TOTEM Switching the NRTI Backbone to Tenofovir DF-Emtricitabine - - PowerPoint PPT Presentation

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Oct 15, 2023 756 likes •828 views

Switching the NRTI Backbone to Tenofovir DF-Emtricitabine TOTEM Switching the NRTI Backbone to Tenofovir DF-Emtricitabine TOTEM: Study Design Study Design: TOTEM Background : 12-week, multicenter, open-label, randomized trial of

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Switching the NRTI Backbone to Tenofovir DF-Emtricitabine

TOTEM

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Switching the NRTI Backbone to Tenofovir DF-Emtricitabine

TOTEM: Study Design

Source: Valantin MA, et al. J Antimicrob Chemother. 2010;65:556-61.

TDF-FTC + Continue 3rd Agent

(n = 46)

Continue Current ART

(n = 45)

Study Design: TOTEM

Background: 12-week, multicenter, open-label,

randomized trial of substituting the NRTI backbone with TDF-FTC for virologically suppressed patients with elevated lipids

Inclusion Criteria (n = 91)
Adults with HIV infection
HIV RNA <400 copies/mL for >6 months
Elevated fasting LDL or triglycerides
Receiving 2 NRTI’s (not TDF-FTC)

plus an NNRTI or boosted PI

Treatment Arms (Randomized 1:1)
Replace NRTI backbone with TDF-FTC
Continue current regimen

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0.0

0.1
1.25
1.00
0.75
0.50
0.25

0.00 0.25 0.50 Total Cholesterol LDL HDL Triglycerides Change in Mean Value (mmol/L) TDF-FTC + 3rd Agent Continue Current ART

Switching the NRTI Backbone to Tenofovir DF-Emtricitabine

TOTEM: Results

Week 12: Change in Plasma Lipids from Baseline

Source: Valantin MA, et al. J Antimicrob Chemother. 2010;65:556-61. P < 0.001 P = 0.031 P = 0.009 P = 0.034

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Switching the NRTI Backbone to Tenofovir DF-Emtricitabine

TOTEM: Results

Source: Valantin MA, et al. J Antimicrob Chemother. 2010;65:556-61.

Conclusions: “Switching to tenofovir disoproxil fumarate + emtricitabine in dyslipidaemic HIV-infected patients improves triglycerides and LDL- cholesterol.”

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Acknowledgment

The National HIV Curriculum is an AIDS Education and Training Center (AETC) Program resource funded by the United States Health Resources and Services Administration. The project is led by the University of Washington and the AETC National Coordinating Resource Center.

The content in this slide set does not represent the official views of the U.S. Department of Health and Human Services, Health Resources & Services Administration.