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- Introduction
- Closed loop smart medical devices
- Smart dressing for the wound care management:
- Smart closed-loop wound dressing
- Biotextile wound dressing for drug delivery
- Micorneedle based wound dressing
- Conclusion
2
Outline
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Smart Medical Devices: Nano-enabled Sensors, Electronics, and - - PowerPoint PPT Presentation
Smart Medical Devices: Nano-enabled Sensors, Electronics, and - - PowerPoint PPT Presentation
Smart Medical Devices: Nano-enabled Sensors, Electronics, and On-demand Drug Delivery Pooria Mostafalu April 2019 Outline Introduction Closed loop smart medical devices Smart dressing for the wound care management: o Smart
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www.yol.fr
Introduction
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Current approach: Regular screening
- Expensive
- Inhibit early screening
- Inaccuracy
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Closed-loop Smart Devices
- Smart platform transmits healing factor information via Bluetooth to a mobile
device which uploads the data to a cloud.
- Healthcare providers can remotely monitor healing and modify treatment if
necessary.
Cloud Wi-Fi Bluetooth Treatment modification Physician Internet provider Smart device
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Problem: Chronic Wounds
Chronic wound treatment places a heavy cost and resource burden on the health care system, costing over $50 billion annually in the US. 25% of infected chronic wounds lead to
- amputation. Chronic wounds are the
leading cause of non-traumatic limb amputation.
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Wound Healing Pathway
- pH, oxygen, and proinflammatory cytokines are key markers for monitoring
- f wound healing.
- Antibiotics, growth factors, and immune regulating drugs are essential.
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Alginates Hydrogels Foams Hydrocolloid Transparent Film
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State-of-the-art in Current Wound Dressings
Current dressings :
- Maintain moisture balance
- Remain in place but not adherent to wound bed
- Minimize shear, friction, skin irritation, and additional pressure
Continuous monitoring and treatment is not available.
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Smart Flexible Wound Dressing
- P. Mostafalu, et al. (2018) . Small
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Smart Textile Dressing
- An active wound dressing was fabricated using composite fibers with a core electrical
heater covered by a layer of hydrogel containing thermo-responsive drug carriers.
- This biotextile dressing can deliver biomolecules with a pre-determined spatial and
temporal delivery ability.
- P. Mostafalu, et al. (2017) . Advance Functional Materials
- P. Mostafalu, et al. (2018) . Nature Microsystem and Nanoengineering
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Smart Microneedle-based Dressing
Needle-based bandage Electronic board
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Highlighted Results
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- P. Mostafalu, et al. (2019) . science advances
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Conclusion
- A better treatment outcome, clinical practice should decide about “what”, “when”, and
“where” you should deliver a drug.
- Sensors allows that what kind of treatment should be delivered.
- Electronic system can be used to readout the data and make the decision when the
treatment should be applied.
- Stimuli responsive drug delivery enables electronic system to adjust the treatment.