<log 10 s> 0 1 2 2 log 10 s max 1 0 1 2 L L e B B - PowerPoint PPT Presentation

Antigen processing and presentation all genes sink node genes ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ●● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ●● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● maximum = 3 maximum = 2 2 1 <log 10 s> 0 −1 −2 2 log 10 s max 1 0 −1 −2 L L e B B t m a m i d − e n m o r n e t n i

Antigen processing and presentation (genes with data) IFNG TNF PSME3 Proteasome HSPA1A CD8A HSP90AA1 K10784... TAP1 T cell receptor TAPBP HSPA5 PDIA3 signaling pathway CANX CALR HLA−A HLA−A HLA−A HLA−A B2M B2M B2M KIR2DS2 Natural killer cell mediated cytotoxicity IFI30 LGMN CTSB HLA−DMA CTSB LGMN CD4 CD74 CD74 CD74 100509457... 100509457... K10784... T cell receptor signaling pathway RFX5... HLA−A CREB1 100509457... CIITA NFYA CD74

Antigen processing and presentation (sink nodes) IFNG TNF PSME3 Proteasome HSPA1A CD8A HSP90AA1 K10784... TAP1 T cell receptor TAPBP HSPA5 PDIA3 signaling pathway CANX CALR HLA−A HLA−A HLA−A HLA−A B2M B2M B2M KIR2DS2 Natural killer cell mediated cytotoxicity IFI30 LGMN CTSB HLA−DMA CTSB LGMN CD4 CD74 CD74 CD74 100509457... 100509457... K10784... T cell receptor signaling pathway RFX5... HLA−A CREB1 100509457... CIITA NFYA CD74

Antigen processing and presentation mBL IFNG TNF PSME3 Proteasome HSPA1A CD8A HSP90AA1 K10784... TAP1 T cell receptor TAPBP HSPA5 PDIA3 signaling pathway CANX CALR HLA−A HLA−A HLA−A HLA−A B2M B2M B2M KIR2DS2 Natural killer cell mediated cytotoxicity IFI30 LGMN CTSB HLA−DMA CTSB LGMN CD4 CD74 CD74 CD74 100509457... 100509457... K10784... T cell receptor signaling pathway RFX5... HLA−A CREB1 100509457... CIITA NFYA CD74

Antigen processing and presentation intermediate IFNG TNF PSME3 Proteasome HSPA1A CD8A HSP90AA1 K10784... TAP1 T cell receptor TAPBP HSPA5 PDIA3 signaling pathway CANX CALR HLA−A HLA−A HLA−A HLA−A B2M B2M B2M KIR2DS2 Natural killer cell mediated cytotoxicity IFI30 LGMN CTSB HLA−DMA CTSB LGMN CD4 CD74 CD74 CD74 100509457... 100509457... K10784... T cell receptor signaling pathway RFX5... HLA−A CREB1 100509457... CIITA NFYA CD74

Antigen processing and presentation non−mBL IFNG TNF PSME3 Proteasome HSPA1A CD8A HSP90AA1 K10784... TAP1 T cell receptor TAPBP HSPA5 PDIA3 signaling pathway CANX CALR HLA−A HLA−A HLA−A HLA−A B2M B2M B2M KIR2DS2 Natural killer cell mediated cytotoxicity IFI30 LGMN CTSB HLA−DMA CTSB LGMN CD4 CD74 CD74 CD74 100509457... 100509457... K10784... T cell receptor signaling pathway RFX5... HLA−A CREB1 100509457... CIITA NFYA CD74