Taste Related Brain Activity in Thermal Tasters Compared to Thermal - - PowerPoint PPT Presentation

▶
taste related brain activity in thermal
SMART_READER_LITE
LIVE PREVIEW

Taste Related Brain Activity in Thermal Tasters Compared to Thermal - - PowerPoint PPT Presentation

Mar 09, 2024 212 likes •396 views

Measuring Temperature and Phantom Taste Related Brain Activity in Thermal Tasters Compared to Thermal non Tasters M. Skinner* 1,2 , S. Eldeghaidy 2 , R. Ford 1 , M. Hoeksma 3 , T. Giesbrecht 4 , A. Thomas 4 , S. Francis 2 , J. Hort 1 . 1 Sensory

slide-1
SLIDE 1

Providence RI, USA 20-24 August 2017

Measuring Temperature and Phantom Taste Related Brain Activity in Thermal Tasters Compared to Thermal non Tasters

  • M. Skinner*1,2, S. Eldeghaidy2, R. Ford1, M. Hoeksma3,
  • T. Giesbrecht4, A. Thomas4, S. Francis2, J. Hort1.

1Sensory Science Centre, University of Nottingham, UK. 2Sir Peter Mansfield Imaging Centre, University of Nottingham, UK. 3Unilever R&D, Vlaardingen, Netherlands. 4Unilever R&D, Port Sunlight, UK.

slide-2
SLIDE 2

What is thermal taster status?

Thermal taste phenotypes

  • Thermal taster (TT)
  • Thermal non taster (TnT)
  • Metallic
  • Minty
  • Spicy
  • Umami

WARMING stimuli COOLING stimuli

Bitter Sour

TTs are more sensitive to oral stimuli

  • Taste
  • Trigeminal

(Green & George, 2004, Yang et al., 2014)

Sweet

Food Choice?

2

(Cruz & Green, 2000) (Yang et al., 2014)

Up to 50% TTs

Salt

slide-3
SLIDE 3

Exploring thermal taste phenotypes

Multidisciplinary approach

  • Sensory Science & functional Magnetic Resonance Imaging (fMRI)

Perceptual response

  • Captured by sensory evaluation techniques

Brain activation

  • Captured by fMRI techniques

3

  • Brain activation maps show areas of the

brain involved in the response to a stimulus

slide-4
SLIDE 4

Study aims

Perceptual response

  • Can we identify the temperature range at which phantom

taste is perceived during temperature stimulation?

  • Does this differ across TTs?

Brain response

  • Do we see activation in the gustatory cortex when phantom

taste is reported by TTs?

  • Is there a difference in temperature related brain activation in

the somatosensory cortex across thermal taste phenotypes?

4

Identify mechanisms involved in the phantom taste response?

slide-5
SLIDE 5

Thermal taste phenotyping

  • Classify TTs/TnTs (Bajec and Pickering, 2008)
  • Measure perceived temperature intensity

Warming trial Cooling trial

2 replicates Recruited

  • 12 TTs/12 TnTs

5 General labelled magnitude scale (gLMS)

slide-6
SLIDE 6

Modified phantom taste testing

10 replicates Temporal taste response

6

40°C trial Rating Rating 5°C trial

slide-7
SLIDE 7

Phenotyping Results

7

Warming trial Cooling trial

(Cruz and Green, 2000) (Yang et al., 2014)

slide-8
SLIDE 8

8

Reproducibility of phantom taste

  • Phantom taste is reproducibly reported across replicates
  • Phantom taste is perceived at a specific temperature range

Taste intensity rating

slide-9
SLIDE 9

Inter-individual responses (TTs)

9

Mean of 10 replicates

Taste intensity ratings

slide-10
SLIDE 10

Inter-individual responses (TTs)

10

The temperature range at which phantom taste is perceived is highly variable across TTs

Taste intensity ratings

Mean of 10 replicates

slide-11
SLIDE 11

fMRI brain imaging

  • 3 T Philips Achieva scanner, 32-element SENSE head coil
  • fMRI data acquired with double-echo gradient EPI (TE: 20 ms, 45 ms),

3mm3 isotropic voxel size, 36 transverse slices, TR = 2.5 s

11

slide-12
SLIDE 12

fMRI testing

Control task

12

40°C trial 5°C trial

Subject 08 Subject 08

Temperature (°C) gLMS intensity rating gLMS intensity rating Time (sec) Time (sec)

slide-13
SLIDE 13

Phantom taste related brain activation (12 TTs)

13

Brain activation in regions associated with taste processing in TTs

Taste cortex (anterior insula)

Are gustatory nerve fibres activated by temperature in TTs?

Is ‘phantom’ taste really a phantom?

fMRI data analysed by Dr Sally Eldeghaidy-Sir Peter Mansfield Imaging Centre, UoN

slide-14
SLIDE 14

Cortical activation TTs > TnTs

Temperature response across thermal taste phenotypes (12 TTs & 12 TnTs)

14

TTs have greater temperature related brain activation than TnTs

Oral somatosensory areas

fMRI data analysed by Dr Sally Eldeghaidy-Sir Peter Mansfield Imaging Centre, UoN

slide-15
SLIDE 15

Conclusions

  • The temperature range at which TTs perceive

phantom taste during thermal stimulation is variable

  • Brain regions associated with taste processing are

activated in response to temperature stimulation in TTs, accounting for the perceived ‘phantom’ taste

15

  • TTs have greater temperature related brain activation

in oral somatosensory areas of the brain than TnTs These findings support the hypothesis that cross wiring between gustatory and trigeminal nerve fibres innervating the papillae may be involved

(Cruz and Green, 2000, Hort et al, 2016)

slide-16
SLIDE 16

Implications and future directions

16

Implications

  • Impact of TT status on product perception, food choice,

nutritional status and health outcomes

  • Heightened oral sensitivity exhibited by TTs
  • Phantom tastes perceived

Future directions

  • Mechanisms associated with thermal taster status
  • Isolate the temperature range of phantom taste responses
  • Understanding non-prototypical ‘taste’ sensations
  • Utilising fMRI to understand cortical processing
slide-17
SLIDE 17

SSC

  • Joanne Hort
  • Rebecca Ford
  • Martha Skinner

Acknowledgments

Thank you for your attention!

SPMIC

  • Susan Francis
  • Sally Eldeghaidy

Unilever

  • Anna Thomas
  • Timo Giesbrecht
  • Marco Hoeksma

www.nottingham.ac.uk/biosciences/research/research-themes/taste-map/taste-map.aspx

17