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PROTEOSTASIS European network to integrate research on intracellular - - PowerPoint PPT Presentation

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PROTEOSTASIS European network to integrate research on intracellular proteolysis pathways in health and disease COST ACTION BM1307 Duration: 25 th April 2014 until 24 th April 2018 PROTEOSTASIS The need to establish a Network PROTEOSTASIS

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European network to integrate research on intracellular proteolysis pathways in health and disease

COST ACTION BM1307 Duration: 25th April 2014 until 24th April 2018

PROTEOSTASIS

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PROTEOSTASIS

The need to establish a Network

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Lysosomes Ubiquitin- likes Proteasome Neurodegeneration Ubiquitin Autophagy Transcription Structure Cancer Signalling Apoptosis Proliferation Immune

Different disciplines with common interest PROTEOSTASIS

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Lysosomes Ubiquitin- likes Proteasome Neural degeneration Ubiquitin Autophagy

Transcription

Structure Cancer Signalling Apoptosis

Proliferation Immune

Different fields of research but common questions

COST, an opportunity for integration PROTEOSTASIS

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INTEGRATION To defragment the field and increase communication. TRANSLATIONALITY To facilitate the transfer from basic to translational science. TECHNOLOGY To foster technology and knowledge in protein homeostasis. TRAINING To create and consolidate training efforts in the field.

PROTEOSTASIS Objectives

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Rosa Barrio Olivier Coux Michael Glickman Manuel S. Rodriguez Marc Piechaczyk Dimitris Xirodimas

PROTEOSTASIS Initiators and collaborators

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Participants

PROTEOSTASIS

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UK IE ES FR DK NL DE IT AT PL SE FI EL TR IL SI PT

Participant Groups: 80

Participant Countries

Participant Countries: 17 COST

PROTEOSTASIS

November 2013

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Participant Groups: 274

PROTEOSTASIS

February 2018

Participant Countries

UK IE ES FR DK NL DE IT AT PL SE FI EL TR IL SI BE NO EE HU RS IS CH CZ RO HR UA US

Participant Countries: 27 + Ukraine + USA+ Republic of Korea

KR PT

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PROTEOSTASIS Gender Distribution

All Members Management Committee

Number % Males 28 56,00 Females 22 44,00 Total 50 100 Number % Males 12 54,55 Females 10 45,45 Total 21 100

Core Group

Number % Males 176 64,23 Females 98 35,77 Total 274 100

Males Females Males Female s

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PROTEOSTASIS

Country distribution

AT BE DK EE FI FR DE GR IS HU IE IL IT NL PL PT RO RS SI ES SE CH UK USA KR

Participant Groups: 274

February 2018

Inclusiveness Target Countries

HR CZ PL PT RO RS SI TR Non-ITC

Participant Countries

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Activities

PROTEOSTASIS

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MC, WG: Virtual?

18 STSMs 13 STSMs

PROTEOSTASIS Overview of Activities

(June 2014– April 2018)

June July August September October November December January February March April May

1st MC Meet 25/04

MC, WG, W: 3rd PROTEOSTASIS PT, 2 Nov

R Matthiesen

June July August September October November December January February March April May June July August September October November December January February March April May

MC, WG, W: 2nd PROTEOST/EMBO HR, 18-22 Sept

I Dikic

W: Proteasomes FR, 6 April

D Taillandier

Spring Autumn

TS: Ub&UbL, DE, 05 Oct

K Husnjak

TS: Yeast FR, 7 Sept

S Leon

W: ZOMES IT, 14 Feb

G Serino

W: IMYA PT, 29 Sept

P Ludovico

DM: Hormon GR, 12 July

R Barrio

W: Plant ES, 27 Sept

ML Lois

W: ECDO ES, 28 Sept

C Muñoz

TS: Ub&UbL IT, 17 Sept

D Komander

TS: Redox GR, 19 Sept

N Chondrogianni

TS: Ub&UbL, IT, 06 Sept

S Polo

TS: Aging, GR, 22 Sept

N Chondrogianni

MC,WG,W: 1st PROTEOSTASIS ES, 05 Nov

R Farràs

DM: Autoph FR, 15 Sept

D Lindholm

DM: EMBO Arg, 19 Oct

MS Rodriguez

W: Neuroacan IT, 30 Oct

L De Franceschi

DM: Aging IL, 15 Feb

T Hoppe

DM:SFBBM Sète, 28 May

O Coux

end of the project

8 STSMs

June July August September October November December January February March April

