QIAGEN 2012 Annual General Meeting June 26, 2013, Venlo, the - - PowerPoint PPT Presentation

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QIAGEN 2012 Annual General Meeting June 26, 2013, Venlo, the - - PowerPoint PPT Presentation

Sample & Assay Technologies QIAGEN 2012 Annual General Meeting June 26, 2013, Venlo, the Netherlands Peer M. Schatz, Chief Executive Officer Forward looking statements Sample & Assay Technologies Safe Harbor Statement: Certain of the


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Sample & Assay Technologies

QIAGEN 2012 Annual General Meeting

June 26, 2013, Venlo, the Netherlands

Peer M. Schatz, Chief Executive Officer

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Sample & Assay Technologies

Forward looking statements

Safe Harbor Statement: Certain of the statements contained in this presentation may be considered forward-looking statements within the meaning of Section 27A of the U.S. Securities Act of 1933, as amended, and Section 21E of the U.S. Securities Exchange Act of 1934, as amended. To the extent that any of the statements contained herein relating to QIAGEN's products, markets, strategy

  • r operating results, including without limitation its expected operating results, are forward-looking, such statements are based on

current expectations and assumptions that involve a number of uncertainties and risks. Such uncertainties and risks include, but are not limited to, risks associated with management of growth and international operations (including the effects of currency fluctuations, regulatory processes and dependence on logistics), variability of operating results and allocations between business segments, the commercial development of markets for our products in applied testing, personalized healthcare, clinical research, proteomics, women's health/HPV testing and nucleic acid-based molecular diagnostics; changing relationships with customers, suppliers and strategic partners; competition; rapid or unexpected changes in technologies; fluctuations in demand for QIAGEN's products (including fluctuations due to general economic conditions, the level and timing of customers' funding, budgets and other factors); our ability to obtain regulatory approval of our products; difficulties in successfully adapting QIAGEN's products to integrated solutions and producing such products; the ability of QIAGEN to identify and develop new products and to differentiate and protect our products from competitors' products; market acceptance of QIAGEN's new products and the integration of acquired technologies and

  • businesses. For further information, please refer to the discussions in reports that QIAGEN has filed with, or furnished to, the U.S.

Securities and Exchange Commission (SEC). Regulation G: Some of the slides in this presentation contain certain summary information about QIAGEN N.V.’s sales, gross profit,

  • perating income, net income, and earnings per share, which information is presented on a “non-GAAP financial measures” basis

rather than in accordance with U.S. generally accepted accounting principles (GAAP). Please review QIAGEN’s press releases, which can be found in the Investor Relations section of QIAGEN’s webpage under www.QIAGEN.com, for information on the Company’s operating income, net income, and earnings per share presented on a GAAP basis. Such GAAP-basis information will also be contained in the Company’s reports on Form 20-F or Form 6-K to be filed with or furnished to the U.S. Securities and Exchange Commission.

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Sample & Assay Technologies

Agenda

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  • Prof. Dr. Detlev H. Riesner

Chairman of the Supervisory Board Peer Schatz CEO Annual General Meeting

QIAGEN Annual General Meeting - June 26, 2013

QIAGEN strategy update Introduction

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Sample & Assay Technologies

Our mission, vision and strategy

Vision Future we envision A world where our Sample & Assay Technologies “Make Improvements in Life Possible” Mission Defines our purpose Market and technology leadership in enabling access to content in biological samples Strategy How to achieve vision and fulfill mission We leverage our Sample & Assay Technology leadership across customer classes

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Sample & Assay Technologies

Pharma

Making improvements in life possible

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Molecular revolution is only just beginning

How do we secure food supplies and protect public safety? Applied Testing Academia Molecular Diagnostics How do we fight diseases and improve healthcare? How do we develop better and safer drugs? How do we achieve scientific breakthroughs even faster?

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Sample & Assay Technologies

World leader in Sample & Assay Technologies

 Enable access to molecular information  > 500 core products  > 500,000 customers worldwide  Innovative power  Healthy financial position

2012 key figures (In $ millions)1

Net sales 1,254 + 10% (CER) Adjusted net income 260.7 11% Adjusted EPS (in $ per share) 1.08 Employees ~4,000

(1) US-GAAP results CER – Constant exchange rates QIAGEN Annual General Meeting - June 26, 2013

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Sample & Assay Technologies

Broad product offering with common purpose

From biological sample to highest-value interpretable result

SAMPLE Technologies ASSAY Technologies BIOLOGICAL SAMPLE VALUABLE MOLECULAR INFORMATION

Extract DNA, RNA and proteins in reliable process Make molecular info visible and available for interpretation

