RX-10 Enhance Your Jacketed Lab Reactor Beat Dietrich October 2015 - - PowerPoint PPT Presentation

RX-10

Enhance Your Jacketed Lab Reactor

Beat Dietrich October 2015

Content

• Jacketed Lab Reactor (JLR) Challenges
• RX-10 Overview
• Voice of the Customer

1

What is a JLR System?

2 Jacketed Lab Reactor PAT Probe Stirrer Temperature

Challenges with Traditional Lab Reactors

3

Inconsistent Controls Means time- consuming task of relearning controls Lost or Missing Data Failing to Document Leads to Repeat Experiments Manual Documentation and Reporting Time Consuming and Error Prone Manual Parameter Control Scientists must be in lab to change process parameters Increase waste of materials and time Lack of integration Increases risk of inconsistent results Inefficient use of resources and limited ability to run safe overnight experiments Bottlenecks post experiment delay timely decisions

Challenge 1: Inconsistent Controls

• Many different interfaces for thermostats. Not easy to use.
• If Control Software is Available, a Trained (Dedicated) User is Required to

Operate it

• Difficult To Find Replacement People To Run Experiments

4

Multiple Interfaces Increases Risk of Error

Solution 1: One Simple, Standard Interface

5

Integrated Control for all Equipment

• Instantly intuitive

No training required

• Single point of control for major process

parameters (dosing, temperature, stirring) No need to learn multiple interfaces

One Simple, Standard Interface

Challenge 2: Manual Parameter Control

6 Heat to 70 °C Stir at 250 rpm Dose 200 g Chiller failure

Productivity

How to avoid going back to the lab for every activity?

Safety

Behavior in case of an unexpected event? Take Sample Wait

Lack Control over Scheduling and Process Safety

Sample Method

Wait Wait Readjust parameters

Solution 2: Unattended 24/7

7

Program Sequences for Unattended 24/7 Safe Operation

• Pre-program Tasks on

Touchscreen or in iControl

• Automated parameter

control means experiments can be run overnight

• Experiments can be

quickly repeated

• Program Safety Limits
• Ensures safe unattended
• peration even with an

equipment failure

Challenge 3: Lost or Missing Data

8

• Each instrument produces different data that

may not be logged or stored

• Lack of integration makes

analysis difficult

Lost Productivity Slows the Pace of Process Optimization

Temperature pH Stirring

Solution 3: 100 % Data Capture

9

100 % Data Capture to Understand and Optimize

• Live reaction data

trended on touchscreen

• r PC
• Improve experiment

documentation and process knowledge

• Quickly repeat

experiments based on previously captured data

Example Reactor Temp Response to Dosing

• Quickly Observe Process Data as it Responds to Reaction Conditions

10 Tr (°C) Vr (mL) As Dosing Begins, Exotherm is Observed

Temperature °C Volume (mL) Time (h)

Solution 3: 100 % Data Capture

11

For Advanced Analysis Using iControl Software:

• Overlap all

reaction parameters with dosing trends and process analytical data for a full understanding of the process

Understand Reaction Kinetics to Improve Process Design

Example Detecting Temp. at Nucleation

• Link Process Temperature to ParticleTrack Data to Measure the Temperature

at the Onset of Crystallization

12

Overlap and Identify Process Conditions at Events

Temperature °C # of particles <50 microns Detect Nucleation Measure Temperature

Challenge 4: Documentation and Reporting

• Complete Documentation (Description of

Equipment and Recipe) is Difficult and Very Time Consuming Resulting in Lost or Inaccurate Information

13

No stirrer speed, temperature or set point documented (poor reproducibility) Data is not digital (information is not searchable) Captured in local language (reuse

• f knowledge limited to local team)

Poor Reproducibility and Limited Knowledge Sharing

Personal Document, not backed up or shared

Real Extract from Lab Journal

Solution 4: Powerful Reporting

• One-click MS Word/Excel

report documenting the recipe and equipment.

