Motivation: disease progression modelling Covariate-GPLVM - - PowerPoint PPT Presentation

motivation disease progression modelling covariate gplvm
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Motivation: disease progression modelling Covariate-GPLVM - - PowerPoint PPT Presentation

Motivation: disease progression modelling Covariate-GPLVM Motivation: disease progression modelling Covariate-GPLVM Feature-level decomposition Feature-level decomposition Motivation: disease progression modelling Covariate-GPLVM Decomposing


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Motivation: disease progression modelling Motivation: disease progression modelling Motivation: disease progression modelling

GPLVM maps latent to observed data using GP mappings

Covariate-GPLVM

zi ∼ N (0, 1) Y y(j)

i

= f (j)(zi) + εij

GPLVM maps latent to observed data using GP mappings Covariate-GPLVM extends GPLVM by:

  • 1. Incorporating covariates

Covariate-GPLVM

zi ∼ N (0, 1) Y y(j)

i

= f (j)(zi) + εij x y(j)

i

= f (j)(xi, zi) + εij

GPLVM maps latent to observed data using GP mappings Covariate-GPLVM extends GPLVM by:

  • 1. Incorporating covariates
  • 2. Providing a feature-level decomposition

Covariate-GPLVM

zi ∼ N (0, 1) Y y(j)

i

= f (j)(zi) + εij x y(j)

i

= f (j)(xi, zi) + εij y

(j) i

= μ(j) + f (j)

z (z) + f (j) x (x) + f (j) zx (z, x) + εij

Feature-level decomposition

Readily available for linear models, otherwise challenging:

y(j)

i

= μ(j) + f (j)

z (z) + f (j) x (x) + f (j) zx (z, x) + εij

Feature-level decomposition

Readily available for linear models, otherwise challenging: Naive decompositions (with standard GP priors) can lead to misleading conclusions With appropriate functional constraints we learn an identifiable non-linear decomposition

y(j)

i

= μ(j) + f (j)

z (z) + f (j) x (x) + f (j) zx (z, x) + εij

Decomposing feature-level variation with Decomposing feature-level variation with Covariate Gaussian Process Latent Variable Models Covariate Gaussian Process Latent Variable Models

@kasparmartens @kasparmartens kasparmartens.rbind.io kasparmartens.rbind.io Poster #261 Poster #261

Decomposing feature-level variation with Decomposing feature-level variation with Covariate Gaussian Process Latent Variable Models Covariate Gaussian Process Latent Variable Models

Kaspar Märtens, Kieran Campbell, Christopher Yau Kaspar Märtens, Kieran Campbell, Christopher Yau @kasparmartens @kasparmartens kasparmartens.rbind.io kasparmartens.rbind.io

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Motivation: disease progression modelling

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Motivation: disease progression modelling

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Motivation: disease progression modelling

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GPLVM maps latent to observed data using GP mappings

Covariate-GPLVM

zi ∼ N (0, 1) Y y(j)

i

= f (j)(zi) + εij

slide-6
SLIDE 6

GPLVM maps latent to observed data using GP mappings Covariate-GPLVM extends GPLVM by:

  • 1. Incorporating covariates

Covariate-GPLVM

zi ∼ N (0, 1) Y y(j)

i

= f (j)(zi) + εij x y(j)

i

= f (j)(xi, zi) + εij

slide-7
SLIDE 7

GPLVM maps latent to observed data using GP mappings Covariate-GPLVM extends GPLVM by:

  • 1. Incorporating covariates
  • 2. Providing a feature-level decomposition

Covariate-GPLVM

zi ∼ N (0, 1) Y y(j)

i

= f (j)(zi) + εij x y(j)

i

= f (j)(xi, zi) + εij y

(j) i

= μ(j) + f (j)

z (z) + f (j) x (x) + f (j) zx (z, x) + εij

slide-8
SLIDE 8

Feature-level decomposition

Readily available for linear models, otherwise challenging:

y(j)

i

= μ(j) + f (j)

z (z) + f (j) x (x) + f (j) zx (z, x) + εij

slide-9
SLIDE 9

Feature-level decomposition

Readily available for linear models, otherwise challenging: Naive decompositions (with standard GP priors) can lead to misleading conclusions With appropriate functional constraints we learn an identifiable non-linear decomposition

y(j)

i

= μ(j) + f (j)

z (z) + f (j) x (x) + f (j) zx (z, x) + εij

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SLIDE 10

Decomposing feature-level variation with Decomposing feature-level variation with Covariate Gaussian Process Latent Variable Models Covariate Gaussian Process Latent Variable Models

@kasparmartens @kasparmartens kasparmartens.rbind.io kasparmartens.rbind.io

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Poster #261 Poster #261