Production of Medical Isotopes at the FRM II Research Reactor H. - - PowerPoint PPT Presentation

▶
production of medical isotopes at the
SMART_READER_LITE
LIVE PREVIEW

Production of Medical Isotopes at the FRM II Research Reactor H. - - PowerPoint PPT Presentation

Mar 04, 2023 344 likes •542 views

Forschungsneutronenquelle Heinz Maier-Leibnitz (FRMII) Technische Universitt Mnchen Production of Medical Isotopes at the FRM II Research Reactor H. Gerstenberg, A. Kastenmller, A. Draack, C. Mller IGORR 2017, Sydney IGORR 2017 -

slide-1
SLIDE 1

Technische Universität München

Production of Medical Isotopes at the FRM II Research Reactor

  • H. Gerstenberg, A. Kastenmüller, A. Draack, C. Müller

Forschungsneutronenquelle Heinz Maier-Leibnitz (FRMII)

IGORR 2017, Sydney

IGORR 2017 - Sydney

  • H. Gerstenberg et. al.
slide-2
SLIDE 2

Technische Universität München

IGORR 2017 - Sydney

  • H. Gerstenberg et. al.

FRM II: Key Parameters

  • power: 20 MW
  • cycle length: 60 d
  • 240 operational days / year

Mission of FRM II

  • basic research by n-beams

but as an add-on also

  • Si doping
  • Production of medical isotopes
  • Cancer therapy
  • Production of tracer isotopes
  • Neutron Radiography
  • Neutron tomography,
  • …
slide-3
SLIDE 3

Technische Universität München

IGORR 2017 - Sydney

  • H. Gerstenberg et. al.

Lu-177: T1/2 = 6.7 d E(ß)max = 498 keV Eγ = 208 keV (11%) Range in human tissue: 2 mm Applications: prostate cancer NED tumours FRM II

slide-4
SLIDE 4

Technische Universität München

IGORR 2017 - Sydney

  • H. Gerstenberg et. al.

Lu 176 2.59

σ 3 + 2070

Lu 175 97.41

σ 8

Yb 176 12.7

σ 3

Lu 177

6.71d

-

Yb 177 1.9 h

160.1 d -

Yb 175 4.2 d

Yb 174 31.8

σ 68

Hf 177 18.60 Hf 176 5.206

Different production routes to Lu-177 Production Undesirable side reaction Therapy

slide-5
SLIDE 5

Technische Universität München

IGORR 2017 - Sydney

  • H. Gerstenberg et. al.

177Lu/ 177Hf

SF-ICP-MS

Zhernosekov et al.; 2011 DGN Bregenz 174 175 176 177 178 179

2 4 6 8 10 12

c.a.

177 Lu

n.c.a.

177 Lu

Mass

Isotope distribution (relative scale)

Isotopic contents in Lu-177 and Lu-177 n.c.a.

slide-6
SLIDE 6

Technische Universität München

IGORR 2017 - Sydney

  • H. Gerstenberg et. al.

Isotope production (Lu-177 n.c.a.) Top view into the reactor pool

slide-7
SLIDE 7

Technische Universität München

IGORR 2017 - Sydney

  • H. Gerstenberg et. al.

Hydraulic Irradiation Facility for Isotope Production Loading / Unloading device Canning of Yb2O3 Stack of irradiation capsules

9.3E13 1.3E14 Φth (cm-2s-1)

slide-8
SLIDE 8

Technische Universität München

Idea of Peptide Receptor Radionuclide Therapy of Neuroendocrine Tumors

IGORR 2017 - Sydney

  • H. Gerstenberg et. al.
slide-9
SLIDE 9

Technische Universität München

IGORR 2017 - Sydney H. Gerstenberg et. al.

courtesy of

Ho-166 microspheres for the radioembolization of liver tumors

Production route Ho-165 (n,γ) Ho-166 Material PLLA microspheres with holmium-166 Mean diameter (m) 30 Therapeutic β-emission 1850 keV (50.0%) 1770 keV (48.7%) Half-life (h) 26.8 Patient dose (GBq) 2-12

slide-10
SLIDE 10

Technische Universität München

IGORR 2017 - Sydney H. Gerstenberg et. al.

Irradiation using the Pneumatic Rabbit System (RPA) RPA Requirements to be met:

  • High accuracy with respect to

Ho-166 target activity

  • Low heat load to microspheres
  • Low fast neutron flux density to

guarantee mechanical integrity

  • f microspheres.
slide-11
SLIDE 11

Technische Universität München

Blood source for liver:

  • 70% portal vein
  • 30% hepatic artery

Blood source for tumor:

  • 99% hepatic artery

Unique

courtesy of

slide-12
SLIDE 12

Technische Universität München

IGORR 2017 - Sydney H. Gerstenberg et. al.

Rossendorfer Forschungsreaktor (until 1989) Research Reactor DIDO, FZJülich (until 2006) Status of Mo-99/Tc-99m in Germany: Highest consumption in Europe; No present contribution to supply

slide-13
SLIDE 13

Technische Universität München

IGORR 2017 - Sydney

  • H. Gerstenberg et. al.

Challenges to be met in Mo-99 Production at FRM II

  • Simultaneous irradiation of 16 (at least 12) targets
  • Neutron flux density in target postion > 1E14 (1/cm²s)
  • Heat release from targets during irradiation: ≈400 kW
  • Loading and unloading of targets during reactor operation
  • Integration into reactor safety instrumentation
  • Evaluation of possible interference with scientific intruments
  • Development of handling tools
  • Loading of freshly irradiated targets into transport casks
  • Adaption of infrastructure (elevator, radioprotection equipment,..)
  • Staff, cost, time schedule

Licensing Procedure according to German Atomic Law

slide-14
SLIDE 14

Technische Universität München

IGORR 2017 - Sydney

  • H. Gerstenberg et. al.

Design of the Irradiation Rig

holder for up to 4 targets Top view of irradiation rig Irradiation position

slide-15
SLIDE 15

Technische Universität München

IGORR 2017 - Sydney H. Gerstenberg et. al.

nuclear heat: Pth ≈ 420 kW battery buffer of pumps: 10 min Natural convection

Design of the cooling unit

slide-16
SLIDE 16

Technische Universität München

IGORR 2017 - Sydney H. Gerstenberg et. al.

Loading and Unloading Transfer into in-pile part Targets in Irradiation position Fuel assembly

Integration of Mo-99 facility into FRM II reactor pool

slide-17
SLIDE 17

Technische Universität München

IGORR 2017 - Sydney H. Gerstenberg et. al.

Under-water test using a mock-up: Test of mechanical function: Handling of the transport unit Loading and unloading of targets Trouble shooting Test of electrical function: Sensors, motor and cable Some Data of the water tank: Height 3,5 m Water 17 m³ Weight ca. 23,2 to

Full size mockup of changing unit

slide-18
SLIDE 18

Technische Universität München

IGORR 2017 - Sydney H. Gerstenberg et. al.

LEU target irradiationIrradiation positons: 2 channels

  • Max. number of targets

2 * 8 LEU targets Average thermal flux within meat of target: 1.7 * 1014 n cm-2s-1 Anticipated Mo-99 production: 32 weeks/year

  • Max. Mo-99 activity after 156 h of irradiation (EOI): 16 700 Ci

Expected available capacity per week (6-day Ci): ~ 2 100 Ci Anticipated start of production: 2019

Summary of important parameters

slide-19
SLIDE 19

Technische Universität München

IGORR 2017 - Sydney H. Gerstenberg et. al.

Thank you !

(heiko.gerstenberg@frm2.tum.de)