Midlife Issues Aging Personal Work Parents/ related Health Teenage - - PDF document

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Midlife Issues Aging Personal Work Parents/ related Health Teenage - - PDF document

9/27/2018 Midlife Issues Aging Personal Work Parents/ related Health Teenage Pressures Factors Children Menopausal Richa Sood, MD MS FACP NCMP Symptoms Stress Mindfulness Amplification of Menopausal A Stress Management Strategy Symptoms


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9/27/2018 1

Richa Sood, MD MS FACP NCMP

Work‐ related Pressures

Midlife Issues

Stress

Personal Health Factors

Aging Parents/ Teenage Children Menopausal Symptoms

High Stress

Amplification

  • f Menopausal

Symptoms Decreased Productivity Interference with Work and Relationships

De Novo Mood Problems Worsening of preexisting mood problems

Overall Decreased Satisfaction with Life

Mindfulness

A Stress Management Strategy

Mindfulness is paying attention

On purpose In the present moment Non judgmentally

Mechanism of action

Possibly by avoiding emotional reactivity; And by avoiding maladaptive ruminative thinking

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9/27/2018 2

Current Study

Impact of Mindfulness and Perceived Stress on Menopausal Symptoms

Mindfulness (MF)

Perceived Stress (PS)

Menopausal Symptoms (MPS)

Design

*Cross‐sectional study of 1744 women; 40‐65 years; Tertiary care setting *Three scales used: Menopause Rating Scale (MRS); Perceived Stress Scale‐4 (PSS‐ 4) and Mindfulness Attention Awareness Scale (MAAS) *Statistical analysis: Mean(SD) for continuous variables; Frequency(%); for categorical variables; Linear regression (uni‐ and multivariate); 2‐sided tests; p<.05

  • MRS
  • 11‐item scale
  • Psychological,

somato‐ vegetative and Urogenital domains;

  • Score range 0‐

44

  • PSS‐4
  • 4‐item scale
  • Global

measure of stress over the last 4 weeks

  • Score range 0‐

16

  • MAAS
  • 15‐item scale
  • Measures

frequency of mindful states in day‐to‐day life

  • Higher mean

score implies more mindfulness

Results

2939 Women seen in the Women’s Health Clinic (Jan 2015‐Dec 2016) 709 excluded because of age

200 excluded due to lack

  • f research

authorization

286 excluded due to incomplete information

1744 women included in the study

Patient demographics

Age, mean (SD) 53.4 (6.1) BMI, mean (SD) 26.8 (6.0) Race 93% white Marital Status 82.7% married Education Status 64.6% educated at 4 year college or beyond Employment Status 65.3% employed

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Summary Statistics

MAAS, PSS‐4, and MRS

Mean SD Range

MAAS 4.4 0.9 1.0‐6.0 PSS‐4 5.1 3.5 0.0‐16.0 MRS (total) 13.9 7.5 0.0‐44.0 MRS (Psych) 4.5 3.7 0.0‐16.0 MRS (Som‐Veg) 5.3 3.0 0.0‐16.0 MRP (Urogen) 4.1 2.8 0.0‐12.0

Results Multivariable Linear Regression

MAAS and PSS‐4 on MRS

Variable Estimate (95% CI) P value

MRS Total

PSS‐4 0.84 (0.46, 1.21) <.001 MAAS ‐1.16 (‐1.75, ‐0.56) <.001 PSS‐4*MAAS ‐0.09 (‐0.18, ‐0.01) .03

MRS Psychological

PSS‐4 0.58 (0.42, 0.74) <.001 MAAS ‐0.48 (‐0.73, ‐0.23) <.001 PSS‐4*MAAS ‐0.06 (‐0.09, ‐0.02) .001

MRS Urogenital

PSS‐4 MAAS 0.09 (0.03, 0.14) ‐0.49 (‐0.67, ‐0.31) 0.002 <0.001

MRS Somato‐vegetative

PSS‐4 MAAS 0.02 (0.03, 0.08) ‐0.39 (‐0.56, ‐0.20) 0.44 <0.001

Impact of MAAS on MRS with changing PSS‐4 values

PSS‐4 Value Change in MRS (Total) for 1‐point increase in MAAS total score ‐1.16 4 ‐1.53 8 ‐1.90 12 ‐2.27 16 ‐2.64

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Discussion

What we found:

In this cross‐sectional study, mindfulness was associated with lower menopausal symptom burden. In women with higher stress, the magnitude of association between mindfulness and menopausal symptoms appeared more robust.

What is already known:

*Mindfulness is linked to positive mental health outcomes and health behaviors, better quality of life, improved insomnia, and better self care in non‐menopausal settings. *In the menopausal setting, mindfulness based stress reduction (MBSR ) was shown to reduce menopausal symptom bother from 21.6% to 10.5% in 110 peri‐ and postmenopausal women. MBSR participants had significant improvements in QOL, sleep, anxiety and stress (p<.05).

What is new in this study:

*This study cohort was not trained in mindfulness. *Thus, trait (or dispositional mindfulness) appears to be protective against stress and symptoms in midlife women.

Discussion

What is the possible mechanism of action:

  • 1. Mindfulness allows for attention training.

Since ‘trained’ attention can be deployed at will, more mindful women may be choosing to shift their attention to more pleasant aspects of life rather than their symptoms

  • 2. Mindfulness allows for avoiding emotional reactivity and ruminative thinking

More mindful women may be softening the impact of their symptoms by avoiding negative emotional response to their symptoms, and by decreasing ruminations about their implications.

If you allow me to speculate a bit…

  • 1. In our study, the association of higher mindfulness and lower menopausal

symptoms was most robust in the psychological domain. What is the possible explanation? *The underpinnings of psychological symptoms rest in threat focused attention and emotional reactivity. So the mindfulness approach appears to fit very well to impact such a change. *In the somato‐vegetative and urogenital domains, those women with higher emotional reactivity (or perceived stress) may have reaped greater benefit with mindfulness compared to those with less reactivity.

  • 2. Total menopausal symptom experience (B) = Physical symptoms (A) + emotional

response to symptoms Mindfulness might be a tool to impact the emotional component of the overall experience, thereby decreasing the total suffering (burden)

Discussion

What are the limitations of this study:

  • Tertiary care setting
  • Homogenous population
  • Cross‐sectional design

What are the conclusions:

  • Higher mindfulness in midlife women appears to impact

women’s stress and menopausal symptoms positively.

  • The current study adds to the wealth of data supporting the

role of mindfulness in various settings for impacting positive change in health and behaviors.

  • There is a need to do more research with heterogeneous

sample of women using causal study designs.

Thanks for your attention! sood.richa@mayo.edu