Science-based grouping of nanoparticles for industrial application - PowerPoint PPT Presentation

Science-based grouping of nanoparticles for industrial application of safe-by-design Katarzyna Odziomek, Tomas Puzyn, Piotr Urbaszek, Andrea Haase, Christian Riebeling, Agnieszka Gajewicz, Muhammed A. Irfan, Robert Landsiedel, Meike van der Zande, and Hans Bouwmeester

Objective “ To bridge the Mode of Action based computational modelling to the demands of grouping and safe by design of nanoparticles, and make it applicable for industry”. 2

Are there (any) principles for grouping of NM?  ..not every chemical needs to be tested for every endpoint...overall data for that category should prove adequate to support a hazard assessment... (OECD, 2014)  Grouping should take into account all aspects of NM life cycle.. (Arts et al., 2014)  Structure and material properties, exposure, uptake and kinetics, initiating cellular effects or apical effects.. (ECETOC 2014) 3 Oomen et al 2014

Establishing science-based criteria for grouping 4 Adapted from Agnes Oomen et al. 2014 In „ Safety of nanomaterials along their life-cycle “ pp 358 – 379 ISBN 978-1-46-656786-3, 2014

ECETOC Grouping Strategy 5 Arts et al., 2015, A decision-making framework for the grouping and testing of nanomaterials (DF4nanoGrouping). Regul Toxicol Pharmacol. 2015 Mar 15;71(2 Suppl):S1-27. doi: 10.1016/j.yrtph.2015.03.007.

Grouping Concepts  No single property groups all materials – Need a multi-perspective grouping & testing strategy Refinement of grouping criteria Multi-perspective grouping 6

Tiered Testing 7

Panel of nanoparticles Name Size SizeDLSw SSA Zeta XPSC XPSNa 17.00 0.00 BaSO4.NM220 32.00 350.00 41.00 -39.00 CeO2 200.00 N/A 33.00 6.00 9.00 0.00 9.00 0.00 CeO2.Al 81.00 N/A 46.00 18.00 28.70 0.00 CeO2.NM211 12.00 N/A 33.00 16.00 CeO2.NM212 40.00 N/A 27.00 42.00 79.90 0.00 73.10 0.00 SiO2.NH3 15.00 42.00 200.00 0.00 SiO2.PEG 15.00 50.00 200.00 -26.00 73.60 0.00 SiO2.PO3 15.00 40.00 200.00 42.90 77.10 0.00 0.00 0.00 SiO2.UNMOD 15.00 40.00 200.00 -39.00 TiO2.NM105 50.00 478.00 51.00 -17.00 0.00 0.00 5.00 0.50 TiO2.TLSF 50.00 N/A 100.00 -3.00 4.00 1.00 ZrO2 42.50 N/A 24.90 -12.00 ZrO2.ACR 9.00 9.00 117.00 -39.00 9.00 0.50 9.00 0.00 ZrO2.NH3 10.00 315.00 105.00 -3.90 19.00 0.00 ZrO2.PEG 9.00 27.00 117.00 -7.80 ZrO2.TOD 9.00 9.00 117.00 -6.50 19.00 0.00 0.00 0.00 DPP.BULK 200.00 N/A 42.00 -11.40 DPP.NANO 400.00 N/A 64.00 -12.30 0.00 0.00 DPP.RED 43.00 N/A 30.00 -16.00 11.00 0.00 8

With variations in surface modifications 9