Prebiotic Evolution 1 Life, error threshold & hypercycle Walter - - PowerPoint PPT Presentation

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Prebiotic Evolution 1 Life, error threshold & hypercycle Walter - - PowerPoint PPT Presentation

Prebiotic Evolution 1 Life, error threshold & hypercycle Walter de Back Collegium Budapest Institute for Advanced Study - what is life? - the chemoton: tibor ganti - error threshold: catch-22 in evolution - hypercycles: coexisting


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Prebiotic Evolution 1

Life, error threshold & hypercycle

Walter de Back

Collegium Budapest Institute for Advanced Study

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  • what is life?
  • the chemoton: tibor ganti
  • error threshold: catch-22 in evolution
  • hypercycles: coexisting replicators
  • hypercycles in space: spatial selfstructuring
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What is life?

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“What is Life today ?”

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Chemoton Tibor Ganti

boundary template metabolism

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Pathways of supersystem evolution

boundary template metabolism M B B T M T M B T INFRABIOLOGICAL SYSTEMS

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Modern life

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Prebiotic RNA world

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Complementary Base Pairing

A = U G C

“Genetic Information”

G

Nucleic Acids (DNA, RNA) Store of Biological Information

A

RNA

A G U C U C

“Replication”

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Copying

Error threshold

AGUCUGCUAGGUAGCUAGUGAUGUAGUGCGAUG

Replication

AGUCUGCUAGGUAGCUAGUGAUGUAGUGCGAGUG GGUCUGCUAGGCAGCUAGUGAUGCAGUGCGAUG AGUCUGCUAGGUAGCUAGGCAUGUAGUGCGAUG AGUCUGCCAGGUAGCUAGUGAUGUAGUUCGAUG AGUCUGCUAGGUAGCUAGUGGUAGUGCGAUG AGUCUGCUAUGUAGCUAGUGAUGUAGUGCGAUG AGUCUGCUAGGUAGCCAGUGAUGUAGUGCGAUG AGUCUGCUAGGUAGCUAGUGAUGUAGUGCGUCG AUUCUGCUAGGUACCUAGUGAUGUAGUGCGAUG AGUCUGCUAGGUAGCUCAGUGAUGUAGUGCGAUG

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Copying

Error threshold

AGUC

Replication

AGUC GGUC AGUC AGUC AGUC AGUC AGUC AGUC AUUC AGUC

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Quasi-species and error threshold

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No genome without enzymes, and no enzyme without genomes

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Cooperation of unlinked genes

the hypercycle

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Hypercyles on a surface