Towards Best Practice for Chronic HIV Care Professor Georg Behrens - PowerPoint PPT Presentation

HIV Outcomes: Beyond viral suppression Towards Best Practice for Chronic HIV Care Professor Georg Behrens Department for Clinical Immunology and Rheumatology Hannover University Hospital, Germany

HIV infection today From HIV-patients to people living with HIV (PLWH)

My patients from last week… HIV + HIV + Age 57 55 Burkitt lymphoma CD4 59 1082 HIV-RNA 109,000 <20 AIDS

Some key steps were driving the success of HIV therapy (we continue to need them) • Mindful & dedicated HIV physician • Strong & influencial HIV community

Some key steps were driving the success of HIV therapy (we continue to need them) • Mindful & dedicated HIV physicians • Strong & influencial HIV community • Science, Science, Science • Rapidly developing drug pipeline

Some key steps were driving the success of HIV therapy (we continue to need them) • Mindful & dedicated HIV physicians • Strong & influencial HIV community • Science, Science, Science • Rapidly developing drug pipeline • Combination therapy (cART) • Individualized therapy (e.g. HLA-B 57:01 Testing)

Some key steps were driving the success of HIV therapy (we continue to need them) • Mindful & dedicated HIV physicians • Strong & influencial HIV community • Science, Science, Science • Rapidly developing drug pipeline • Combination therapy (cART) • Individualized therapy (e.g. HLA-B 57:01 Testing) • Novel technologies (PCR in routine lab) • Interdisciplinary work (e.g. resistance testing)

Some key steps were driving the success of HIV therapy (we continue to need them) • Mindful & dedicated HIV physicians • Strong & influencial HIV community • Science, Science, Science • Rapidly developing drug pipeline • Combination therapy (cART) • Individualized therapy (e.g. HLA-B 57:01 Testing) • Novel technologies (PCR in routine lab) • Interdisciplinary work (e.g. resistance testing) • High quality trials (based on surrogate markers) • Successful international cohort studies (Networks) • …

1st line therapy for HIV patients Early phase Focus on • Prevent disease progression • Suppress viral replication • Prevent resistance mutation development • Maintain adherence

Life long therapy for HIV patients Later phase Focus on • Long-term toxicity • Long-term HIV infection • Co-morbidities • Ageing

Life long therapy for HIV patients HIV + since birth Later phase 25 Focus on 420 CD4 • Long-term toxicity (42%) • Long-term HIV infection HIV-RNA • Co-morbidities • Ageing <20 ART: 2 pills/day!

HIV Infection 2.0 From todays HIV therapy … … to tomorrows HIV medicine !