Nutrition Platform Overview 2019 IFSH Annual Meeting September - - PowerPoint PPT Presentation
Nutrition Platform Overview 2019 IFSH Annual Meeting September 24-25, 2018 Indika Edirisinghe, Ph.D. Britt Burton-Freeman, PhD Amandeep Sandhu, PhD Overview Provide a research platform to support scientific inquiry of food and nutrition
September 24-25, 2018
Faculty Scientists, PhD (3)
Ezhil Azari, PhD ( New Hire -Chemistry/Nutrition)- (1) Postdoctoral Fellow, PhD ( Genomics) ( Recruiting) Bio-statistician ( Consulting) Clinical Sci / Coordinators ( 4) Medical Staff ( 5) Chemistry support scientist (1) PhD students (2) MS students (2 thesis) MS students ( Special Projects 5) OPT (3) IIT Undergraduates (3) High school summer Interns (2)
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Institute for Food Safety and Health School of Applied Technology U.S. FDA CFSAN
Center for Specialty Programs Department
Science and Nutrition Center for Nutrition Research Center for Processing Innovation
National Center for Food Safety & Technology
Bio- & Analytical
Moffett Campus Clinical Nutrition Research Center IIT Campus
WHAT WHERE Human Research (Mies campus - Tower) Biochemistry (Mies and Moffett campus) Analytical Chemistry (Moffett campus) Imaging Suite (Mies campus - Tower) Cognitive function Suite (Mies campus - Tower) Cell culture (Moffett campus) Metagenomics (Moffett campus)
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Human Research: Design, Conduct, Analyze, Publish Clinical trials
Intervention – Clinical Validation studies Bioavailability and Pharmacokinetic profiling
Consumer Behavior
Dietary patterns, attitudes and behaviors.. Key terms on Labels using ingestive behavior paradigms
Mechanism of Action Cell signaling : culture and real time harvesting from humans Gut Microbes: Food –Microbes- Metabolic Health Chemical, Biological and Behavioral Signatures System characterization (structure – function)
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Support research needs of FDA/CFSAN Office of Nutrition and Food Labeling (ONFL) to understand:
with key terms used in labeling:
Completed the project/Manuscript submission
We will be learning FDA’s Perspective on the Use of the Term “Natural” in Food Labeling –Patricia Hansen, Ph.D., Deputy Director – Office of Nutrition and Food Labeling, FDA CFSAN
“MILK” Study- Dairy vs plant-based milk alternatives
A Pilot Study Investigating Consumer Perspective and Understanding of the Term “Milk”
What nutrient do you most associate with dairy milk? What nutrient do you most associate with non-dairy milk?
09/17/13
“MILK” Study- Dairy vs plant-based milk alternatives
We are Recruiting Human Volunteers – IRB approved (IIT IRB # 2019 _059
EXCELLENCE IN SCIENCE
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Industry, Academic and Government collaboration
FDA Collaboration 10% Industry Contracts ( Non-FDA) 21% Reseach Grants ( Non-FDA) 69% Other 69%
TOTAL FUNDING 2019-2.9 MILLIONS.
FDA Collaboration Industry Contracts ( Non-FDA) Reseach Grants ( Non-FDA) 2 USDA Grants 1 From HASS Avocado 1California Strawberry 2 National Raspberry
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Pipeline Projects - Industry, Academic and Government collaboration
Industry Projects ( In negotiation) : Total funding ~1 million
Two Pending decision ( Submitted Grans) - ~ 600 K
Review and Resubmission – American Pecan Council - 450 K Collaboration with FDA : Total funding ~500 K (Proposal Submitted).
Differences in function and composition of the gut microbiome linked to food additive consumption between men and women
13 Posters and Presentation at International conferences
humans to investigate the relationship between circulating L-citrulline and arginine after watermelon intake (rind, flesh and seeds) on endothelial function
Thomas W. Boileau, Britt M. Burton-Freeman. Indika Edirisinghe, Addition of Orange Pomace to 100% Orange Juice Attenuates Acute Glucose Response Compared to 100% Orange Juice but not whole Fruit in Healthy Adults
4.Amandeep Sandhu, Jiayi Fan, Di Xiao, Indika Edirisinghe, Britt Burton-Freeman. Identification of phenolic metabolites in human plasma and urine after mango consumption
Profiles in Human Biological Samples
raspberry (Rubus idaeus L.) consumption with or without fructo-oligosaccharide on metabolic indices: a single-blinded randomized, crossover clinical trial
Nine Poster presentations We have 6 posters Presenting at this meeting.
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Excellence in science - Peer Review Publications
Published :
1: Palacios OM, Maki KC, Xiao D, Wilcox ML, Dicklin MR, Kramer M, Trivedi R, Burton-Freeman B, Edirisinghe I. Effects of Consuming Almonds on Insulin Sensitivity and Other Cardiometabolic Health Markers in Adults With Prediabetes. J Am Coll Nutr. doi: 10.1080/07315724.2019.1660929 2: Huang Y, Park E, Replogle R, Boileau T, Shin JE, Burton-Freeman BM, Edirisinghe I. Enzyme-treated orange pomace alters acute glycemic response to orange juice. Nutr Diabetes. doi: 10.1038/s41387-019-0091-z. 3: Zhu L, Huang Y, Edirisinghe I, Park E, Burton-Freeman B. Using the Avocado to Test the Satiety Effects of a Fat-Fiber Combination in Place of Carbohydrate Energy in a Breakfast Meal in Overweight and Obese Men and Women: A Randomized Clinical Trial.
4: Burton-Freeman B, Brzeziński M, Park E, Sandhu A, Xiao D, Edirisinghe I. A Selective Role of Dietary Anthocyanins and Flavan-3-ols in Reducing the Risk of Type 2 Diabetes Mellitus: A Review of Recent Evidence. Nutrients. doi: 10.3390/nu11040841. 5: Xiao D, Zhu L, Edirisinghe I, Fareed J, Brailovsky Y, Burton-Freeman B. Attenuation of Postmeal Metabolic Indices with Red Raspberries in Individuals at Risk for Diabetes: A Randomized Controlled Trial. Obesity (Silver Spring). doi: 10.1002/oby.22406. 6: Park E, Edirisinghe I, Burton-Freeman B. Avocado Fruit on Postprandial Markers of Cardio-Metabolic Risk: A Randomized Controlled Dose Response Trial in Overweight and Obese Men and Women. Nutrients. doi: 10.3390/nu10091287.
Submitted : 3 manuscript Under preparation : 3 manuscript
Rock Star Students/Staff Our Ambassadors
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Self supported Program “Sustainability”
Three Faculty + Post doc./PhD/MS students/Staff Industry/ Academic / Government- collaboration Competitive Grants Peer Review Publications
$$$$$$$ Recognition Excellent: Effective: Successful: