteurization have been published. Iron bioavailability: Two features
the functional properties of lactoferrin are its ability to bind iron exceptionally tightly and the coupling
- f rigid-body domain movements to iron bindings
and release. Anticarcinogenic effect: Lactoferrin has been reported to inhibit cancer growth by inducing apoptosis and stimulating the production
critical cytokines, such as IL-18 etc. Antimicrobial agent: Its capacity to bind iron and to stay bound with iron until pH 3 interfer in the proliferation of pathogen bacteria. Antiviral agent: Recently, Antiviral activity has been described as well for herpes, cytomegalo and influenzes virus. Inflammatory and Immune response: Lactoferrin has various effects on the immune system, such as regulation
antibody production, complement activation, and natural killer cell function. Anti-oxidant effect: Lactoferrin scavenges excess iron thereby protects the host to peroxidation reactions.
can be combined to lactoferrin in protection of the mucosal surface and prevention of tooth decays. Lactoperoxidase could elicit with bacteriostatic and/or bactericidal activity
a variety
susceptible microorganisms including bacteria, fungi and viruses. The molecular mechanism (s)
- f such inhibitory effects depend on the type of
electron donor, test media, temperature and pH and could range from
killing to blockage of glycolytic pathways or interference in cytopathic effects; Antibacterial Effect: Gram-negative, catalase- positive
such as pseudomonas, coliforms, salmonellae and shigellae, are not
inhibited by the lactoperoxidase system (LPS) but also, depending
the medium conditions (pH, temperature, incubation time, and cell density) may be killed. Gram-positive, catalase negative bacteria, such as streptococci and lactobacilli are generally inhibited but not killed by the LPS. Antifungal Effect: Seifu et al. declared that LPS in goat milk inhibit growth and proliferation of many fungal species viz., Aspergillus flavus, Penicillium chrysogenum, Trichoderma spp., Alternaria spp. and Claviceps spp., Corynespora cassicola, Phytophthora meadii and Corticium salmonicolor; however, Candida albicans and Pythium spp. were not affected by the this system. Antiviral Effect: Shin et al. reported the potential
administration
LPS to attenuate pneumonia in influenza-virus-infected mice through the suppression of infiltration of inflammatory cells in the lung.
