Smoking and Risk of Childhood B- -cell ALL cell ALL Smoking and - - PowerPoint PPT Presentation

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Smoking and Risk of Childhood B Smoking and Risk of Childhood B-

• cell ALL

cell ALL

756 cases 756 cases-

• 1226 controls

1226 controls

Active Active Smoker Smoker Timing Timing Exposed Exposed Cases Cases Exposed Exposed Controls Controls OR OR 95% CI 95% CI Father Father1 Pre Pre-

• conception (yes/no)

conception (yes/no) 200 200 273 273 1.19 1.19 0.95 0.95-

• 1.48

1.48 (#CPD) (#CPD)

• 1.02*

1.02* 1.00 1.00-

• 1.03

1.03 Mother Mother2 Pre Pre-

• conception (yes/no)

conception (yes/no) 102 102 149 149 0.67 0.67 0.39 0.39-

• 1.15

1.15 (#CPD) (#CPD)

• 1.02

1.02 0.98 0.98-

• 1.07

1.07 Pregnancy (yes/no) Pregnancy (yes/no) 72 72 97 97 1.21 1.21 0.71 0.71-

• 2.07

2.07 (#CPD) (#CPD)

• 0.97

0.97 0.91 0.91-

• 1.04

1.04 Any Any3 After birth (yes/no) After birth (yes/no) 174 174 205 205 1.29* 1.29* 1.02 1.02-

• 1.64

1.64

CPD: Cigarettes Per Day; ORs adjusted for child’s age, sex, Hispanic status, maternal race, and annual household income. 1n=691 ALL due to delay in collecting data; 2OR adjusted for postnatal maternal smoking and birth weight; 3Include mother, father, or others.

No increased risk observed for T-cell ALL (n=76)

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Results by Major Cytogenetic Subtype of Childhood B-cell ALL

t(12:21) t(12:21)

n=133 n=133

Hyperdiploidy Hyperdiploidy

n=228 n=228 Smoker Smoker Timing Timing OR OR 95% CI 95% CI OR OR 95% CI 95% CI Father Father1 Pre Pre-

• conception (yes/no)

conception (yes/no) 1.41 1.41 0.92 0.92-

• 2.16

2.16 0.94 0.94 0.66 0.66-

• 1.34

1.34 (#CPD) (#CPD) 1.03* 1.03* 1.01 1.01-

• 1.06

1.06 1.00 1.00 0.98 0.98-

• 1.03

1.03 Mother Mother2 Pre Pre-

• conception (yes/no)

conception (yes/no) 0.63 0.63 0.23 0.23-

• 1.77

1.77 0.69 0.69 0.30 0.30-

• 1.57

1.57 (#CPD) (#CPD) 1.00 1.00 0.91 0.91-

• 1.11

1.11 1.04 1.04 0.98 0.98-

• 1.10

1.10 Pregnancy (yes/no) Pregnancy (yes/no) 1.54 1.54 0.60 0.60-

• 3.93

3.93 1.09 1.09 0.47 0.47-

• 2.51

2.51 (#CPD) (#CPD) 0.95 0.95 0.85 0.85-

• 1.05

1.05 0.96 0.96 0.87 0.87-

• 1.06

1.06 Any Any3 After birth (yes/no) After birth (yes/no) 1.96* 1.96* 1.28 1.28-

• 3.00

3.00 0.97 0.97 0.66 0.66-

• 1.42

1.42

CPD: Cigarettes Per Day; ORs adjusted for child’s age, sex, Hispanic status, maternal race, and annual household income. 1Delay in collecting data; 2OR adjusted for postnatal maternal smoking and birth weight; 3Include mother, father, or others.

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Joint E ffect of Smoking on Risk of B Joint E ffect of Smoking on Risk of B-

• cell ALL

cell ALL

Smoking exposure Father preconception Any smoker, after birth Cases/Controls OR* (95% CI) No No 443/830 Reference No Yes 93/160 0.96 (0.72-1.28) Yes No 44/88 0.84 (0.57-1.23) Yes Yes 103/109 1.45 (1.07-1.97)**

*ORs adjusted for child’s age, sex, Hispanic status, maternal race, and annual household income; **P-value for

interaction=0.017

Same observation for B-Cell ALL with t(12;21)

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Child Child’ ’s Passive Smoking and s Passive Smoking and Risk of Childhood AML Risk of Childhood AML

Exposed Exposed Cases Cases Exposed Exposed Controls Controls OR OR 95% CI 95% CI AML, total (n=145) AML, total (n=145) 42 42 205 205 1.49 1.49 0.98 0.98-

• 2.26

2.26 AML, AML, “ “good prognosis good prognosis” ”1

1 (n=40)

(n=40) 14 14 205 205 1.94 1.94 0.94 0.94-

• 3.99

3.99 AML, other cytogenetic changes (n=75) AML, other cytogenetic changes (n=75) 20 20 205 205 1.24 1.24 0.70 0.70-

• 2.19

2.19

ORs adjusted for child’s age, sex, Hispanic status, maternal race, and annual household income.

1Any translocation involving chromosome 21, t(15;17) or inversion

Any translocation involving chromosome 21, t(15;17) or inversion (16) (16)