The eI4Africa EU/FP7 Project Exploiting e-Infrastructures potential to boost RTDI in Africa info@ei4africa.eu www.ei4africa.eu
African Pharmacological Science Gateway Jaran Eriksen| Karolinska 13/11/2013- 2 Institutet|eI4Africa
Background/Rationale ■ Previous North-South Scientific and Technology transfer drive has not achieved the technology transfer hoped for trained African scientists failing to continue their work upon returning to their home institutions ■ Challenges: ■ brain drain from Africa ■ lack of scientific development ■ A few successful groups set up competence in key research areas important for drug discovery, development and rational use of medicines ■ Remain scientifically isolated with minimal possibilities for South-South interaction to build on the knowledge and technical skills they have individually established ■ Need for strengthened S-S collaboration in this field Jaran Eriksen| Karolinska Institutet|eI4Africa 13/11/2013- 3
African Pharmacological Science Gateway Objectives ■ Design, develop, test, implement and evaluate a concept for cost- effective virtual e-infrastructure collaboration for African medical sciences focusing on the needs of pharmacological sciences and clinical trials for improving African healthcare: ■ Genomics and bioinformatics ■ Pharmacokinetics/pharmacometrics ■ Bioanalysis, drug analysis and metabolism ■ Clinical trial sciences ■ Areas important in drug development and rational use of medicines should be carried out in collaboration across countries ■ All tools and collaborative platforms for this knowledge sharing should be available at the Africa Grid Science Gateway ( http://sgw.africa-grid.org/) as a pharmacological gateway Jaran Eriksen|Karolinska Institutet eI4Africa 13/11/2013 - 4
Strengthening capacity and capability for drug development and rational use of medicines in Africa ■ Ensuring continued laboratory based pharmacological research in Africa by enabling access to tools for analyzing and calculating data, and to expertise in these areas reduce brain drain and unnecessary visits to US/Europe ■ Continued contact, mentorship and access to necessary tools ■ Strong capacity to maintain contacts between African laboratory based pharmacological scientists stimulate establishment of strong clinical pharmacological research in African countries Jaran Eriksen| Karolinska Institutet|eI4Africa 13/11/2013- 5
Properties of shared tools ■ Tools simplifying collaboration across institutions within and outside Africa for basic and clinical drug research ■ The virtual collaborative community should build on easily accessible tools that interested partners can gain access to ■ Open access tools and solutions ■ Establishment of technical competence for maintenance and development Jaran Eriksen| Karolinska Institutet|eI4Africa 13/11/2013- 6
Proposed members of the e- pharmacological sciences community to participate in the Africa Grid Science Gateway project AiBST (African Institute of Biomedical Science & T echnology www.aibst.com, Zimbabwe , Collen Masimirembwa Jaran Eriksen| Karolinska Institutet|eI4Africa 13/11/2013 - 7
Potential resources at the gateway Tools for ■ Genomics and bioinformatics ■ Pharmacokinetics/pharmacometrics ■ Bioanalysis, drug analysis and metabolism ■ Clinical trial sciences ■ Electronic library of publications and basic software packages such as statistics ■ Platform for multimedia contacts and e-learning tools Jaran Eriksen| Karolinska Institutet|eI4Africa 13/11/2013- 8
info@ei4africa.eu www.ei4africa.eu 9
Resources at the gateway Tools for ■ Genomics and bioinformatics: ClustalW ( www.ebi.ac.uk/Tools/phylogeny/clustalw2_phylogeny/ ) G-HMMER ( sgw.africa-grid.org/g-hmmer ) GROMACS ( sgw.africa-grid.org/gromacs ) BLAST ( blast.ncbi.nlm.nih.gov/ ) The Human Cytochrome P450 ( CYP ) Allele Nomenclature Database (www.cypalleles.ki.se/) ■ Pharmacokinetics/pharmacometrics: ■ Share information on laboratory analysis – send samples for analysis (e.g. MUHAS and Makerere) Jaran Eriksen| Karolinska Institutet|eI4Africa 13/11/2013- 10
Resources at the gateway II Tools for ■ Bioanalysis, drug analysis and metabolism: ■ http://www.uppsala-pharmacometrics.com/software. html including Nonmem for sparse pharmacokinetic/dynamic analyses available at http://psn.sourceforge.net/ ■ Xpose application for Nonmem at http://xpose.sourceforge.net ■ Population Experimantal Design at http://poped.sourceforge.net/ ■ onolix, software for pharmacometric work: www.lixoft.com ■ http://www.summitpk.com/tools/tools.htm ■ Clinical trial sciences: ■ The website clinicaltrials.gov (US governmental website over registered clinical trials) ■ The toolkit for writing clinical trial protocol www.ct-toolkit.ac.uk/rotuempa/protocol-development ■ SPIRIT 2013- Standard Protocol Items (presented at annals.org/ article.aspx? articleid= 1556168 and explained at www.bmj.com/content/346/bmj.e7586.pdf%2Bhtml Jaran Eriksen| Karolinska Institutet|eI4Africa 13/11/2013- 11
Resources at the gateway III ■ Electronic library of publications and basic software packages such as statistics ■ Platform for multimedia contacts and e-learning tools Jaran Eriksen| Karolinska Institutet|eI4Africa 13/11/2013- 12
Drug MANAGEMENT APPLICATION (DMA) Jaran Eriksen| Karolinska 13/11/2013- 13 Institutet|eI4Africa
Jaran Eriksen| Karolinska Institutet|eI4Africa 13/11/2013- 14
Jaran Eriksen| Karolinska Institutet|eI4Africa 13/11/2013- 15
Jaran Eriksen| Karolinska Institutet|eI4Africa 13/11/2013- 16
Jaran Eriksen| Karolinska Institutet|eI4Africa 13/11/2013- 17
Jaran Eriksen| Karolinska Institutet|eI4Africa 13/11/2013- 18
Jaran Eriksen| Karolinska Institutet|eI4Africa 13/11/2013- 19
Jaran Eriksen| Karolinska Institutet|eI4Africa 13/11/2013- 20
Jaran Eriksen| Karolinska Institutet|eI4Africa 13/11/2013- 21
Jaran Eriksen| Karolinska Institutet|eI4Africa 13/11/2013- 22
info@ei4africa.eu www.ei4africa.eu 23
Recommend
More recommend
