Tel: (202) 444-0275 Fax: (202) - PowerPoint PPT Presentation

Oct 31, 2022 •127 likes •336 views

�� Tel: (202) 444-0275 Fax: (202) 444-1229 http://lombardi.georgetown.edu/GI
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�� Chemo + Cetuximab �� OS = 29.9 mos PFS = 10.4 mos �� Chemo + Bevacizumab �� OS = 29.0 mos �� PFS = 10.8 mos ��
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�� Median HR Side N (Events) p (95% CI) (95% CI) 33.3 Left 732 (550) 1.60 (31.4-35.7) <0.001 19.4 ( 1.37-1.86) Right 293 (242) (16.7-23.6) ��
�� Median HR Side N (Events) p (95% CI) (95% CI) 36.0 1.99 Left 376 (270) <0.001 (32.6-40.3) (1.60-2.46) 16.7 Right 143 (121) (13.1-19.4) ��
RAS MSI BRAF PIK3CA PTEN RAS KRAS HER2/NEU APC TP53 RAS KRAS HER2/NEU APC TP53 �� 2017 The Ruesch Center for the Cure of GI Cancers
NCCN Nov 2016 • “There is a preponderance of data to suggest lack of activity of cetuximab and panitumumab in initial therapy of patients whose primary tumors originated on the right side of the colon”
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Basic Principles Adjuvant Metastatic Strategy Curative Palliative Target Mesenchymal Cells Epithelial Cells Drugs 5FU/Capecitabine 5FU/Capecitabine Oxaliplatin Oxaliplatin Irinotecan VEGF EGFR TAS-102 Regorafanib Duration No more than 6 months Treat to progression Maintenance therapy
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