• Drag and drop designer

creates flexible reports with custom trend graphs

14

Generate accurate history for effective communication

Solution Overview with RX-10

15

Record complete and accurate process data for improved experiment documentation and process knowledge An integrated controller for all process chemistry equipment increases accessibility and consistency Sequences of automated parameter controls means experiments can be run safely overnight Quickly prepare reports for accurate history and effective communicaiton 100 % Data Capture One Simple, Standard Interface Powerful Reporting Unattended 24/7

Content

• Jacketed Lab Reactor (JLR) Challenges
• RX-10 Overview
• Voice of the Customer

16

RX-10 Overview

17

Existing Jacketed Lab Reactor RX-10 Base Unit

Touchscreen Operation

SmartConnect™ Sensor Port

Third party sensors such as:

• Reflux temperature
• Mass flow meter
• Pressure sensors

iControl / iC DC PC-based recipe control and data analysis with PAT integration

• Automated Dosing
• Additional sensors
• Sampling

Tr RS232

Network Accessories

Peripherals

RX-10 at a Glance

18

USB ports Data Export Firmware Upgrades SmartConnect™ sensor port Plug & play of Pt100, voltage and current sensors CAN accessories Plug & play connectivity to DU-SP50, EasySampler, ECB, etc. Ethernet (Network) iControl / iC Data Center Touchscreen port 1 m or 3 m cable length Thermostat/Stirrer RS232 port, plug & play recognition of equipment Safety relay Acoustic or visual alerts Emergency button To trigger emergency program Easy-to-use touchscreen Basic functions learned within 60 seconds

SmartConnect™ Cable

SmartConnect Cable

• Smart chip technology automatically recognizes

standard laboratory instrumentation for immediate control and data collection

No need for added adaptors or specialized setup time/cost Moving instrumentation from one vessel to another is fast and easy

• Connects to:

PT100 (Temperature) Pressure sensors, Mass Flow Meters Any Other Analog Sensor with Voltage or Current Output

RX-10: Technical Specification

20

Thermostats Huber, Julabo – all models with RS232 port. Stirrers IKA, Heidolph, J-KEM – all models with RS232 port Temperature Range Full range supported by Huber or Julabo thermostats (-120 °C – 425 °C) Volume range / Reactors Choose what is best for your application. There are no volume or reactor limits given by RX-10. SmartConnectTM Port (plug & play) Pt100 4 wires (RTD) Voltage

• 10 V to +10 V

Current 0 to 20mA Connectivity and data transfer Ethernet: Communication to PC (iControl/iC Data Center) CAN: Interface for peripherals (ECB, DU-SP50, EasySampler) USB: Data Export to USB stick Supported languages English, German, French, Spanish, Japanese, Chinese Safety features

• Emergency button for immediate execution
• f emergency program
• Emergency relay to connect audible or visual alert

Dimensions, W x D x H 70 mm x 152 mm x 215 mm (2.75” x 5.98” x 8.46”) Weight 2,88 kg, including touchscreen

RX-10: Delivery Scope

21

30208790: RX-10 with 1m touch- screen cable 30217050: RX-10 with 3m touch- screen cable 1 RX-10 main unit 1 1 2 Touchscreen 7’’ (1m cable) 1 3 Touchscreen 7’’ (3m cable) 1 4 Power Supply 1 1 5 Lab Bar Holder 1 1 6 Thermostat/Stirrer RS232 cables 1 1 7 USB memory stick 2GB 1 1 8 iControl DVD 1 1 9 iControl Office License 1 1 10 RX-10 Quick Start Guide 1 1

EasyMax 402 100 ml – 400 ml OptiMax 250 ml – 1000 ml EasyMax 102 1 ml – 400 ml

Synthesis and Process Development Tools

EasyMax and OptiMax are Turn Key Development Workstations

• All-in-one System / Minimal Footprint
• Reactors are Easy to Change and Easy to Clean
• No Need For External Thermostat
• Ready-to-Go Reactor Setups
• Fast And Stable Temperature Control
• Easily Upgrade To Calorimeter

22

Feature Comparison

23

# Feature Standalone JLR RX-10 EasyMax / OptiMax RC1e 1 All-in-one system / minimal footprint     2 Reactor easy to change/clean     3 No need for external thermostat     4 Ready to go reactor setups

for distillations, pressure, ..

