Signal Processing and Data Analysis 2005-2008 21 st July 2008
Members 2008 4 PhD, 3 PosDoc (2 - Ciência 2007) , 2 PhD Stud • 2005 – (PhD , FCUP ) , PI Ana Paula Rocha – Argentina Leite (PhD stud , FCUP and UTAD ) – (PhD stud FCT , European PhD) Sónia Gouveia – Rute Almeida (PhD stud FCT , European PhD) • 2006 – Ana Rita Gaio (PhD, FCUP ) – ( European PhD concluded) Rute Almeida • 2007 – Helena Brás Silva (PhD, IPP) – J. Pinto da Costa (PhD, FCUP) – Rute Almeida (Pos Doc CiberBBN, Zaragoza) • 2008 (May) – Paulo Aguiar (Pos Doc Ciência 2007, CMUP) – Murilo Baptista (Pos Doc Ciência 2007, CMUP)
Research Lines • Biomedical Signals and Systems Case Study: cardiovascular signals analysis – Study of the ECG, multimodal cardiovascular variability and cardiorespiratory coupling – Time, frequency, time/scale (wavelets), linear and non linear analysis – Time variant modeling: Long-range / short term dependency in HRV (ARFIMA ) • Statistical Modeling in the Health Sciences Case Study: nutritional and rheumatic epidemiology – Classification techniques on continuous data: dietary patterns construction – Latent variable models: knowledge of rheumatic disease versus health status • Statistical Learning – Classification of ordinal data. Graph theory based clustering. – Weighted measures in classification. Weighted PCA. • Bioinformatics/Biomathematics – Computational Neuroscience – Information/synchronization in active networks. Complex systems analysis. • Scientific Consultancy (joint publications)
Collaborations • Technical and Scientific – Italy: Mortara Rangoni / Portugal,CardioSolutions – Spain: Univ Zaragoza, Communication technologies Group, Ciber BBN – UK: Univ Edinburgh, Institute for Adaptive and Neural Computation – USA/Brasil: Univ Illinois / Univ S. Paulo – Germany: Univ. Potsdam and Max Plank Institute PKS – Portugal: FEP, UP and UIMA, UA; INESC • Clinical and Experimental – Belgium: Hospital Erasmus, Brussels – Portugal: FMUP and Hospital S. João (HSJ) Porto • SCIIP, Serviço de Cuidados Intensivos e Intermédios em Pediatria, HSJ • Laboratório de Sono, Serviço Pneumologia HSJ, Porto • Serviço de Higiene e Epidemiologia • Instituto Histologia e Embriologia – Portugal: FFUP (Serviço de Tecnologia Farmacêutica e Serviço de Toxicologia) – Portugal: IBMC (Instituto de Biologia Molecular e Celular) • Grupo de Neurobiologia Básica e Clínica
Achievements - Publications • 2005-2006 – 7 Papers in international peer reviewed Journals (ISI, IP Impact Factor 2006) - Neuroscience IP=3.427 - IEEE Transactions on Biomedical Engineering IP=2.302 - Physiological Measurement IP=1.438 - Medical and Biological Engineering and Computing IP=1.018 - Digital Signal Processing IP=0.889 - Biomedizinischie Technik IP=0.835 - Journal of Sensory Studies IP=0.794 – 6 Papers in Proceedings of International Conferences ( 5 ISI Proceedings) • 2007-2008 – 8 Papers in international peer reviewed Journals - Journal of Machine Learning Research IP=2.255 - Neural Networks IP=2.000 - Ecotoxicology and Environmental Safety (in press) IP= 2.000 - Early Human Development (2; 1 in press, on line) IP=1.738 - Journal of Sensory Studies ; IP=0.794 - Australian & New Zealand Journal of Statistics IP=0.347 - Cardiovascular & Haematological Disorders-Drug Targets – 13 Papers in Proceedings of International Conferences
Graduate StudentsTraining • 2005-2006 – PhD (3; 2 European Phd, 1 concluded ) - Applied Mathematics (1 European Phd concluded 2006), AP Rocha – MSc (3) - Computational Methods in Science and Engineering – 2005, AP Rocha - Statistics – 2005, AP Rocha - Mathematical Engineering - 2006, AR Gaio • 2007-2008 – PhD (5 , 2 concluded, 1 European Phd ongoing ) - Computer Science – 2 - 1 concluded 2007, J Pinto da Costa - Applied Mathematics - 2 - 1 waiting for Viva, 1 European Phd - AP Rocha - Public Health - 1- AR Gaio – MSc ( 7 , 3 concluded ) - Bioinformatics - 1 – concluded 2007, AP Rocha - Mathematical Engineering - 2 - concluded 2007, ARGaio / J.Pinto da Costa - Statistics - 1 , J.Pinto da Costa - Mathematical Engineering -3, J.Pinto da Costa - Medical Physics -1, AP Rocha