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Sample & Assay Technologies

Instruments

Comprehensive product range to support workflows

2012 net sales: $1.25 billion

Leading portfolio of molecular tests for use with range of instruments

Consumables

86% 14%

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Sample & Assay Technologies

2012 sales Key customers Product highlights

~49%  Reference labs  Hospitals  Prevention: HPV, QuantiFERON-TB  Profiling: Infectious diseases  Personalized Healthcare: Companion diagnostics  Point of Need: AmniSure, ESE ~8%  Forensic labs  Industrial  Governments  Human identification / forensics  Veterinary medicine  Food safety ~19%  Big Pharma  Specialty / Biotech  CROs  Gene and pathway analysis  Biomarkers ~24%  Government research  Academic labs  Life sciences research  Translational medicine

Supporting >500,000 customers worldwide

Applied Testing Pharma Academia Molecular Diagnostics

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Sample & Assay Technologies

163 200 223 234 261 50 100 150 200 250 300 2008 2009 2010 2011 2012

Adjusted net income1

Sustained sales and earnings improvement

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(1) US-GAAP results CAGR – Compound annual growth rate Net income adjusted excluding business integration and relocation related charges as well as amortization of acquired IP and equity-based compensation (SFAS 123R)

2008 – 2012 CAGR = 14%

In $ m In $ m

2008 – 2012 CAGR = 19%

Net sales

893 1,010 1,087 1,170 1,255 200 400 600 800 1,000 1,200 1,400 2008 2009 2010 2011 2012

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Sample & Assay Technologies

Full-year 2012: All customer classes deliver higher sales

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2012 sales contribution ~33%

U.S.: ~12% RoW: ~4%

~8% ~19% ~24% Change (CER) +33%

  • 8%

+22% +5% +1%

Pharma Academia Applied Testing MDx growth drivers

(RoW)

HPV

(U.S.)

Rapid growth from Molecular Diagnostics growth drivers and Applied Testing 2012 net sales: $1.25 billion (+10% CER)

RoW – Rest of world CER – Constant exchange rates

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Full year 2012: US-GAAP and IFRS results

QIAGEN N.V. Consolidated Income Statement for year ended December 31, 2012

QIAGEN Annual General Meeting - June 26, 2013

12 In $ thousands (Except per share data) IFRS 2012 US-GAAP 2012 IFRS vs. US-GAAP Net sales 1,254,456 1,254,456 Income from operations 171,174 169,814 1,360 Net income 126,222 129,537 (3,315) Earnings per share attributable to equity holders of QIAGEN N.V. (Basic and diluted) Weighted average number of common shares, basic 235,582 235,582 0% Basic in $ per share 0.54 0.55 (0.01) Weighted average number of common shares, diluted 237,923 240,746 (2,823) Diluted in $ per share 0.53 0.54 (0.01)

No material difference between US-GAAP and IFRS results

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Sample & Assay Technologies

Full year 2012: Key results (US-GAAP)

In $ millions (Except EPS) FY 2012 FY 2011 Change $ (CER) Net sales 1,254.5 1,169.7 +7% (+10% CER) Adjusted gross profit 896.9 832.5 +8% Adjusted gross profit margin 71% 71% Adjusted operating income 356.4 319.6 +12% Adjusted operating income margin 28% 27% Adjusted tax rate 21% 24% Adjusted net income 260.7 234.4 +11% Adjusted EPS 1.08 0.98 Weighted average number of diluted common shares (In millions) 240.7 239.1

CER – Constant exchange rates For further information on adjustments, please refer to the reconciliation tables in QIAGEN's Q4 2012 earnings release or appendices. Adjusted net income and adjusted EPS based on net income attributable to owners of QIAGEN N.V.

 +6% CER growth from recent acquisitions  Achieved 2012 margin goal, strong finish 13

QIAGEN Annual General Meeting - June 26, 2013

 In line with 2012 assumptions  Exceeded $1.06 target

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Sample & Assay Technologies

Driving innovation and growth in 2012

Initiatives 2012 achievements Drive platform success  Exceeded QIAsymphony placement goal  NGS initiative  HPV automation Add content  U.S. approvals / EU clearance Rotor-Gene Q PCR cycler therascreen KRAS artus Influenza therascreen BRAF  Completed U.S. submissions therascreen EGFR QuantiFERON CMV  New pharma co-development deals  >35 projects in MDx pipeline  AmniSure ROM test Broaden geographic presence  Dynamic growth in top 7 EGM Grow efficiently and effectively  New structure and leadership changes  Free up resources to reinvest

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Prevention

Molecular Diagnostics portfolio with attractive potential

QuantiFERON-TB AmniSure and ESE therascreen companion diagnostics Expanding infectious disease menu

Applied Testing Pharma Academia Molecular Diagnostics

Personalized Healthcare Point of Need Profiling Reallocating resources to growth drivers

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Sample & Assay Technologies

2008 End 2009 End 2010 End 2011 End 2012 2013

>1,000

QIAsymphony: Unparalleled features driving dissemination of molecular testing

QIAsymphony: Expanding installed base and utilization

 Well exceeded 2012 goals

>750 installed platforms

Double-digit sales growth in consumables

Expanding R&D pipeline of new assays  Strong customer demand in all geographic regions

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Molecular Diagnostics Life Sciences ~70% ~30% >550 >750

