Predicting condition specific transcription factors for target gene. - PowerPoint PPT Presentation

Predicting condition specific transcription factors for target gene. Kaur Alasoo 19.09.2012

Stress 1 Factor 3 Factor 4 Baseline Stress 2 Factor 1 Factor 2 Factor 1 Factor 2 Target gene

�� ArrayExpress YEASTRACT database Disruptome TRAP Differential expression was Analyzed expression Predicted binding affinities of all TF1 Gene 1 Gene 3 Gene 5 Gene 9 calculated in 234 manually data from 269 yeast TFs to the target promoter TF2 TPO1 Gene 2 Gene 4 curated yeast gene ex- TF knock-out strains sequence from Tr anscription TF3 Gene 6 Gene 7 Gene 8 pression data sets from [2]. Factor A ffinity P rediction tool ArrayExpress leading to Known targets of 184 TFs [1]. (TRAP) [3]. 1464 pairwise comparisons. Gene Set Comparisons Analysis 1 2 3 1 Gene 1 Gene 6 TPO1 Differential expression rank TPO1 Gene 9 Gene 2 2 1 2 3 1 TF1 TF2 1 3 Gene 2 TPO1 Gene 6 1 TF1 TF2 TF2 TF2 2 TF10 2 4 Gene 3 Gene 2 Gene 4 2 TF2 TF3 TF1 3 TF4 3 TF3 5 Gene 4 Gene 4 Gene 5 3 TF3 TF1 TF3 4 TF5 4 TF4 p-value p-value 6 Gene 8 Gene 3 Gene 5 5 TF6 5 TF1 Gene 7 7 Gene 6 Gene 8 Rank 6 TF7 6 TF6 Gene 3 Aggregation 8 Gene 9 Gene 7 7 TF3 TF7 7 9 Gene 5 Gene 8 Gene 7 8 8 TF5 TF8 1 TF2 10 Gene 9 Gene 1 Gene 1 9 TF9 9 TF8 score 2 TF1 10 TF10 TF9 10 3 TF3 Ranked list of TFs Ranked list of TFs Ranked list of TFs wild type vs. mutant water vs. ethanol ... Final rank aggregation ��

Predicting condition specific transcription factors for target gene. - PowerPoint PPT Presentation

Predicting condition specific transcription factors for target gene. Kaur Alasoo 19.09.2012 Stress 1 Factor 3 Factor 4 Baseline Stress 2 Factor 1 Factor 2 Factor 1 Factor 2 Target gene ArrayExpress YEASTRACT database

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