The Way Forward Dr David Simpson New therapeutic agents in myeloma - - PowerPoint PPT Presentation

▶

Oct 19, 2022 222 likes •321 views

The Way Forward Dr David Simpson New therapeutic agents in myeloma 2003 2006 2009 2012 2015 2018 Future Bortezomib Thalidomide Lenalidomide Carfilzomib Panobinostat Pharmac Funded Ixazomib Pomalidomide Elotuzumab FDA approved

SLIDE 1

The Way Forward Dr David Simpson

SLIDE 2

Pharmac Funded

2003 2006 2009 2012 2015 2018 Future Bortezomib Carfilzomib Ixazomib Thalidomide Lenalidomide Pomalidomide Panobinostat Elotuzumab Daratumumab Isatuximab Selinexor Anti-BCMA Venetoclax CAR-T

FDA approved In pipeline

New therapeutic agents in myeloma

SLIDE 3

Better outcomes in myeloma

Velcade Thalidomide Cyclophosphamide Dexamethasone Lenalidomide Pharmac What we have Carfilzomib Venetoclax Daratumumab Isatuximab Anti-BCMA Pomalidomide More lenalidomide What we want How do you bridge the gap

SLIDE 4

Curing Myeloma – We need good drugs early

SLIDE 5

Cancer drugs outstrip wages…

SLIDE 6

How much do we spend on drugs?

100 200 300 400 500 600 700 800

USD PPP Annual/Capita Drug Spend

2010 2011 2012 2013 2014 2015 2016 2017

Data extracted on 23 Mar 2019 05:00 UTC (GMT) from OECD.Stat NZ

SLIDE 7

Life-cycle of drug costs

Phase 1 Phase 2 Phase 3

Compassion Access

Brand Drug Generic $0 $100K $100K

Pharmac Research

Years

SLIDE 8

Collect real world data

Pharmac Pharma Global Pricing Unique NHI

SLIDE 9

Solutions

More money for Pharmac Simplify and streamline cancer intervention trials Pharmac to work with Pharma to obtain “real world” data on treatment outcomes to offset new drug costs