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Polyoxin D Zinc Salt
IR-4 / BPIA Western Region Biopesticides Conference
April 26, 2017, Ft. Collins, CO
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Polyoxin D Zinc Salt
Kaken Pharmaceutical Co., Ltd.
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Polyoxin D Zinc Salt IR-4 / BPIA Western Region Biopesticides - - PowerPoint PPT Presentation
Polyoxin D Zinc Salt IR-4 / BPIA Western Region Biopesticides - - PowerPoint PPT Presentation
Polyoxin D Zinc Salt IR-4 / BPIA Western Region Biopesticides Conference April 26, 2017, Ft. Collins, CO Kaken Pharmaceutical Co., Ltd. Agrochemicals & Animal Health Products Group Presented by Cynthia Smith, Conn & Smith, Inc. 1
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Polyoxin D Zinc Salt Biochemical
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- Naturally occurring (Polyoxin D)
- Nontoxic mode of action
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Polyoxin D Zinc Salt US Formulations, Markets
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Oso 5%SC (Certis; food use)
Organic use pending
PH-D WDG (Arysta; food use)
Conventional use only
Affirm WDG (Nufarm; T&O)
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Polyoxin D Zinc Salt Targeted Crops
Grapes, berries Cucurbits Fruiting vegetables Tree fruit Tree nuts
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Polyoxin D Zinc Salt Targeted Pests
Monilinia Powdery mildew Botrytis Gummy stem blight Southern blight Apple summer diseases
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Polyoxin D Zinc Salt Best Practices
Apply preventatively for best efficacy Can be applied after pathogen is present Typical 5%SC application rates
6.5 to 13 fl oz/A 0.36 to 0.72 oz ai/A
Resistance management tool Risk reduction tool IMP tool
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Polyoxin D Zinc Salt
Mammalian Toxicology
No endpoint for risk assessment No acute to chronic effects Not mutagenic, teratogenic Not oncogenic, neurotoxic No reproductive toxicity No endocrine effects Low absorption; high excretion
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Polyoxin D Zinc Salt Environmental Toxicology
Practically nontoxic to:
Honeybee, ladybugs, and more Birds, Algae Earthworms, Beneficial soil fungi
Moderately toxic to:
Fish, Daphnia
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Polyoxin D Zinc Salt
Rapid Environmental Degradation
DT50 (Days) Degradation Route 0.4 Photolysis, natural water, sterile 2.3 Photolysis, pH 7 15.9 Aerobic soil 32.5 Hydrolysis, pH 7
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Polyoxin D Zinc Salt Environmental Risk Risk = Exposure x Hazard
Low exposure
Low AI application rate Rapid environmental degradation
Low risk
Including for fish and Daphnia
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Polyoxin D Zinc Salt Non-Toxic Mode of Action
Does not kill the fungus Competitive enzyme inhibitor Interferes with fungal chitin synthesis Sensitive fungus after treatment:
Changed morphology Stop growing Not pathogenic
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Polyoxin D Zinc Salt Mode of Action
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Treated Untreated
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Polyoxin D Zinc Salt Resistance Management Tool
Unique mode of action in N. America FRAC 19 No resistance observed in over 40
years of commercial use in Asia
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Polyoxin D Zinc Salt Crop Residue Risk Reduction Tool
0-day PHI (all crops) US EPA tolerance exemption
All crops, pre- and post-harvest 40 CFR §180.1285
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Polyoxin D Zinc Salt
International MRL “Exemptions”
Canada Mexico New Zealand Taiwan Korea (pending; summer 2017) EU (pending)
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Polyoxin D Zinc Salt MRL Trade Barrier: Japan
Toxicology data submitted
Not yet reviewed
MRL “exemption” harmonization
recently requested
Under consideration
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Polyoxin D Zinc Salt (5%SC) Blueberry / Mummyberry
(KAK-2016-Blueberry-WA-Conv)
10 20 Oso (13 fl oz/A) Oso (6.5 fl oz/A) Control Incidence Mummies Incidence Flower, Leaf Strikes
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Polyoxin D Zinc Salt (5%SC)
Sweet Cherry / Brown Rot
(Oregon, 2015) (PDMR 10:STF009)
5 10 15 20
Luna Sensation Oso (6.5 fl oz/A) + Induce Untreated Control Post-harvest Fruit Brown Rot (%) Blossom Blight (%)
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Polyoxin D Zinc Salt (5%SC) Grapes / Powdery Mildew
(California, 2012) (CER-2012-069)
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* Pristine, Rally, Quintec, Elite (FRAC 7+11, 3, 13, 3)
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Polyoxin D Zinc Salt (5%SC)
Tomatoes / Powdery Mildew
(Greenhouse, Inoculated) (BCGGA-2015-03)
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Polyoxin D Zinc Salt (5%SC)
Strawberries / Botrytis Fruit Rot
(KAK-2016-Sberry-MI)
5 10 15 20 25 30 35 40
Oso (13 fl oz/A) Oso (6.5 fl oz/A) Untreated Control
Fruit Rot Incidence (%)
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Polyoxin D Zinc Salt (5%SC)
Organic Strawberries / Botrytis
(KAK-2016-Sberry-MD) (PDMR 11:SMF020)
5 10 15 20 25 Oso (13.0 fl oz/A) Oso (6.5 fl oz/A) Organic Standard* Water Control
Infected Fruit Weight
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*[Regalia + Actinovate + Silwet] rotated with [Regalia + Serenade ASO + Silwet]
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Polyoxin D Zinc Salt (5%SC)
Cucumber / Gummy Stem Blight
(BCGGA-2015-02) (Greenhouse, Inoculated)
100 200 300 400 500 600
Pristine, Nova Oso (13.7 fl oz/A) Oso (6.8 fl oz/A) Untreated Control Severity (AUDPC) Incidence (AUDPC)
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Polyoxin D Zinc Salt Organic Use Pending
National Organic Program petition
Oso 5%SC only
2019 to 2020 launch, if approved Grower support is necessary
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Questions?
Contact: Cynthia Smith Regulatory Consultant for Kaken Conn & Smith, Inc. 703-339-1117 cindy@connsmith.com
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