Set to exceed 1,000 installed base during 2013

QIAsymphony installed base 2012 QIAsymphony achievements QIAsymphony end-2012 placements

>350 >200

Significant untapped growth opportunities 1,200 1,000 800 600 400 200

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Sample & Assay Technologies

Other QIAGEN systems

Ongoing menu expansion

QIAGEN Annual General Meeting - June 26, 2013

17 Molecular Diagnostics Applied Testing Pharma

Adding content across customer classes and instruments

Biomarkers Pre-molecular disease testing Bioprocessing Forensics / Food safety Pathway analysis

QIAsymphony RGQ

Academia

therascreen artus Ipsogen Investigator mericon Certal therascreen artus Ipsogen therascreen artus Ipsogen QuantiFERON-TB QuantiFERON-CMV GeneGlobe GeneGlobe QuantiFERON-TB QuantiFERON-CMV

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QuantiFERON-TB: Expanding range of target customers

Latent tuberculosis (TB)1

Expanding commercial channels to target physicians, military and prisons

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1 in 3 people worldwide…

has latent TB And of those with latent TB…

1 in 10 develop active TB

Latent TB test target groups

Public health TB control Employment screening Medical staff Fire and police Community living Correctional sites Military Universities Nursing homes Immunosuppressed patients TB risk detection Clinical trials Patient selection

(1) World Health Organization

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Sample & Assay Technologies

 Single visit, results in <24 hours  Objective, high specificity: 99.2%  Not affected by BCG vaccine Tuberculin Skin Test (1890s) QuantiFERON-TB Gold (2000s)

QuantiFERON-TB: Conversion to new gold standard

 2-4 visits required  Subjective, low specificity: 65.9%  Not reliable for TB-vaccinated people

Latent TB testing: >$1 billion total addressable market potential

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Sample & Assay Technologies

All stakeholders benefit from Personalized Healthcare

Payors  Cost savings Physicians  Confidence in decisions Patients  Better medicines Pharma companies  Value creation Providers of diagnostics  New market opportunities

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Sample & Assay Technologies

Project Partner Indication Biomarkers Status

Erbitux (cetuximab) Colorectal cancer KRAS U.S. regulatory approval in July 2012 Vectibix (panitumumab) Colorectal cancer KRAS U.S. submission (PMA) in H2 2011 PF-00299804 (dacomitinib) Lung cancer (NSCLC) KRAS In development Iressa (gefitnib) AstraZeneca Lung cancer (NSCLC) EGFR CE-IVD kit in Europe and

  • ther non-U.S. markets

(afatinib) Lung cancer (NSCLC) EGFR U.S. submission (PMA) in H2 2012 Various projects Various therapeutic areas KRAS, JAK2,

  • thers

KRAS U.S. approval July 2012 Others in development Various projects Not disclosed Various In development Not disclosed Confidential Non-oncology Confidential In development

Industry-leading portfolio of co-development projects

Selected co-development projects

Covering multiple technologies: PCR, panels and NGS options

NEW 2013

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Sample & Assay Technologies

U.S. KRAS market conversion progressing well

Oncologists demanding therascreen test

~ 110,000 ~ 75,000 ~ 45,000 Expansion

  • pportunities

End-2012 QIAGEN share1 U.S. colorectal cancer patients (Eligible for KRAS testing)

Establishing therascreen brand for wave of companion diagnostics

U.S. market conversion initiatives Labs promoting therascreen test

Current KRAS testing

(1) Annualized estimate

 Leading U.S. cancer diagnostics lab  Offers network of >2,000 pathologists

Clarient Diagnostics adopts therascreen KRAS test

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Sample & Assay Technologies

Next-generation sequencing – a new technology

PCR Pyro Next-gen sequencing Number of genes <5 <100 Thousands Achieved Information Yes/No 100s of bases Millions / billions

  • f bases

Cost per read $10 $10 >$1,000 Quantitative Yes Digital Semi DNA, RNA methylation Yes Yes Yes Complexity Low Middle High

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Expanding NGS from research to routine clinical use

Academia Pharma Applied Testing Molecular Diagnostics

Customer classes

High-throughput sequencing

Workflow needs

QIAGEN aiming to drive NGS into clinical research and molecular diagnostics

Benchtop sequencing Basic research / early studies Data validation Routine testing Target market

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Sample & Assay Technologies

Preparing to launch first NGS workflows in 2013

Assay Technologies

NGS workflow

Competitive portfolio GeneGlobe capabilities Global leader in Sample Technologies Automation

  • ptions

Bioinformatics from QIAGEN and SAP Sample Technologies Data alignment / analysis NGS run Library preparation Target enrichment DNA / RNA preprocessing Primary sample to purified DNA / RNA

 Sample-to-result workflows  Flexibility and scalability  Reliable and accurate results  Using many proven QIAGEN technologies  Cost competitive

Key features QIAsymphony NGS version QIAcube version

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Challenge: Interpreting rapidly growing data output

