North Carolina Central University Human Nutrition Program Xiaohe - - PowerPoint PPT Presentation

North Carolina Central University

Human Nutrition Program

Xiaohe Yang, MD, PhD Associate Professor

• n behalf of
• Dr. Deepak Kumar, PhD

Professor and Director Biomedical/Biotechnology Research Institute (BBRI)

Three Laboratories

• Dr. TinChung Leung’ Lab

– Zebra fish models for blood development and cancer

• Dr. Xiaohe Yang’s Lab

– Breast cancer prevention and therapeutics

• Dr. Deepak Kumar’s Lab

– Tumor markers and health disparity

• Addressing human nutrition and disease-related

scientific challenges with preclinical models.

Leung group: zebrafish model for natural product study - ginger root improved blood formation

TG[flk1:GFP; gata1:dsRed], 1d

Mechanistic study of ginger effect on hematopoiesis

Megakaryocyte/ platelet RBC Myeloblast Natural killer cell B-cell T-cell Myeloid progenitor Lymphoid progenitor Multipotent hematopoietic progenitor cells

Yang Group Hormonal and Dietary Modulation of Breast Cancer Risk and Prevention

5 10 15 20 25 30 35 40 45 50 55 0.0 0.2 0.4 0.6 0.8 1.0 Control BPA 50 ng/kg BPA 500 ng/kg BPA 250 ug/kg Age on weeks Percent Tumor Free

(p<0.05)

Control IUE/BPA 500 ng/kg CD24 CD49f

Control

500 ng/kg BPA

Cyclin D1 ERα p-ERα β-actin c-myc Bcl-2 Control 50 ng/kg 500 ng/kg 250 ug/kg

BPA

Kumar Group Tumor Markers and Health Disparity

Our Contribution to Local Community

• Apply for external findings
• Employment opportunities
• Training future minority scientists
• Collaborations among universities, campuses

and external institutions

Thank You!