MC, WG, Final: GR, 22 Feb

  • E. Skoulakis

W: N-ter DE, Ag

N. Dissmeyer

W: EMBO HR, 15 Sept

  • F. Melchior

W: Proteas. IL, 12 Feb

  • E. Gur

W: MVB PT, 16 Feb

  • H. Girao

TS: Ub IT, 22 Sept

S.Polo

TS: Proteostasis FR, Sept

  • S. Leon

2017-2018

4th W&B Plan

2014-2015

1st W&B Plan

2015-2016

2nd W&B Plan

2016-2017

3rd W&B Plan

8 STSMs

DM: Aging GR, 16 Oct

O Coux

DM: Cancer UK, 5 July

S Polo

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PROTEOSTASIS Summary Short Term Scientific Missions

Number STSMs:

47

96569 96569 96569

http://costproteostasis.eu/stsm-summary/

Carina Holmberg-Still

UA

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PROTEOSTASIS Meetings & Workshops

1st Period

Ivan Dikic L de Franceschi

Italy 30 Oct–1Nov 2014 Symposium on Neuroacanthocytosis

Rosa Farràs

1st PROTEOSTASIS Workshop, 2nd MC

2nd Period

Spain 05-07 Nov 2014 Croatia 18-22 Sept 2015 2nd PROTEOSTASIS Workshop, 3rd MC

3rd Period 4nd Period

R Matthiesen Petek Balar

3rd PROTEOSTASIS Workshop, 4th MC Portugal 2-5 Nov 2016 4th PROTEOSTASIS Workshop, 5th MC Greece 22-24 Feb 2018

M Skoulakis Paula Ludovico

Portugal Sept 2015 International Meeting on Yeast Apoptosis Proteasomes & Autophagy

Daniel Taillandier

France April 2016 Plant Proteostasis

Maria Lois

Spain Sept 2016 Euroconference on Apoptosis

Cristina Muñoz

Spain Sept 2016 Zomes IX: PCI & Ubiq

Giovanna Serino

Italy Feb 2017 Ubiquitin & SUMO Proteostasis via N-term

Nico Dissmeyer

Germany Sep 2017

Frauke Melchior

Croatia Sept 2017 Proteasome hub

Silke Meiners

Germany Feb 2018

Eyal Gur

Vesicular Biology

Henrique Girao

Portugal Feb 2018

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PROTEOSTASIS

1st Period

Ivan Dikic L de Franceschi

Italy 30 Oct–1Nov 2014 Symposium on Neuroacanthocytosis

Rosa Farràs

1st PROTEOSTASIS Workshop, 2nd MC

2nd Period

Spain 05-07 Nov 2014 Croatia 18-22 Sept 2015 2nd PROTEOSTASIS Workshop, 3rd MC

3rd Period 4nd Period

R Matthiesen Petek Balar

3rd PROTEOSTASIS Workshop, 4th MC Portugal 2-5 Nov 2016 4th PROTEOSTASIS Workshop, 5th MC Greece 22-24 Feb 2018

M Skoulakis Paula Ludovico

Portugal Sept 2015 International Meeting on Yeast Apoptosis Proteasomes & Autophagy

Daniel Taillandier

France April 2016 Plant Proteostasis

Maria Lois

Spain Sept 2016 Euroconference on Apoptosis

Cristina Muñoz

Spain Sept 2016 Zomes IX: PCI & Ubiq

Giovanna Serino

Italy Feb 2017 Ubiquitin & SUMO Proteostasis via N-term

Nico Dissmeyer

Germany Sep 2017

Frauke Melchior

Croatia Sept 2017 Proteasome hub

Silke Meiners

Germany Feb 2018

Eyal Gur

Vesicular Biology

Henrique Girao

Portugal Feb 2018 Number of Meetings Organised

14

Number of participants reimbursed:

262 *

Meetings & Workshops

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PROTEOSTASIS Dissemination Meetings

1st Period 2nd Period 4nd Period

IUBMB Meeting on Aging and Longevity Greece October 2017

Olivier Coux Simona Polo

Beatson International Cancer Conference UK July 2015 International Insect Hormone Workshop

Rosa Barrio

Greece July 2015

Thorsten Hoppe

Israel February 2015 EMBO Regulation of aging and proteostasis

Olivier Coux

France February 2015 EMBO Regulation of aging and proteostasis

Manuel S Rodriguez

Argentina October 2014 EMBO Ubiquitin & Ubiquitin-likes Nordic, Spanish & French Autophagy Networks

Dan Lindholm

France September 2014

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PROTEOSTASIS

1st Period 2nd Period 4nd Period

IUBMB Meeting on Aging and Longevity Greece October 2017

Olivier Coux Simona Polo

Beatson International Cancer Conference UK July 2015 International Insect Hormone Workshop

Rosa Barrio

Greece July 2015

Thorsten Hoppe

Israel February 2015 EMBO Regulation of aging and proteostasis

Olivier Coux

France February 2015 EMBO Regulation of aging and proteostasis

Manuel S Rodriguez

Argentina October 2014 EMBO Ubiquitin & Ubiquitin-likes Nordic, Spanish & French Autophagy Networks