Need for better knowledge management Rapid growth in cancer biomarker data

Sequencing data is not the end – goal to create value with actionable results

Source: Genenews

Publications per year (Thousands) 20 15 10 5 1960 1970 1980 1990 2000 2010 Publication year

Oncogene publications Cancer biomarker publications Tumor suppressor gene publications Non-coding-RNA publications

Rapid rise in sequencing data

Source: Cisco Systems, GenBank and Alliance Bernstein

1982 1987 1991 1995 1999 2003 2007 2011E 1 1,000 1,000,000 1,000,000,000 Billions of bases Equal to 1.5 billion DVDs

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Sample & Assay Technologies

Ingenuity: Leader in data analysis and interpretation

 Private U.S. company with 120 employees  2012 sales: ~$20 million  Standard for biological data interpretation  Seamless integration into QIAGEN‘s ecosystem  Synergies with GeneGlobe panels  Strong ties to QIAGEN customers  Curated biological knowledge system  Full suite of analysis tools  Scalable web-based platform

Benefits to QIAGEN Competitive advantages At a glance Key products

Global leader in applications to quickly analyze and interpret genomic data

Ingenuity Knowledge Base

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Sample & Assay Technologies

2013 goals

Accelerate organic and strategic growth Expansion through existing portfolio and targeted M&A  Growth from new MDx products  U.S. and EU submissions  QIAsymphony placements  NGS launch  EGM contribution Deliver efficiency and effectiveness Optimize resource allocation  Improvement projects Employer of choice Best talent and top teams  Attracting and retaining top talent  Strengthening QIAGEN culture Enhance customer experience Exceed customer expectations  New QIAGEN internet site  Improving customer satisfaction

2013 goals build on 2012 progress

2013 goals to accelerate innovation and growth

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Sample & Assay Technologies

Success factor: Employees

 Providing ideal working conditions  Advancing personal development  Creating a strong corporate culture

Creating a vibrant workforce Focus / Accountability / Entrepreneurial decision-making

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Selected HR programs

 Worldwide personnel planning and development program  Performance-oriented compensation  Healthy work-life balance services

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Sample & Assay Technologies

Sustainability update

QIAGEN Annual General Meeting - June 26, 2013

30 Green development: Protecting the environment, health and safety through our products ~ 200 tons of CO2 saved in 2012 ~ 350 tons of CO2 to be saved annually starting in 2014 >10% of energy at Hilden site comes from regenerative sources ~44,000 liters / day of water saved at U.S. site Economic progress: Only a company that is economically sustainable can make improvements in life possible Among the best in “personnel development” among German companies Recognized as one of Germany’s “Top Employers” 70% of 11,000 customers in survey see QIAGEN with best reputation and reliable products Corporate citizenship: It is our responsibility to provide universal and equal access to life-saving technologies 1.5 million HPV test donations, could save lives of up to 14,000 women

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Sample & Assay Technologies

Corporate governance

QIAGEN N.V.  Organized under the laws of Netherlands  Listed on NASDAQ  Listed in Prime Standard (TecDax) of Frankfurt Stock Exchange QIAGEN endorses relevant Corporate Governance Principles:  The Netherlands  NASDAQ – Corporate Governance Rules  Germany – Corporate Governance Code

Any deviations due to incompatibilities between various regulation Please see 2012 QIAGEN annual report for more information (www.QIAGEN.com)

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Commitment to highest corporate governance standards

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Sample & Assay Technologies

QIAGEN Investor Relations 2012

 Institutional conferences worldwide > 30  Visits to institutional investors > 200  Individual meetings with investors > 1,000  Visits to QIAGEN offices worldwide > 20

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*Thomson Reuters Extel Survey 2011

Targeted IR action plan focusing on international investors

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Sample & Assay Technologies

8 19 4 Buy/Outperform Neutral Underperform/Sell

QIAGEN analyst ratings

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* Ratings not older than 90 days

Analyst ratings* (As of June 2013)

International coverage by > 30 brokerages

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QIAGEN shares vs. NASDAQ Biotech index

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QIAGEN share price development – NASDAQ 2012

Jan 0% 20% 25% 35% 30% QIAGEN IXIC Feb Mar Apr May Jun Jul Aug Sep Oct Nov Dec 15% 10% 5%

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QIAGEN shares vs. TecDAX index

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QIAGEN share price development – Frankfurt Stock Exchange (XETRA) 2012

QIAGEN TECDAX Jan 0% 20% 25% 35% 30% Feb Mar Apr May Jun Jul Aug Sep Oct Nov Dec 15% 10% 5%

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QIAGEN shares in 2013

2013 year-to-date performance as of June 24

QIAGEN Annual General Meeting - June 26, 2013

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QIAGEN 2013 year-to-date share price vs. indices

QIAGEN trading volume

Source: Yahoo Inc.

