Patient Advocacy in Support of Alzheimers Disease Therapeutic - - PowerPoint PPT Presentation

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Patient Advocacy in Support of Alzheimers Disease Therapeutic - - PowerPoint PPT Presentation

May 15, 2023 116 likes •322 views

Patient Advocacy in Support of Alzheimers Disease Therapeutic Research and Development Cynthia A. Bens Vice President, Public Policy February 3, 2014 Increases in Life Expectancy 100 Neanderthal 20 40 60 80 0 20 Classical Rome 28

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Patient Advocacy in Support of Alzheimer’s Disease Therapeutic Research and Development

Cynthia A. Bens Vice President, Public Policy February 3, 2014

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Increases in Life Expectancy

20 28 33 47.3 77.9 20 40 60 80 100 Neanderthal Classical Rome Medieval England U.S. (1900) Current U.S.

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YOUNG CHILDREN AND OLDER PEOPLE AS A PERCENTAGE OF GLOBAL POPULATION PROJECTED INCREASE IN GLOBAL POPULATION BETWEEN 2005 and 2030, BY AGE

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Age and Risk of Chronic Disease

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Challenges: Alzheimer’s Disease

  • Last drug successfully approved for treatment 2003
  • No treatment to modify the disease course
  • To date trials have been long and expensive
  • High risk/no reward proposition for industry

(1 success for every 34 failures)

  • Limited (but growing!) federal research investment
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Results of Recent AD Treatment Trials

Treatment Result

Bapineuzmab Negative Dimebon Negative IVIg (Gammagard) Negative Rosiglitazone Negative Semagacestat Negative Semagacestat Negative Tarenflurbil Negative Tramiprosate Negative Xaliprodan Negative

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www.agingresearch.org www.act-ad.org cbens@agingresearch.org