SLIDE 1
Classification system based on degree
- f atrial structural remodeling/fibrosis
Participating centers USA: 6 Europe: 8 Australia: 1 - - PowerPoint PPT Presentation
Participating centers USA: 6 Europe: 8 Australia: 1 - - PowerPoint PPT Presentation
Participating centers USA: 6 Europe: 8 Australia: 1 Classification system based on degree of atrial structural remodeling/fibrosis DECAAF Results Total Enrolled n=329 poor quality useable pre-ablation MRIs pre-ablation MRIs n=57
SLIDE 2
SLIDE 3
Total Enrolled n=329 poor quality pre-ablation MRIs n=57 (17.3%) useable pre-ablation MRIs n=272 (82.7%) Lost to follow-up n=12 (4.4%) Completed follow-up n=260 (95.6%)
DECAAF Results
SLIDE 4
Model 1: Unadjusted Model 2: Adjusted for participating center Model 3: Adjusted for age, gender and participating center Model 4: Adjusted for age, gender, hypertension (HTN), congestive heart failure (CHF), mitral valve disease (MVD), diabetes (DM) and participating center Model 5: Adjusted for age, gender, HTN, CHF, MVD, DM, paroxysmal/persistent AF, LA volume, left ventricular ejection fraction and participating center.
Association of Recurrence with Fibrosis/SRM %
Multivariate analysis
SLIDE 5
Recurrence based on the Fibrosis/ SRM staging system
SLIDE 6
Residual fibrosis was quantified from the baseline MRI by subtracting ablated scar area from post ablation DE-MRI.
Post-ablation Scar Overlap of Scar + Fibrosis
− =
Residual Fibrosis PA view Pre-ablation Fibrosis
+
Scar + Fibrosis
=
Detection of residual fibrosis (fibrotic tissue not covered with ablation lesions) after ablation at follow-up
Post-ablation Scar
SLIDE 7
Recurrence based on residual fibrosis by quartiles
85.1% 74.4% 62.8% 36.4%