North Carolina Central University Human Nutrition Program Xiaohe Yang, MD, PhD Associate Professor on behalf of Dr. Deepak Kumar, PhD Professor and Director Biomedical/Biotechnology Research Institute (BBRI)
Three Laboratories • Dr. TinChung Leung’ Lab – Zebra fish models for blood development and cancer • Dr. Xiaohe Yang’s Lab – Breast cancer prevention and therapeutics • Dr. Deepak Kumar’s Lab – Tumor markers and health disparity • Addressing human nutrition and disease-related scientific challenges with preclinical models.
Leung group: zebrafish model for natural product study - ginger root improved blood formation TG[flk1:GFP; gata1:dsRed], 1d Mechanistic study of ginger effect on hematopoiesis Multipotent hematopoietic progenitor cells Lymphoid Myeloid progenitor progenitor Megakaryocyte/ Myeloblast RBC T-cell B-cell Natural killer cell platelet
Yang Group Hormonal and Dietary Modulation of Breast Cancer Risk and Prevention 1.0 BPA Control 50 ng/kg 500 ng/kg 250 ug/kg 0.8 Percent Tumor Free ER α 0.6 p-ER α Control Cyclin D1 BPA 50 ng/kg 0.4 BPA 500 ng/kg (p <0.05) c-myc BPA 250 ug/kg 0.2 Bcl-2 β -actin 0.0 0 5 10 15 20 25 30 35 40 45 50 55 Age on weeks Control IUE/BPA 500 ng/kg Control CD24 500 ng/kg BPA CD49f
Kumar Group Tumor Markers and Health Disparity
Our Contribution to Local Community • Apply for external findings • Employment opportunities • Training future minority scientists • Collaborations among universities, campuses and external institutions
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