PHYSICS OF BIOLOGICAL SYSTEMS ph549 LECTURE 14 Life in crowded - PowerPoint PPT Presentation

Apr 04, 2024 •318 likes •594 views

PHYSICS OF BIOLOGICAL SYSTEMS ph549 LECTURE 14 Life in crowded environments Ideal vs. Real cells Rob Philips, Physical Biology of the Cell Protein Census in E. Coli Census in E. Coli Census in E. Coli The crowded Cytoskeleton Rob

PHYSICS OF BIOLOGICAL SYSTEMS – ph549 LECTURE 14 – Life in crowded environments
Ideal vs. Real cells Rob Philips, Physical Biology of the Cell
Protein Census in E. Coli
Census in E. Coli
Census in E. Coli
The crowded Cytoskeleton Rob Philips, Physical Biology of the Cell
The crowded Cytoskeleton
Diffusion and FRAP Rob Philips, Physical Biology of the Cell
Diffusion and FRAP
Diffusion in membranes Rob Philips, Physical Biology of the Cell
Diffusion in membranes
Diffusion in crowded environments
Order through disorder Rob Philips, Physical Biology of the Cell
Depletion Interaction
Depletion Interaction
Depletion Interaction
Discs near a surface (2D)
Two large spheres
Two large spheres
Helices through crowding
Why don’t all large structures in the cell aggregate? • Electrostatic interactions • Dynamic structures (cytoskeleton/vesicles) • Active processes (energy spent in preventing aggregation) • Constrained motion (due to cytoskeleton/…)
References and further reading  Physical Biology of the Cell – Rob Phillips et. al. Chapter 14  The depletion attraction: an underappreciated force driving cellular organization, Marenduzzo et. al. JCB, 175 , 681 (2006)

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