    5 Touchscreen to control ALL process params     6 iControl    * 7 iC Data Center     8 PAT data integration     9 UCB Universal Control Box (RS485) – PC only     10 EasySampler integration     11 ECB Easy Control Box (CAN plug'n'play)     12 DU-SP50 Dosing Unit (syringe pump)     13 Upgradable to calorimeter     14 RTCal     15 Adiabatic mode     16 Real Tj measurement not T bath of chiller

• 

 17 Tr-Tj control for distillations / reflux     18 Non-linear ramps for crystallizations     19 Fast and stable T control     20 One-click report    

* = iControl recipe exchange possible between RX-10, EM and OM but not with RC1e. iControl for RC1e is a different application.

RX-10 Data Handling

Touchscreen Easy to use control in front of the reactor

File transfer and basic evaluation after experiment completion

Data Management Capture and archive data

Automated data capture, preparation and sharing Advanced

• nline/offline

evaluation iControl

PC Software Advanced control, may be at a remote location

iC Data Center USB / Ethernet

Touchscreen

25

Programming a T Ramp Live Trend Graph Pre-programming of Up to 6 Steps Homescreen – Learn in 60s

iControl – Powerful PC Software

• Easy-to-Use
• Advanced Task Programming
• Re-run of Experiments
• Comprehensive Trend Graph
• Intuitive Data Processing
• Powerful Reporting Function
• Seamless Integration with

METTLER TOLEDO Analytical Tools

26

iControl – One Software for all Volumes

27 EasyMax 402 100ml – 400ml OptiMax 250ml – 1000ml RX-10 >1000ml EasyMax 102 1ml – 400ml

Small Volume Medium Volume Large Volume Copy Recipes Between Reactors; Easily Overlay and Compare Data

iControl – Remote Control from PC

28

Up to 4 Connected Units – RX-10, EasyMax or OptiMax Drag'n'Drop Recipe Designer Drag'n'Drop  iControl Introduction Video on YouTube (4min)

RX-10 Laboratory: iC Data Center

Automated Data Collection with iC Data Center

• Automatically

Capture, Prepare and Share data from variety of instruments and transform it into valuable process data

• iControl is not

required – data capture without the need for a PC in the lab!

• Jacketed Lab Reactor (JLR) Challenges
• RX-10 Overview
• Voice of the Customer

Content

31

Voice of the Customer

32

Since we installed the RX-10, our jacketed lab reactors are used much more

• frequently. It is now easy and intuitive to program, manage and store data, and

interpret experimental results. Safety limits on reactors reduce risk for the whole lab… In short, RX-10 makes our jobs easier and safer.

Andy Huygaerts, Janssen Pharma, Belgium

The RX-10 is a universal Jacket Lab Reactor (JLR) control unit that works truly plug’n play. My favorite function: It enables basic lab operations such as temperature, agitation and dosing control as well as data capturing on existing

• equipment. A simple entry door into the world of lab automation!

Gregor Schock (Grünenthal, Germany)

The RX-10 unit is a versatile solution to optimize scale-up processes. In our Lab, it has closed the gap between EasyMax/OptiMax Synthesis Workstations and multi-liter JLR vessels. As main benefits, it provides a consistent lab workflow to the user and gives documentation of experiments along the whole scale-up workflow.

• Dr. Carsten Griebel (Grünenthal, Germany)

Questions?

33

100 % Data Capture One Simple, Standard Interface Powerful Reporting Unattended 24/7

http:// http://www.labtex.co.uk/product/rx-10-reactor-control-data-capture