N E U R O N A L R H Y T H M S A F R A M E W O R K F O R U N D E - PowerPoint PPT Presentation

2 n d N E U RO M AT WO R K S H O P S TO C H A S T I C M O D E L I N G A N D S P I K E DATA A N A LY S I S N E U R O N A L R H Y T H M S A F R A M E W O R K F O R U N D E R S T A N D I N G I N T E R A C T I O N S I N T H E B R A I N Sergio Neuenschwander Instituto do Cérebro - UFRN NATAL

G A M M A S Y N C H R O N I Z A T I O N P H A S E R E L A T I O N S H I P S

H O W D O E S T H E B R A I N O R C H E S T R A T E T H E S Y M P H O N Y O F E M O T I O N S , P E R C E P T I O N S , T H O U G H T S A N D A C T I O N S T H A T C O M E T O G E T H E R E F F O R T L E S S L Y F R O M N E U R A L P R O C E S S E S A C R O S S T H E B R A I N ? — B Y S Y N C H R O N Y O V E R M U L T I P L E F R E Q U E N C Y B A N D S . F RANCISCO V ARELA N ATURE R EVIEWS , 2001

ɣ W H A T I S S P E C I A L I N G A M M A S Y N C H R O N I Z A T I O N ?

B I N D I N G B Y S Y N C H R O N I Z A T I O N T H E L O N G - B A R E X P E R I M E N T G R A Y e t a l . , N a t u r e , 1 9 8 9

B I N D I N G B Y S Y N C H R O N I Z A T I O N C O N T R O V E R S I E S K R E I T E R a n d S I N G E R , J N S 1 9 9 6 P A L A N C A e t a l . , N e u r o n 2 0 0 6

B I N D I N G B Y S Y N C H R O N I Z A T I O N C O N T R O V E R S I E S 1 1+2 1 1+2 jeb012a02 2-2 jeb012a02 2-2 80 80 Time (ms) Time (ms) 0 0 Coincidences Coincidences 0.2 0.2 0.0 0.0 -80 -80 500 ms 500 ms Time Time C A S T E L O - B R A N C O . . N E U E N S C H W A N D E R … L I M A … N E U E N S C H W A N D E R N a t u r e , 2 0 0 0 C e b C o r t e x , 2 0 1 0

S E L E C T I V E A T T E N T I O N R O L E O F G A M M A O S C I L L A T I O N S In V4 cells activated by the attended stimulus show increased gamma-frequency (35 to 90 hertz) synchronization compared with neurons activated by distracters. F R I E S E T A L . , S C I E N C E 2 0 0 1

S E L E C T I V E A T T E N T I O N R O L E O F G A M M A O S C I L L A T I O N S Selective coherence implies into selective communication. F R I E S , N E U R O N 2 0 1 5

S T I M U L U S E N C O D I N G W I T H G A M M A P H A S E C O D I N G In V1, orientation is encoded by phase relationships between spike and LFP signals. m o d i f i e d f r o m W O M E L S D O R F , V I N C K , L I M A , . . N E U E N S C H W A N D E R , F R I E S P N A S , 2 0 1 2

B I N D I N G B Y S Y N C H R O N I Z A T I O N C O N T R O V E R S I E S T I C S , 2 0 1 5

D O G A M M A O S C I L L A T I O N S P L A Y A R O L E I N V I S I O N ?

A R T I F I C I A L v s . N A T U R A L F I X E D G A Z E S E E I N G

B E T A R E S P O N S E S C A P U C H I N M O N K E Y 20 Hz 2 5 0 m s S A C C A D E - O N S E T F I X A T I O N - O N S E T I T O , M A L D O N A D O , S I N G E R , G R Ü N C e r e b r a l C o r t e x . , 2 0 1 3

G A M M A R E S P O N S E S M A C A Q U E M O N K E Y B R U N E T … F R I E S C e r e b r a l C o r t e x . , 2 0 1 3

G A M M A R E S P O N S E S M A C A Q U E M O N K E Y B R U N E T … F R I E S C e r e b r a l C o r t e x . , 2 0 1 3

G A M M A R E S P O N S E S M A C A Q U E M O N K E Y B R U N E T … F R I E S C e r e b r a l C o r t e x . , 2 0 1 3

G A M M A O F L F P S T I M U L U S D I R E C T I O N O F M O V E M E N T 1-1 254 2-2 219 3-3 154 2° Gamma modulation depends strongly on stimulus properties, such as orientation.

R E C O R D I N G S F R O M C A P U C H I N V 1 Center Periphery

C E N T E R v s . P E R I P H E R Y G A M M A F R E Q U E N C Y D E P E N D S O N S P E E D 1° 17° juj013a01 juj011a03 Rate Rate 0.75 °/s 180 160 0.5 °/s 120 sp/s 1.25 °/s 1.0 °/s 70 sp/s 1.5 °/s 1.75 °/s 2.0 °/s Freq Freq 2.25 °/s 2.5 °/s 90 3.0 °/s 2.75 °/s 65 Hz 55 3.5 °/s 45 Hz juj011a04 3.25 °/s 2.0 2.0 0.7 3.2 0.5 3.5 juj013b03 - 04 Speed (°/s) Speed (°/s) Gamma oscillation frequency is much high for central representation.

C E N T E R v s . P E R I P H E R Y M A C A Q U E M O N K E Y 2° 2° A nic077a03..04 1-1 3-3 40 40 Power (z-score) LFP 0 0 25 50 75 100 25 50 75 100 Frequency (Hz) B Peak freqency (Hz) 90 90 N= 129 N= 129 80 80 70 70 60 60 50 50 40 40 3° 3° 10° 10° Eccentricity Does gamma oscillation frequency depends on visual map? L I M A , C H E N , S I N G E R , N E U E N S C H W A N D E R C E R E B R A L C O R T E X , 2 0 1 0

Stimulus size RF 25° 1° FP 20° juj012a01 25 pixels 1° Direction 112.5° Spatial frequency 1.5 cycles/ ° Speed 2°/ s

G A M M A D E P E N D S O N S I Z E Size MUA responses Power of LFP Rate 325 1° 30 95 sp/s 50 Gamma 75 0.50 100 0.07 150 Freq 200 58 Hz 300 400 20° 48 Hz 500 100 30 500 250 ms juj012a05 Size (pixels) 45 Hz Gamma modulation increases dramatically with stimulus size. Frequency decreases.

F I X A T I O N E P O C H T R I A L 1

F R E E - V I E W I N G E P O C H T R I A L 1

F I X A T I O N E P O C H G R A T I N G S T R I A L N

F R E E - V I E W I N G E P O C H G R A T I N G S T R I A L N

G R E A T R E S P O N S E S T O G R A T I N G S L F P G A M M A I N C A P U C H I N V 1 F I X A T I O N F R E E - V I E W I N G

F R O x C O R T I C A L G A M M A O S C I L L A T I O N F R E Q U E N C Y D E C R E A S E 1° FIXATION FREE-VIEWING 77 Hz juj013b08 Direction 225° Speed 2°/ s

N A T U R A L S C E N E S O P T I M A L D I R E C T I O N 1° FIXATION FREE-VIEWING juj013b08 Direction 225° Speed 2°/ s

V I S L A B I N S T I T U T O D O C É R E B R O - U F R N N A T A L K A T I A - S I M O N E R O C H A ( M E S T R A D O ) L U A N A D A N T A S ( M E S T R A D O ) R A F A E L A F A U S T I N O ( D O U T O R A D O ) S E R G I O N E U E N S C H W A N D E R S P E C I A L T H A N K S T O U F R N - C A P E S - C N P q