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SCBE 04: Enhancing Environmental Sustainability of Pharmaceutical - - PowerPoint PPT Presentation
SCBE 04: Enhancing Environmental Sustainability of Pharmaceutical - - PowerPoint PPT Presentation
SCBE 04: Enhancing Environmental Sustainability of Pharmaceutical Solid Dosage Form via Life Cycle Analysis Bian XinRan Ge Wen Xuan Introduction Pharmaceutical excipients: -Formulated alongside active ingredient of medication -No
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Pharmaceutical excipients:
- Formulated alongside active ingredient of medication
- No medicinal properties
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Environmental Sustainability:
- Rates of renewable resource harvest,
pollution creation and non-renewable resource depletion can be continued indefinitely
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Aim / hypothesis
- Aims: Analyse the impacts of excipients involved in solid
dosage forms on environment sustainability through LCA
- Hypothesis: Alginic acid is more
environmentally sustainable than calcium alginate
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Results and Discussion
Alginic Acid Calcium Alginate Similarity Difference Manufacture process till before addition of acid or calcium chloride to form each respectively.
Waste: Filter cake and Finals filtrate
- Resource that can be used which
are currently met through imports
- > Iodine (93-94% present
- riginally in seaweeds)
Waste
- Filter cake and Finals Filtrate
- Alkaline wastewater containing
calcium from the calcium precipitation and acid from the acid conversion step
- > pumped out and disposed
into sea
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Results and Discussion
Alginic Acid Calcium Alginate Short Term Long Term
Reduces the harm brought about through the reduced production of iodine to meet the same demand More positive effects on environment Cause harm to the aquatic environment as increasing the pH beyond its normal range will cause different extent of the following: killing of adult fish and invertebrate life directly, strip fish of its slime coat and even increase the toxicity
- f other substances.
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Manufacturing of alginic acid is more environmentally friendly than the manufacturing of calcium alginate.
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Future Work/ Applications
1.Replace the calcium alginate used as tablet binders in Paracetamol with alginic acid due to its high demand.
- 2. Further applied to other pharmaceutical solid dosage
forms.
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