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Stephen Lagakos and the New England Statistical Consulting at NEJM : - - PowerPoint PPT Presentation
Stephen Lagakos and the New England Statistical Consulting at NEJM : - - PowerPoint PPT Presentation
Stephen Lagakos and the New England Statistical Consulting at NEJM : 1997 2009 Journal of Medicine Gregory Curfman, M.D. Executive Editor, New England Journal of Medicine Statistical Consulting at NEJM : 1997 2009 Statistical Consulting at
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Statistical Consulting at NEJM: 1997‐2009
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Statistical Consulting at NEJM: 1997‐2009
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Statistical Consulting at NEJM: 1997‐2009
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1812: The New England Journal
- f Medicine and Surgery, and the
Collateral Branches of Science established. 1823: The Medical Intelligencer established. 1828: The two journals merged into the weekly Boston Medical and Surgical Journal. 1928: The journal adopted its current name, The New England Journal of Medicine.
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John Collins Warren, M.D. Editor‐in‐Chief
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Yearly submissions: 6,646 Acceptance rate: 6% Research articles: 225 published/year Readers: 600,000/weekly issue Current impact factor: 47.05 Articles on:
- Clinical Medicine
- Translational Medicine
- Health Policy
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Statistical Consulting at NEJM: 1997‐2009 History of Statistical Consulting at NEJM
1979 Lawrence Thibodeau becomes the first statistical
- consultant. (1 consultant)
1980 John Bailar replaces Thibodeau. (1 consultant) 1987 Walter Willett joins Bailar. (2 consultants) 1991 Bailar
- leaves. Frederick Mosteller
and James Ware are hired. (3 consultants) 1992 Mosteller
- leaves. Alexander Walker is hired, and
The W’s form. (3 consultants)
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Statistical Consulting at NEJM: 1997‐2009 Who Are the W’s?
Walter Willett, MD James Ware, PhD Alexander Walker, MD
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Statistical Consulting at NEJM: 1997‐2009
1996 Walker leaves. (2 consultants) 1997 Stephen Lagakos is hired. (3 consultants) 2000 David Hunter is hired. (4 consultants) 2001 Willett leaves. (3 consultants) 2007 Ralph D’Agostino is hired. (4 consultants) 2010 David Harrington is hired. (4 consultants)
History of Statistical Consulting at NEJM
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Statistical Consulting Process
- Articles with statistical content reviewed at initial submission.
- Most revised articles reviewed a second time.
- For clinical trials: review of protocol and clinicaltrials.gov.
- Review requires 1.5 hours on average.
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Statistician’s Role: Comprehensive Review
- Study design: assess appropriateness.
- Study conduct: assess aspects that have implications for the
validity of study and strength of findings.
- Data analysis: assess appropriateness and validity, review for
consistency with protocol.
- Conclusions: assess validity of conclusions reached by
investigators.
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Statistical Consulting at NEJM: 1997‐2009 Contributions of Dr. Lagakos to NEJM
- Statistical Consultant
- Statistics in Medicine
- Research
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Statistical Consulting at NEJM: 1997‐2009 Statistical Consultant at NEJM, 1997‐2009
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Work Product
- 740 published manuscripts reviewed
- Approximately 60 published manuscripts
per year
- More than 1 article per weekly issue
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Contributions in Infectious Disease
- Antiretroviral therapy: defining surrogates
- Mother‐to‐child transmission of HIV
- New antiinfective
drugs
- Vaccines: HIV, malaria, HPV
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Statistical Consulting at NEJM: 1997‐2009
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Statistical Consulting at NEJM: 1997‐2009 Statistics and Medicine
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Statistical Consulting at NEJM: 1997‐2009 Statistics and Medicine
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Statistical Consulting at NEJM: 1997‐2009 Research : Zidovudine
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Statistical Consulting at NEJM: 1997‐2009 Research : HIV/AIDS
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Statistical Consulting at NEJM: 1997‐2009 Commentary : HIV/AIDS
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Statistical Consulting at NEJM: 1997‐2009 Commentary : HIV/AIDS
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Statistical Consulting at NEJM: 1997‐2009 Statistical Consultant at NEJM, 1997‐2009
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