Towards Best Practice for Chronic HIV Care Professor Georg Behrens - - PowerPoint PPT Presentation

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Towards Best Practice for Chronic HIV Care Professor Georg Behrens - - PowerPoint PPT Presentation

Apr 05, 2024 45 likes •165 views

HIV Outcomes: Beyond viral suppression Towards Best Practice for Chronic HIV Care Professor Georg Behrens Department for Clinical Immunology and Rheumatology Hannover University Hospital, Germany HIV infection today From HIV-patients to

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Towards Best Practice for Chronic HIV Care

Professor Georg Behrens Department for Clinical Immunology and Rheumatology Hannover University Hospital, Germany

HIV Outcomes: Beyond viral suppression

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HIV infection today

From HIV-patients to people living with HIV (PLWH)

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57 Age 59

109,000

CD4 HIV-RNA 55 1082

<20

Burkitt lymphoma

AIDS HIV+ HIV+

My patients from last week…

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  • Mindful & dedicated HIV physician
  • Strong & influencial HIV community

Some key steps were driving the success

  • f HIV therapy (we continue to need them)
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  • Mindful & dedicated HIV physicians
  • Strong & influencial HIV community
  • Science, Science, Science
  • Rapidly developing drug pipeline

Some key steps were driving the success

  • f HIV therapy (we continue to need them)
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  • Mindful & dedicated HIV physicians
  • Strong & influencial HIV community
  • Science, Science, Science
  • Rapidly developing drug pipeline
  • Combination therapy (cART)
  • Individualized therapy (e.g. HLA-B 57:01 Testing)

Some key steps were driving the success

  • f HIV therapy (we continue to need them)
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  • Mindful & dedicated HIV physicians
  • Strong & influencial HIV community
  • Science, Science, Science
  • Rapidly developing drug pipeline
  • Combination therapy (cART)
  • Individualized therapy (e.g. HLA-B 57:01 Testing)
  • Novel technologies (PCR in routine lab)
  • Interdisciplinary work (e.g. resistance testing)

Some key steps were driving the success

  • f HIV therapy (we continue to need them)
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  • Mindful & dedicated HIV physicians
  • Strong & influencial HIV community
  • Science, Science, Science
  • Rapidly developing drug pipeline
  • Combination therapy (cART)
  • Individualized therapy (e.g. HLA-B 57:01 Testing)
  • Novel technologies (PCR in routine lab)
  • Interdisciplinary work (e.g. resistance testing)
  • High quality trials (based on surrogate markers)
  • Successful international cohort studies (Networks)
  • …

Some key steps were driving the success

  • f HIV therapy (we continue to need them)
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1st line therapy for HIV patients

Focus on

  • Prevent disease progression
  • Suppress viral replication
  • Prevent resistance mutation development
  • Maintain adherence

Early phase

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Life long therapy for HIV patients

Focus on

  • Long-term toxicity
  • Long-term HIV infection
  • Co-morbidities
  • Ageing

Later phase

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Later phase

25 420

(42%)

<20

HIV+ since birth CD4 HIV-RNA

ART: 2 pills/day!

Life long therapy for HIV patients

Focus on

  • Long-term toxicity
  • Long-term HIV infection
  • Co-morbidities
  • Ageing
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From todays HIV therapy… … to tomorrows HIV medicine! HIV Infection 2.0