Jan Feb March April May June < QIAGEN NASDAQ TECDAX

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$100 million share repurchase program completed

 Repurchased $100 million of shares

Purchases made on Frankfurt Stock Exchange and NASDAQ

5.07 million shares repurchased  Helps compensate for higher interest expenses

$400 million U.S. private debt placement  Share repurchase infrastructure established for any potential future programs

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Program overview

Maintaining strategic flexibility while improving shareholder returns

$100 million

Completed repurchase between October 2012 – March 2013

Achieved program goal

QIAGEN share repurchase program

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Proposed for first election

Transforming the Supervisory Board

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  • Prof. Dr. Detlev H. Riesner
  • Dr. Werner Brandt
  • Dr. Metin Colpan
  • Prof. Dr. Manfred Karobath
  • Ms. Elizabeth E. Tallett

Bringing new leadership talent and expertise to Supervisory Board

Standing for re-election

  • Mr. Stéphane Bancel
  • Mr. Lawrence A. Rosen

Not standing for re-election

  • Mr. Erik Hornnaess
  • Mr. Heino von Prondzynski
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Sample & Assay Technologies

Track record of growth and innovation

Robust development pipeline

Strong free cash flow World leader in Sample & Assay Technologies

Driving the dissemination of molecular testing

Early stages of the molecular biology revolution

Key considerations: Strong growth potential

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Attractive and growing markets

Building leadership in Molecular Diagnostics

Highly competitive offering in Academia, Pharma and Applied Testing Capitalizing on diverse growth opportunities

Pioneer in Personalized Healthcare

Expansion into high-growth markets

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Agenda

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  • Prof. Dr. Detlev H. Riesner

Chairman of the Supervisory Board Peer Schatz CEO Annual General Meeting

QIAGEN Annual General Meeting - June 26, 2013

QIAGEN strategy update Introduction

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Sample & Assay Technologies

QIAGEN 2012 Annual General Meeting

June 26, 2013, Venlo, the Netherlands

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Forward looking statements

Safe Harbor Statement: Certain of the statements contained in this presentation may be considered forward-looking statements within the meaning of Section 27A of the U.S. Securities Act of 1933, as amended, and Section 21E of the U.S. Securities Exchange Act of 1934, as amended. To the extent that any of the statements contained herein relating to QIAGEN's products, markets, strategy

  • r operating results, including without limitation its expected operating results, are forward-looking, such statements are based on

current expectations and assumptions that involve a number of uncertainties and risks. Such uncertainties and risks include, but are not limited to, risks associated with management of growth and international operations (including the effects of currency fluctuations, regulatory processes and dependence on logistics), variability of operating results and allocations between business segments, the commercial development of markets for our products in applied testing, personalized healthcare, clinical research, proteomics, women's health/HPV testing and nucleic acid-based molecular diagnostics; changing relationships with customers, suppliers and strategic partners; competition; rapid or unexpected changes in technologies; fluctuations in demand for QIAGEN's products (including fluctuations due to general economic conditions, the level and timing of customers' funding, budgets and other factors); our ability to obtain regulatory approval of our products; difficulties in successfully adapting QIAGEN's products to integrated solutions and producing such products; the ability of QIAGEN to identify and develop new products and to differentiate and protect our products from competitors' products; market acceptance of QIAGEN's new products and the integration of acquired technologies and

  • businesses. For further information, please refer to the discussions in reports that QIAGEN has filed with, or furnished to, the U.S.

Securities and Exchange Commission (SEC). Regulation G: Some of the slides in this presentation contain certain summary information about QIAGEN N.V.’s sales, gross profit,

  • perating income, net income, and earnings per share, which information is presented on a “non-GAAP financial measures” basis

rather than in accordance with U.S. generally accepted accounting principles (GAAP). Please review QIAGEN’s press releases, which can be found in the Investor Relations section of QIAGEN’s webpage under www.QIAGEN.com, for information on the Company’s operating income, net income, and earnings per share presented on a GAAP basis. Such GAAP-basis information will also be contained in the Company’s reports on Form 20-F or Form 6-K to be filed with or furnished to the U.S. Securities and Exchange Commission.

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Agenda

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1. Opening

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Agenda

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2. Managing Board Report for the Year ended December 31, 2012

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Financial results (US-GAAP) Strategic initiatives

Full year 2012: Overview

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2012 review

In $ millions (Except EPS)

2012 2011 Change

$ (CER)

Net sales 1,254 1,170 +7% (+10% CER) Adjusted operating income 356 320 +12% Adjusted diluted EPS 1.08 0.98 2013 perspectives  Accelerating innovation and growth

 Increase QIAsymphony placements  Advance pipeline  Launch NGS workflow  Improve efficiency and effectiveness

 Drive platform success: >750 cumulative QIAsymphony placements  Add content: Important U.S. regulatory approvals  Broaden geographic presence: Expansion in top 7 EGM  Grow efficiently: Reallocating resources to growth  Delivering faster growth  All customer classes and regions support expansion  28% adjusted operating margin

CER – Constant exchange rates

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Full year 2012: All customer classes deliver higher sales

2012 sales contribution ~33%

U.S.: ~12% RoW: ~4%

~8% ~19% ~24% Change (CER) +33%

  • 8%

+22% +5% +1%

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Pharma Academia Applied Testing MDx growth drivers

(RoW)

HPV

(U.S.)

