Prebiotic Evolution 1 Life, error threshold & hypercycle Walter - - PowerPoint PPT Presentation

Prebiotic Evolution 1

Life, error threshold & hypercycle

Walter de Back

Collegium Budapest Institute for Advanced Study

• what is life?
• the chemoton: tibor ganti
• error threshold: catch-22 in evolution
• hypercycles: coexisting replicators
• hypercycles in space: spatial selfstructuring

What is life?

“What is Life today ?”

Chemoton Tibor Ganti

boundary template metabolism

Pathways of supersystem evolution

boundary template metabolism M B B T M T M B T INFRABIOLOGICAL SYSTEMS

Modern life

Prebiotic RNA world

Complementary Base Pairing

A = U G C

“Genetic Information”

G

Nucleic Acids (DNA, RNA) Store of Biological Information

A

RNA

A G U C U C

“Replication”

Copying

Error threshold

AGUCUGCUAGGUAGCUAGUGAUGUAGUGCGAUG

Replication

AGUCUGCUAGGUAGCUAGUGAUGUAGUGCGAGUG GGUCUGCUAGGCAGCUAGUGAUGCAGUGCGAUG AGUCUGCUAGGUAGCUAGGCAUGUAGUGCGAUG AGUCUGCCAGGUAGCUAGUGAUGUAGUUCGAUG AGUCUGCUAGGUAGCUAGUGGUAGUGCGAUG AGUCUGCUAUGUAGCUAGUGAUGUAGUGCGAUG AGUCUGCUAGGUAGCCAGUGAUGUAGUGCGAUG AGUCUGCUAGGUAGCUAGUGAUGUAGUGCGUCG AUUCUGCUAGGUACCUAGUGAUGUAGUGCGAUG AGUCUGCUAGGUAGCUCAGUGAUGUAGUGCGAUG

Copying

Error threshold

AGUC

Replication

AGUC GGUC AGUC AGUC AGUC AGUC AGUC AGUC AUUC AGUC

Quasi-species and error threshold

No genome without enzymes, and no enzyme without genomes

Cooperation of unlinked genes

the hypercycle

Hypercyles on a surface