Pre-Graduate StudentsTraining • 2005-2006 Program: Scientific Research in Pre-Graduation. U Porto. – Distinction Award, March 2005 , project Diabetes Mellitus: Early signs in the pré-sintomatic phase of the autonomic disfunction Funding: Univ Porto / Fundação Ilídio Pinho. (1 student: FCUP) – Cardiovascular variability analysis in critical illness: follow-up and outcome. Funding: Univ Porto / Caixa Geral Depósitos (CGD). (9 students: 5 FCUP, 4 FMUP). • 2007-2008 Program: Scientific Research in Pre-Graduation. Pluridisciplinary Projects 2007. Funding: Univ Porto / CGD - Multimodal analysis in pediatric coma (4 students: 3 FCUP, 1 FMUP). - Arterial Blood Pressure responses and Heart Rate variability: role in the diagnosis and prognosis of Sleep Disordered Breathing (2 students: FCUP). • 2008-2009 FCT Ciência 2008 BII (research integration of 5000 1st cicle students) CMUP Call Posted EraCareers, July 2008
Networking/Research Projects • 2005-2006 – Tachografic, Spectral and Fractal analysis of heart rate variability in pre and pos natal life. Application in medical diagnostics and educational systems. Ref: POSI/CPS/40153/2001 (2002 – 2006). Funding: 55 000 € ( 21 628 € at FCUP ). Involved Institutions: FEUP/INEB (Coordination), FCUP, FMUP. CMUP Team: AP Rocha. – Tratamiento de señal en el análisis del ECG y polisomnografía: Procesado orientado por el modelado fisiológico. Ref: CYCT/FEDER TEC2004-05263-C02-02, (Spain, 2004- 2007) . Funding: 123 200 € . Involved Institutions: Zaragoza Uiversity (Spain, Coordination), FCUP (Portugal), Univ. Zaragoza, Hospital Miguel Servet, Zaragoza (Spain), Lund University (Sweden), Favaloro University (Argentina), Saint George Hospital, London (UK), Nice University (France). CMUP Team: AP Rocha, RB Almeida • 2007-2010 - Analisis multimodal-multicanal e interpretacion fisiológico diagnostica de señales biomedicas del sistema cardiovascular, respiratorio autonomico y del sueño: variabilidad dynamica e interacciones Funding 215 351 € . Ref: CYCT/FEDER - TEC2007-68076-C02-02(Spain, 2007- 2010). Extension of TEC2004-05263-C02-02. Innovation and links to foreign centers as Duke University Medical Center (USA), MIT (USA), Medtronics research center (Holland). CMUP Team: AP Rocha, S Gouveia, RB Almeida (Ciber BBN)
Research 2007-2010 • Biomedical Signals and Systems Cardiovascular signals analysis and risk stratification – Improved Multilead Wavelet ECG delineation and Cardiorespiratory coupling characterization. – Correntropy as complementary to time, frequency, time/scale, linear and non linear analysis. – Novel approaches in long-term and non stationary HRV modeling: volatility (ARFIMA-GARCH) • Statistical Modeling in the Health Sciences Case Studies from epidemiology and public health – Classification techniques on ordinal data: dietary patterns construction – Latent mixture variable models: detection of cardiac failure • Statistical Learning – Classification of ordinal data. Graph theory based clustering. – Weighted measures in classification. Weighted PCA. • Bioinformatics/Biomathematics – Computational Neuroscience: neural connectivity/network architecture, activity level control in spiking networks, learning and memory models… – Information/synchronization in active networks. Complex systems analysis versus dynamic systems tools • Ciência2008 – Joint Call 2 Pos Doc Positions - Statistical Analysis and Applications
Case Study Biomedical Signals and Systems Cardiovascular signals analysis and risk stratification
ECG automatic delineation Beat-to-beat variability series using Wavelet methodologies RR analysis / Heart Rate Variability ECG Variabilities interactions Characterization in Ambulatory Follow-up and prognosis in QT variability driven by RR and Long term Critical Care Bedside 24 hours
Multimodal analysis for the characterization of the cardiovascular system Sleep as a cardiovascular frontier Goal: Understanding of the ANS Sleep apnea studies Invasive and drug induced experiments Polissonography study • ECG and Arterial Blood Pressure • Thorax respiratory effort sensors • Nasal Flow Channels • ECG and Arterial Blood Pressure • Respiration • Oxygen saturation • Muscular Sympathetic Neural Activity • EEG, EOG, EMG, Body position sensors
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