Dan Lindholm

France September 2014 Number of Dissemination Meetings:

18

Number of participants to be reimbursed:

5

Dissemination Meetings

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PROTEOSTASIS

In vivo analysis of ubiquitylation and sumoylation France September 2017

Gwenael Rabut David Komander

EMBO New approaches to study Ub and UbL mod Italy September 2016 FEBS/SFRR: Redox Regulation of Metabolic Processes

Niki Chondrogianni

Greece September 2016

Sebastien Leon

France September 2015 Ubiquitylation and sumoylation in yeast

Koraljka Husnjak

Germany October 2015 Practical on ubiquitin and ubiquitin-like proteins

Niki Chondrogianni

Greece September 2014 SFRR Biochemical Basis of Healthy Ageing EMBO Ubiquitin and related modifiers

Simona Polo

Italy September 2014

1st Period 2nd Period 3rd Period 4nd Period

Ubiquitin-assisted autophagy Italy October 2017

Simona Polo

Training Schools

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PROTEOSTASIS

In vivo analysis of ubiquitylation and sumoylation France September 2017

Gwenael Rabut David Komander

EMBO New approaches to study Ub and UbL mod Italy September 2016 FEBS/SFRR: Redox Regulation of Metabolic Processes

Niki Chondrogianni

Greece September 2016

Sebastien Leon

France September 2015 Ubiquitylation and sumoylation in yeast

Koraljka Husnjak

Germany October 2015 Practical on ubiquitin and ubiquitin-like proteins

Niki Chondrogianni

Greece September 2014 SFRR Biochemical Basis of Healthy Ageing EMBO Ubiquitin and related modifiers

Simona Polo

Italy September 2014

1st Period 2nd Period 3rd Period 4nd Period

Ubiquitin-assisted autophagy Italy October 2017

Simona Polo

Number of Training Schools Organised

8

Number of People reimbursed:

86

Training Schools

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PROTEOSTASIS

MC/CG Member

MC/CG Number %

Yes 232 54,46 No 194 45,54 Total 426 100,00

Gender Number % Males 202 47,42 Females 224 52,58 Total 426 100,00

ECI

ESR Number %

Yes 165 38,73 No 261 61,27 Total 426 100,00

Gender balance

Males 47% Females 53% Yes 54% No 46% Yes 39% No 61%

Participants in Activities (426)

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PROTEOSTASIS

Countries

AT BE EEFI FR DE GR HU IS IE IL IT NL NO PT RO RS SI ES SECH TR USA

Country Number % AT 11 2,58 BE 5 1,17 HR 0,00 CZ 4 0,94 DK 1 0,23 EE 2 0,47 FI 11 2,58 FR 53 12,44 DE 53 12,44 GR 25 5,87 HU 4 0,94 IS 1 0,23 IE 5 1,17 IL 13 3,05 IT 24 5,63 NL 19 4,46 NO 4 0,94 PL 17 3,99 PT 31 7,28 RO 5 1,17 RS 3 0,70 SI 3 0,70 ES 55 12,91 SE 13 3,05 CH 10 2,35 TR 6 1,41 UA 1 0,23 UK 40 9,39 USA 7 1,64 Total 426 100,00

Participants in Activities (426)

UK

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Dissemination

PROTEOSTASIS

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PROTEOSTASIS

Rosa Farràs

http://cost-proteostasis.eu/

Dissemination: Webpage

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PROTEOSTASIS

Rosa Farràs

http://cost-proteostasis.eu/

Dissemination: Webpage

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PROTEOSTASIS

Number of videos:

22 + 1

Dissemination: Videos

Gemma Marfany Nico Dantuma

https://www.youtube.com > PROTEOSTASIS

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PROTEOSTASIS Videos: Personal Testimonies www.cost.proteostasis.eu

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“For postdocs and students, a network is an excellent asset in their career , thanks to the possibility to get funds to travel from one lab to another, and possibly to find a new lab for the next step in their career.” "What I liked most was the training school because it was very interactive, and apart from highly educational lectures, we also had practical laboratory sessions. As a PhD student, I have learnt a lot of useful techniques for my project." I absolutely recommend becoming a member of PROTEOSTASIS. Its strength is a widespread network of scientific groups with the same interests but different

  • specialisations. That makes it possible to initiate collaborations quickly and efficiently.

"I had a short-term scientific mission of one month at the laboratory of Professor Cathrine Lindon at the University of Cambridge, where I had access to cutting-edge tools."

