The DiaGene: a prospective case-control study Sunny Singh Badal MD, - - PowerPoint PPT Presentation

The DiaGene: a prospective case-control study

Sunny Singh Badal MD, PHD student Department: Vascular Medicine

Type 2 Diabetes Mellitus (T2DM)

• RIVM: Rising prevalence and incidence
• Prevalence 2017: 1135100
• Incidence 2017: 60200
• Still high percentage develop complications

Methods

• DiaGene study
• Multicenter prospective case-control study
• DM2 cases, healthy controls
• Eindhoven: Maxima Medisch Centrum,

Catharina Hospital, Diagnostic Center Eindhoven (General practioners)

Van Herpt, Thijs T. W. et al. “Introduction of the DiaGene Study: Clinical Characteristics, Pathophysiology and Determinants of Vascular Complications of Type 2 Diabetes.” Diabetology & Metabolic Syndrome 9 (2017): 47. PMC. Web. 16 July 2017

Methods

DM, diabetes mellitus; MODY, Maturity-Onset Diabetes of the Young; Latent Auto-immune Diabetes of the Adult

Statistics

Endpoints

Macrovascular complications: Ischemic brain disease, ischemic heart disease. PAD etc. Microvascular complications

• Retinopathy, nephropathy, neuropathy, composite endpoint

Genetic associations with incident and prevalent complications will be assessed