new ways of working Dr Ghada Zoubiane Medical Research Council - UK - - PowerPoint PPT Presentation

Tackling AMR – Developing new ways of working

Dr Ghada Zoubiane

Medical Research Council - UK

AMR intergovernmental workshop - November 2015

Research Councils NIHR Defra/VMD

Patients and carers

UK Government Departments OSCHR

Medical charities Parliamentarians Policy-makers Industry International Public Research community Universities NHS Learned societies

The UK: A rich network of funders and researchers

InnovateUK

UK 5 year AMR Strategy

• DH and DEFRA: 2013 -2018
• Seven key areas of action
• Improving infection prevention and control practices
• Optimising prescribing practice, stewardship
• Improving professional education, training and public

engagement

• Developing new drugs, treatments and diagnostics
• Better access to and use of surveillance data
• Better identification and prioritisation of AMR

research needs

• Strengthened international collaboration

UK spend on AMR (2007-2013)

£163m £56m £16.8m £16.6m £0.49m £21.7m

Therapeutics Diagnostics Surveillance Transmission Environment Interventions

Total funding: £275m (<1% research budget)

Underpinning Alternatives Optimisation Lead compounds

What is needed?

• Collaborative working
• Coordination of key disciplines
• Coordinating research funding – government

and other research funders including industry

• Ensuring integration with human/animal

healthcare UK AMR Funders’ Forum

AMR Funders’ Forum (AMRFF)

• Made up of representatives from the research councils,

governmental bodies and charities

• Led and managed by the MRC
• Has a common vision for AMR research and its

implementation

• Will add value to existing programmes
• Will coordinate and/or support the initiation of funding and

delivery programmes

• Will raise the profile of the AMR research base in the UK and

internationally

AMRFF current membership

• The Arts and Humanities

Research Councils (AHRC)

• The Biotechnology and Biological

Sciences Research Council (BBSRC)

• Defra, the Veterinary Medicines

Directorate

• Department for International

Development (DFID)

• The Department of Health
• Defence Science and Technology

Laboratory (Dstl)

• The Economic and Social

Research Council (ESRC)

• The Engineering and Physical

Sciences Research Council (EPSRC)

• The Food Standards Agency (FSA)
• HSC R&D Division, Public Health

Agency, Northern Ireland

• Innovate UK
• *The Medical Research Council

(MRC)

• National Institute of Health

Research (NIHR)

• The Natural Environment

Research Council (NERC)

• Public Health England
• The Science and Technology

Facilities Research Council (STFC)

• The Wellcome Trust
• The Welsh Government

UK Research Councils

• The research councils: broad remits; support AMR

across the whole of the research spectrum

Research Councils portfolio: ~£25m per year on AMR

AMR Cross-council Initiative

• Launched June 2014
• All Research Councils – led by MRC
• Bacterial resistance in the first instance
• 4 themes to tackle AMR

Steering Group

• Herman Goossens (Chair) – University of Antwerp,

Belgium

• Sharon Peacock – University of Cambridge/Bloomsbury

Institute, UK

• Duncan Maskell – University of Cambridge, UK
• Rachel McKendry – University College London, UK
• Richard Smith- London School of Hygiene and Tropical

Medicine, UK

• Elizabeth Wellington – Warwick University, UK
• David Payne – GlaxoSmithKline
• Jared Silverman – VL32 (Ex-Cubist pharmaceuticals)

Antimicrobial Resistance – a thematic approach

Understanding resistant bacteria Accelerating therapeutic and diagnostic development Understanding real world interactions Behaviour within an beyond the health care setting

Funding

• Multidisciplinary research
• Themed calls
• Mixed funding models
• Kick start with £36m
• Scalable approach
• Networking preceding final submissions
• Priority at next CSR