The eI4Africa EU/FP7 Project Exploiting e-Infrastructures potential - - PowerPoint PPT Presentation

The eI4Africa EU/FP7 Project Exploiting e-Infrastructures potential to boost RTDI in Africa

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African Pharmacological Science Gateway

Jaran Eriksen| Karolinska Institutet|eI4Africa 13/11/2013- 2

Background/Rationale

■Previous North-South Scientific and Technology transfer drive has not achieved the technology transfer hoped for  trained African scientists failing to continue their work upon returning to their home institutions ■Challenges: ■brain drain from Africa ■lack of scientific development ■A few successful groups set up competence in key research areas important for drug discovery, development and rational use of medicines ■Remain scientifically isolated with minimal possibilities for South-South interaction to build on the knowledge and technical skills they have individually established ■ Need for strengthened S-S collaboration in this field

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African Pharmacological Science Gateway

Objectives ■Design, develop, test, implement and evaluate a concept for cost- effective virtual e-infrastructure collaboration for African medical sciences focusing on the needs of pharmacological sciences and clinical trials for improving African healthcare:

■ Genomics and bioinformatics ■ Pharmacokinetics/pharmacometrics ■ Bioanalysis, drug analysis and metabolism ■ Clinical trial sciences

■Areas important in drug development and rational use of medicines  should be carried out in collaboration across countries ■All tools and collaborative platforms for this knowledge sharing should be available at the Africa Grid Science Gateway ( http://sgw.africa-grid.org/) as a pharmacological gateway

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Strengthening capacity and capability for drug development and rational use of medicines in Africa

■Ensuring continued laboratory based pharmacological research in Africa by enabling access to tools for analyzing and calculating data, and to expertise in these areas  reduce brain drain and unnecessary visits to US/Europe ■Continued contact, mentorship and access to necessary tools ■Strong capacity to maintain contacts between African laboratory based pharmacological scientists  stimulate establishment of strong clinical pharmacological research in African countries

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Properties of shared tools

■Tools simplifying collaboration across institutions within and outside Africa for basic and clinical drug research ■The virtual collaborative community should build on easily accessible tools that interested partners can gain access to ■Open access tools and solutions ■Establishment of technical competence for maintenance and development

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Proposed members of the e- pharmacological sciences community to participate in the Africa Grid Science Gateway project

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AiBST (African Institute of Biomedical Science & T echnology www.aibst.com, Zimbabwe , Collen Masimirembwa

Potential resources at the gateway

Tools for ■Genomics and bioinformatics ■Pharmacokinetics/pharmacometrics ■Bioanalysis, drug analysis and metabolism ■Clinical trial sciences ■Electronic library of publications and basic software packages such as statistics ■Platform for multimedia contacts and e-learning tools

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Resources at the gateway

Tools for ■Genomics and bioinformatics:

 ClustalW (www.ebi.ac.uk/Tools/phylogeny/clustalw2_phylogeny/) 

G-HMMER (sgw.africa-grid.org/g-hmmer)

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GROMACS (sgw.africa-grid.org/gromacs)

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BLAST (blast.ncbi.nlm.nih.gov/)

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The Human Cytochrome P450 (CYP) Allele Nomenclature Database (www.cypalleles.ki.se/)

■Pharmacokinetics/pharmacometrics:

■ Share information on laboratory analysis – send samples for analysis (e.g. MUHAS and Makerere)

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Resources at the gateway II

Tools for ■Bioanalysis, drug analysis and metabolism:

■ http://www.uppsala-pharmacometrics.com/software. html including Nonmem for sparse pharmacokinetic/dynamic analyses available at http://psn.sourceforge.net/ ■ Xpose application for Nonmem at http://xpose.sourceforge.net ■ Population Experimantal Design at http://poped.sourceforge.net/ ■ onolix, software for pharmacometric work: www.lixoft.com ■ http://www.summitpk.com/tools/tools.htm

■Clinical trial sciences:

■ The website clinicaltrials.gov (US governmental website over registered clinical trials) ■ The toolkit for writing clinical trial protocol www.ct-toolkit.ac.uk/rotuempa/protocol-development ■ SPIRIT 2013- Standard Protocol Items (presented at annals.org/ article.aspx? articleid= 1556168 and explained at www.bmj.com/content/346/bmj.e7586.pdf%2Bhtml

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Resources at the gateway III

■Electronic library of publications and basic software packages such as statistics ■Platform for multimedia contacts and e-learning tools

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Drug MANAGEMENT APPLICATION (DMA)

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