Selected as COST Success Story:

http://www.cost.eu/media/newsroom/boost-your-research-career

PROTEOSTASIS Videos: Personal Testimonies

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PROTEOSTASIS Social Media

https://www.youtube.com > PROTEOSTASIS

Nico Dantuma

https://twitter.com/Proteostasis https://www.facebook.com > PROTEOSTASIS

Nico Dissmeyer

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Alfred L. Goldberg Ana María Cuervo Richard I. Morimoto Ray Deshaies Richard Vierstra

PROTEOSTASIS

Ivan DIkic

Webinars

Frauke Melchior

Olivier Coux

http://cost-proteostasis.eu/ blog/

Simona Polo Elah Pick Rune Matthiesen

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PROTEOSTASIS E-Newsletters

Gemma Marfany

http://cost-proteostasis.eu/blog/ 2015 2016 2017

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PROTEOSTASIS

Number ITCs 4

Rosa Barrio

Inclusive Target Countries Conference Grants

UK IE ES FR DK NL DE IT AT PL SE FI EL TR IL SI PT CZ HR EE HU RO RS

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PROTEOSTASIS Final Action Dissemination

Open Access Publication

N Dissmeyer Olivier Coux Rosa Barrio MS Rodriguez

Core Group Members

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Impact

PROTEOSTASIS

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PROTEOSTASIS Output Overview

Joint International Publications

co-authored by at least two Action participants from two different countries participating in the Action

Other Joint Publications

by members of the network

H2020 proposals

projects spinning off from Action activities and including in the proposing consortium at least three Action participants from at least three different countries participating in the Action.

Other collaborations between members of the network

including patents and exchanges of materials and samples

23 20 10 14

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PROTEOSTASIS 10. Follow-up of MoU objectives: Progress report of working groups

Selected Projects

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Future

PROTEOSTASIS

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  • The network allowed to consolidate previous collaborations and generated new ones. Especially, the

Short Term Scientific Missions enabled the mobility of researchers between laboratories and the development of joint research projects.

  • In line with the H2020 Strategy, the transfer of knowledge to industry is a key part of PROTEOSTASIS and the

exploitation of the Translational projects consolidated during the lifetime of our Action.

  • Joint EU projects already implemented and future joint applications are being prepared between the members
  • f the network, which meets the COST Programme criteria for the consolidation of collaborations and

establishment of new ones.

  • The communication tools such as the Website, mailing list and the social networks will remain

active after the end of the project.

  • Possibility of creation of an International Scientific Society addressing the protein homeostasis subjects

covered by the network Working Groups.

How will PROTEOSTASIS continue after the ending of the funding period (by April 2018)

PROTEOSTASIS Sustainability of the network

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SUMMARY

PROTEOSTASIS

PROTEOSTASIS

cost-proteostasis@googlegroups.com Networking, Knowledge, Collaborations, H2020 Joint Grant Applications Training STSMs Website Dissemination Networking Meetings Workshops Translational Think Tank

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Acknowledgements

PROTEOSTASIS

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WG1: Protein modification Sebastien Leon

  • WG2. Proteolytic system

Pascale Bomont

  • WG3. Cell signalling

Michael Clague

  • WG4. Quality control

Wiep Scheper Petek Ballar

  • WG5. Proliferation & diff

Dimitris Xirodimas

  • WG6. Diseases & biotech

Arkaitz Carracedo Isabelle Jupin Olivier Coux Christine Blattner Makis Skoulakis

PROTEOSTASIS Working Group Leaders

Henrique Girao

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Makis Skoulakis Marc Piechaczyk Carina Holmberg-Still Olivier Coux Rosa Farràs Gemma Marfany Nico Dantuma MS Rodriguez Elah Pick E Pick

Meetings STSMs Training Website Networking Dissemination

PROTEOSTASIS

M Glickman

Tasks Coordinators

Nico Dissmeyer

Webinars

O Coux S Polo R Matthiesen

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PROTEOSTASIS MC /GC Members and Activities Organisers

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PROTEOSTASIS Special Thanks!!! Emilia Moreira Grant Holder

Inga Dadeshidze Andrea Tortajada Science Officer Admin Officer Gabriela Cristea Admin Officer

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Coralia Pérez Rosa Barrio Jim Sutherland Laura Bozal Imma Giordano

http://personal.cicbiogune.es/rbarrio/

Rosa Barrio CIC bioGUNE Functional Genomics Unit, Derio (Bilbao) Spain rbarrio@cicbiogune.es

Maria Glez. Santamarta

PROTEOSTASIS Special, Special Thanks!!!

@rosabarrio1 Rosa Barrio's Lab

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Chair: Dr Rosa Barrio (CIC bioGUNE, ES) rbarrio@cicbiogune.es Vice-Chair: Dr Olivier Coux (CRBM-CNRS, FR) olivier.coux@crbm.cnrs.fr Grant Holder: Ms Emilia Moreira (CIC bioGUNE, ES) Gholder1307@innarima.com

www.cost-proteostasis.eu

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