Problems with metagenome annotation How much has been sequenced? - - PowerPoint PPT Presentation
Problems with metagenome annotation How much has been sequenced? Number of known sequences 100 Environmental bacterial sequencing genomes First 1,000 bacterial bacterial genome genomes Year If the database doubles every 15 months,
First bacterial genome 100 bacterial genomes 1,000 bacterial genomes Number of known sequences Year
Environmental sequencing
Classifjcation # SS Classifjcation # SS Classifjcation # SS Experimental Subsystems 498 Regulation and Cell signaling 51 Motility and Chemotaxis 11 Clustering-based subsystems 352 Virulence 49 Plant cell walls and
10 Carbohydrates 160 Stress Response 43 Phages 10 Cofactors, Vitamins, Prosthetic Groups, Pigments 123 DNA Metabolism 41 Cell Division and Cell Cycle 10 Amino Acids and Derivatives 96 Aromatic Compounds 38 Photosynthesis 9 Protein Metabolism 95 Phages 36 Metabolite damage 8 Virulence, Disease, Defense 70 Secondary Metabolism 34 Phosphorus Metabolism 7 Miscellaneous 70 Iron acquisition and metabolism 31 Potassium metabolism 4 RNA Metabolism 65 Nucleosides and Nucleotides 24 Transcriptional regulation 2 Membrane Transport 65 Sulfur Metabolism 20 Plasmids 2 Respiration 62 Dormancy and Sporulation 17 Central metabolism 2 Cell Wall and Capsule 62 Plant-prokaryote 12 Autotrophy 2 Fatty Acids, Lipids, and 60 Nitrogen Metabolism 12 Arabinose Transport 1