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  30. MITOCHONDRIAL MODELLING PDF Created with deskPDF PDF Writer - Trial :: http://www.docudesk.com • Reconstructed human mitochondrial metabolic network • Optimized with ATP synthesis capacity as objective function • Subjected to hypoxia

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  32. • Hypothesized that , in hypoxia, positive PDF Created with deskPDF PDF Writer - Trial :: http://www.docudesk.com selective pressure would be driven by the need to restore ATP-producing capacity toward normoxic levels. • Found that glucose transport and oxygen uptake limited ATP synthesis capacity in hypoxia, phospholipid biosynthesis loss would impede. • Thus predicted that the 25 genes encoding the glycolysis co-set would be under positive selective, and 15 phospholipid genes under negative selective pressure.

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  34. ACADM PDF Created with deskPDF PDF Writer - Trial :: http://www.docudesk.com Mitochondrial acyl-Coenzyme ACADS A dehydrogenase ACSL1 (medium chain fatty acid CDS2 metabolism) CHKB CHPT1 CPT1B CPT2 GK GK3P GPAM PISD PPA1 Pyrophosphatase PPA2 SLC25A20 Phospholipid co-set

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