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Pathogen evolution
Introduction to Evolution and Scientific Inquiry
- Dr. Stephanie J. Spielman; spielman@rowan.edu
Pathogen evolution Introduction to Evolution and Scientific Inquiry - - PowerPoint PPT Presentation
Pathogen evolution Introduction to Evolution and Scientific Inquiry - - PowerPoint PPT Presentation
Pathogen evolution Introduction to Evolution and Scientific Inquiry Dr. Stephanie J. Spielman; spielman@rowan.edu Influenza Emergence of novel influenza strains Known hosts: birds (mostly "poultry") pigs whales
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Emergence of novel influenza strains
https://www.google.com/url?sa=i&url=https%3A%2F%2Fwww.nejm.org%2Fdoi%2F full%2F10.1056%2FNEJMp058281&psig=AOvVaw2rx4GX8elZp6JIZAsl8nX0&ust= 1587066054765000&source=images&cd=vfe&ved=0CA0QjhxqFwoTCNjtxPqX6-gC FQAAAAAdAAAAABAJ
Known hosts:
- birds (mostly "poultry")
- pigs
- whales
- seals
- horses
- cats
- humans
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"Evolutionary arms race" with host
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Host immune system → selection pressure on virus
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Phylogeny of flu therefore tends to look like a ladder
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The phylogeography of HIV
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Retroviruses have very high mutation rates, and more...
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INTRAhost phylogenies
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3892624/
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Inter/intra-host phylogeny
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Phylogenetic Forensics: the FL dentist…..
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Phylogenetic Forensics: the FL dentist…..
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A phylogeny of human HIV subtypes and close SIV relatives
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Dynamics of SIV: Group O/P reservoir in gorillas
https://www.pnas.org/content/112/11/E1343
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How did HIV get to the United States?
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC21 41817/
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HIV in the United States: "Patient 0"
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