Rapid growth from Molecular Diagnostics growth drivers and Applied Testing 2012 net sales: $1.25 billion (+10% CER)

Molecular Diagnostics Life Sciences ~49% of sales / +15% CER ~ 51% of sales / +5% CER

RoW – Rest of world CER – Constant exchange rates

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Gaining leadership in Molecular Diagnostics

QIAGEN net sales development: 2005 – 2012

QIAGEN Private Placement Investor Presentation

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$398 m $1,254 m Molecular Diagnostics Life Sciences Other Leader in Profiling

 artus assays

Leader in Prevention

HPV test Leader in Automation

 QIAsymphony

Leader in Personalized Healthcare

DxS Applied Testing Pharma Academia Life Sciences 2005 2006 2007 2008 2009 2011 2012 2010

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Investing in internal and external growth opportunities

Investing in QIAGEN R&D portfolio  R&D investments as % of sales: ~10-11%

 Consistently among the highest industry rates

Expanding product and technology portfolio  Cellestis – QuantiFERON-TB test  Ipsogen – blood cancer testing portfolio  AmniSure – complementary to HPV portfolio  Ingenuity – leader in biological data interpretation  Intelligent Biosystems – NGS technologies Expanding geographic presence  India and Taiwan Selected 2011-2013 activities

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CER – Constant exchange rates

Maximizing investments to drive innovation and growth

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Full year 2012: Geographic sales

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CER – Constant exchange rates

Asia-Pacific / Japan leads full-year 2012 global performance

34% of total net sales / +9% CER

  • Personalized Healthcare
  • Academia and Pharma
  • Northern Europe, Nordic
  • Southern Europe

Europe / Middle East / Africa Americas 46% of total net sales / +8% CER

  • QuantiFERON-TB
  • Personalized Healthcare
  • Applied Testing
  • Academia and Pharma
  • HPV (U.S. pricing, Latin America)

Rest of world represents approximately 1% of sales

19% of total net sales / +15% CER

  • Growth in all customer classes
  • China
  • Japan

 Other emerging markets Asia-Pacific / Japan

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>750 QIAsymphony platforms now placed worldwide

 Rising number of reagent

rental agreements vs. 2011 Instruments

Full year 2012: Consumables and instruments

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~14%

+11% CER

~86%

+10% CER

Growth in all customer classes and regions

New assays in Molecular Diagnostics and Applied Testing Consumables and other revenues

Q4 2012: Consumables and other revenues +4% CER (~85% of sales), instruments +7% CER (~15% of sales)

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Full year 2012: Key results (US-GAAP adjusted)

In $ millions (Except EPS) FY 2012 FY 2011 Change $ (CER) Net sales 1,254.5 1,169.7 +7% (+10% CER) Adjusted gross profit 896.9 832.5 +8% Adjusted gross profit margin 71% 71% Adjusted operating income 356.4 319.6 +12% Adjusted operating income margin 28% 27% Adjusted tax rate 21% 24% Adjusted net income 260.7 234.4 +11% Adjusted EPS 1.08 0.98 Weighted average number of diluted common shares (In millions) 240.7 239.1

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CER – Constant exchange rates For further information on adjustments, please refer to the reconciliation tables in QIAGEN's Q4 2012 earnings release or appendices. Adjusted net income and adjusted EPS based on net income attributable to owners of QIAGEN N.V.

 +6% CER growth from recent acquisitions  Achieved 2012 margin goal, strong finish  In line with 2012 assumptions  Exceeded $1.06 target

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Full year 2012: Reconciliation to US-GAAP adjusted

In $ millions (Except EPS) Net sales Gross profit Operating income Pretax income Income tax Tax rate Net income Diluted EPS(1) Reported results 1,254.5 824.0 169.8 145.2

  • 15.6

11% 129.5 0.54 Adjustments Business integration, acquisition related and restructuring costs

  • 7.9

46.6 46.5

  • 13.9

32.8 0.14 Purchased intangibles amortization 78.5 114.6 114.6

  • 38.7

75.9 0.31 Share-based compensation 2.3 25.4 25.4

  • 5.6

19.7 0.08 Other non-recurring income and expense

  • 0.4

3.2 2.8 0.01 Total adjustments 72.9 186.6 186.1

  • 55.0

131.2 0.54 Adjusted results 1,254.5 896.9 356.4 331.3

  • 70.6

21% 260.7 1.08

(1) In $ using 240.7 million diluted shares Table may have rounding differences Net income and adjusted EPS based on net income attributable to owners of QIAGEN N.V. QIAGEN Annual General Meeting - June 26, 2013

52

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Full year 2012: Balance sheet and free cash flow

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53 As of December 31 2012 2011 Group liquidity (In $ millions) 485 276 Net debt (In $ millions) 382 338 Shareholder equity ratio 66% 68% Net debt / adjusted EBITDA ratio 0.9 0.9

Leverage ratio: Net debt / EBITDA(1)

  • 0.5

0.0 0.5 1.0 1.5 2.0 2.5 3.0 3.5 2005

(1) Adjusted US-GAAP figures excluding acquisition, integration and restructuring related charges as well as share-based compensation.

Cash flow (In $ millions) 2012 2011 Net operating cash flow 245 245 Purchases of property, plant and equipment

  • 102
  • 87

Free cash flow 143 158 0.0 3.3 2.2 0.4

  • 0.1

0.9 2006 2007 2008 2009 2010 2011 2012 0.9 0.2

Healthy financial position offers strategic flexibility to support business expansion

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Strengthening balance sheet and improving returns

 $100 million program completed in March 2013

Our view: QIAGEN shares undervalued

Compensating for additional interest expense from U.S. Private Placement Share repurchase U.S. private placement  $400 million debt offering in October 2012

 First-ever offering in U.S. debt market  Advantages of historically low interest rates  High investor demand reflected in low rates

Financial flexibility to support business expansion and improve returns

$100 million share repurchase program Number of shares: 5.07 million Volume-weighted price: EUR 14.59 (Frankfurt) $20.00 (NASDAQ) $400 m U.S. private placement: Average 3.66%  $73 million 7-year term due 2019 (3.19%)  $300 million 10-year term due 2022 (3.75%)  $27 million 12-year term due 2024 (3.90%)

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QIAGEN group debt instruments

Improved financing structure

New U.S. private debt placement  $400 million signed in October 2012  3.66% weighted average interest rate  7, 10 and 12-year maturity  Investors from U.S. insurance companies Benefits  Long-term financing at very attractive rates  Diversification of investor base Repaid revolving credit facility (RCF)  $220 million loan balance in October 2012  Funds used from U.S. private debt placement

55

Convertible bond $145 m Convertible bond $300 m RCF $520 m1 ($380 m undrawn) As of December 31, 2011 As of December 31, 2012

(1) €400 million revolving credit facility at EUR-USD exchange rate of €1.00 = $1.30 (2) €38 million other lines of credit at EUR-USD exchange rate of €1.00 = $1.30

Convertible bond $145 m Convertible bond $300 m RCF $520 m1 (All undrawn) U.S. private placement $ 400 m Other lines of credit $49 m2

QIAGEN Annual General Meeting - June 26, 2013

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Current debt maturity profile

56

Notes:

(a)

Revolving Credit Facility - €0m drawn at May 31, 2013

(b)

conversion price US$12.64

(c)

final maturity in 2024 – next investor put in August 2014

(d)

conversion price US$20.00

(e)

final maturity in 2026 – next investor put in May 2017

(f)

final maturity in 2022

(g)

final maturity in 2024

(h)

2020 and beyond

QIAGEN: Maturities of current main debt instruments

amount in million

2012 2013 2014 2015 2016 2017 2018 2019 2020 Syndicated RCF € 400 1.5% convertible bond $145 3.25% convertible bond $300 3.19% USPP $73 3.75% USPP $300 3.90% USPP $27

(a) (b) (c) (d) (e) (g) (f) (h) QIAGEN Annual General Meeting - June 26, 2013

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Stock Options and Restricted Stock Units (RSUs)

Stock Options

(In thousands)

2012 Outstanding at January 1 6,527 Granted 593 Exercised (1,444) Forfeited (82) Expired (261) Outstanding at December 31 5,333 Restricted Stock Units (RSUs)

(In thousands)

2012 Outstanding at January 1 5,651 Granted 2,574 Vested (831) Forfeited (473) Outstanding at December 31 6,921

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Employees as of December 31, 2012

Americas EMEA Asia-Pacific / Japan & RoW Total 2012 Total 2011 Change Production 219 695 86 1,000 924 8% R&D 139 478 53 670 758

  • 12%

Sales 553 585 462 1,600 1,509 6% Marketing 60 168 61 289 281 3% Admin 123 240 77 440 466

  • 6%

Total 1,094 2,166 739 3,999 3,938 2%

58

QIAGEN Annual General Meeting - June 26, 2013

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Agenda

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59

3. Supervisory Board Report on the Company's Annual Accounts (the "Annual Accounts") for 2012

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Agenda

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60

  • 4. Adoption of the Annual Accounts for 2012

(voting item)

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Agenda

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61

5. Reservation and dividend policy

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Agenda

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62

6. Discharge from liability of Managing Directors for the performance of their duties during 2012 (voting item)

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Agenda

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7. Discharge from liability of Supervisory Directors for the performance of their duties during 2012 (voting item)

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Agenda

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64

  • 8. (Re-) Appointment of
  • Mr. Stéphane Bancel
  • Dr. Werner Brandt
  • Dr. Metin Colpan
  • Prof. Dr. Manfred Karobath
  • Prof. Dr. Detlev H. Riesner
  • Mr. Lawrence A. Rosen
  • Ms. Elizabeth E. Tallett

as Supervisory Directors of the Company for a term ending on the date of the Annual General Meeting in 2014 (voting items)

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Erik Hornnaess

Deputy Chairman of the Supervisory Board Supervisory Director Chairman of the Compensation Committee Member of the Audit Committee Member of the Selection and Appointment Committee

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Heino von Prondzynski

Supervisory Director Member of the Audit Committee

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Stéphane Bancel

Nominated Supervisory Director President and Founding Chief Executive Officer of Moderna Therapeutics, Inc. Formerly CEO of bioMérieux SA

(French diagnostics company, 2012 sales: EUR 1.4 billion)

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Lawrence A. Rosen

Nominated Supervisory Director Chief Financial Officer and Member of the Board of Management of Deutsche Post DHL Formerly CFO of Fresenius Medical Care AG & Co. KGaA

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Agenda

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69

  • 8. (Re-) Appointment of
  • Mr. Stéphane Bancel
  • Dr. Werner Brandt
  • Dr. Metin Colpan
  • Prof. Dr. Manfred Karobath
  • Prof. Dr. Detlev H. Riesner
  • Mr. Lawrence A. Rosen
  • Ms. Elizabeth E. Tallett

as Supervisory Directors of the Company for a term ending on the date of the Annual General Meeting in 2014 (voting items)

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Agenda

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9. Reappointment of

  • Mr. Peer M. Schatz
  • Mr. Roland Sackers

as Managing Directors of the Company for a term ending on the date of the Annual General Meeting in 2014 (voting items)

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Agenda

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  • 10. Reappointment of Ernst & Young Accountants as auditors
  • f the Company for the year ending December 31, 2013

(voting item)

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Agenda

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72

  • 11. Authorization of the Supervisory Board, until December 26,

2014

  • a. to issue a number of Common Shares and financing preference

shares and grant rights to subscribe for such shares, the aggregate par value of which shall be equal to the aggregate par value of all shares issued and outstanding in the capital of the Company as at December 31, 2012 as included in the Annual Accounts for Fiscal Year 2012, (voting item); and

  • b. to restrict or exclude the pre-emptive rights with respect to issuing

shares or granting subscription rights, the aggregate par value of such shares or subscription rights shall be up to a maximum of 20% of the aggregate par value of all shares issued and

  • utstanding in the capital of the Company as at December 31,

2012 (voting item)

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Agenda

  • 12. Authorization of the Managing Board, until December 26, 2014, to

acquire shares in the Company's own share capital (voting item)

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Agenda

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74

  • 13. Questions
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Voting results

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75

4. Adoption of the Annual Accounts for 2012 6. Discharge from liability of Managing Directors for the performance of their duties during 2012 has been adopted has been adopted

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Voting results

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7. Discharge from liability of Supervisory Directors for the performance of their duties during 2012 8. (Re-) Appointment of

  • Mr. Stéphane Bancel
  • Dr. Werner Brandt
  • Dr. Metin Colpan
  • Prof. Dr. Manfred Karobath
  • Prof. Dr. Detlev H. Riesner
  • Mr. Lawrence A. Rosen
  • Ms. Elizabeth E. Tallett

as Supervisory Directors of the Company for a term ending on the date of the Annual General Meeting in 2014 has been adopted has been adopted

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Voting results

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9. Reappointment of Mr. Peer M. Schatz and Mr. Roland Sackers as Managing Directors of the Company for a term ending on the date

  • f the Annual General Meeting in 2014
  • 10. Reappointment of Ernst & Young Accountants as

auditors of the Company for the year ending December 31, 2013 has been adopted has been adopted

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Voting results

  • 11. Authorization of the Supervisory Board, until December 26,

2014

  • a. to issue a number of Common Shares and financing preference

shares and grant rights to subscribe for such shares, the aggregate par value of which shall be equal to the aggregate par value of all shares issued and outstanding in the capital of the Company as at December 31, 2012, as included in the Annual Accounts for 2012, (voting item); and

  • b. to restrict or exclude the pre-emptive rights with respect to issuing

shares or granting subscription rights, the aggregate par value of such shares or subscription rights shall be up to a maximum of 20% of the aggregate par value of all shares issued and

  • utstanding in the capital of the Company as at December 31,

2012 (voting item) has been adopted

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Voting results

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  • 12. Authorization of the Managing Board, until December 26, 2014, to

acquire shares in the Company's own share capital has been adopted

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QIAGEN Private Investor Day

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80

We would like to invite you to the QIAGEN Private Investor Day 2013 on

September 27, 2013

at the QIAGEN headquarters in Hilden, Germany

Contact: Sandra Kauenhowen +49 2103 29 11714 E-Mail: sandra.kauenhowen@qiagen.com

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Agenda

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81

  • 14. Closing of 2012 QIAGEN Annual General Meeting

Venlo, June 26, 2013

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Thank you for your participation