Matrix and Matrix Detoxification Dr. Stefan Kuprowsky, MA, ND - - PDF document

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Matrix and Matrix Detoxification

• Dr. Stefan Kuprowsky, MA, ND

Evolutionary Biology of the Matrix

• Single cell organisms have a

direct contact with their external environment

• Multi-cellular organisms have a

cell protective area between the external environment and their cells

• This protective area is an

extracellular space and is now called the extracellular matrix. It is the filter between the cell and the external environment

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Original Concept of the Matrix New Concept

• f the Matrix

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Extra Cellular Matrix or Matrix

• The matrix is a 3-dimensional

fine-structured biophysical filter that controls the transmission of cell nutrition and waste products, mediators

• Any substance from the cell or

external environment must pass through this matrix

ECM: 3 Classes of Molecules

• Structural Proteins: Collagen

and Elastins

• Gel proteins: ProteoGlycans
• Adhesive Glycoproteins:

Fibronectins and Laminins

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Functions of the Matrix Collagen

• Makes up 30 % of total

body protein content

• Secreted by

Fibroblasts

• Triple Helix Structure

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Collagen has a Crystal Structure Collagen- Water Complex

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Proteoglycans

Organize water molecules Forms space between cells and collagen Gel- increases viscosity Cell anchoring, migration and adhesion Links with collagen to form a network Fine structure of the GAGs at the end of a PG creates a narrow 3-D web that functions as a biophysical filter

Collagen - Proteoglycans

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Intercellular or Interstitial Fluid

Consists of a water carrier containing fatty acids, sugars, coenzymes, hormones, neuropeptides, salts, minerals, and wastes Indispensable medium that makes it possible to maintain homeostasis between the intra and extracellular zones Nutrition Waste disposal Communication

Histology of the ECM

Middle of the picture = cell surrounded by BM and to the right a network of PGs and GAGs Under E is the rough structure of collagen fibres and web structure

• f the PGs and GAGs

Insert = fine mesh structure of PGs and GAGs

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Extracellular Matrix Extracellular Matrix: a Functional Unit

• Capillary  Connective Tissue  Cell Membrane
• ECM is bathed in the Extracellular Fluid
• Connected to the endocrine system via capillaries
• Connected to the CNS by peripheral nerves and

neuropeptides

• Communication system of the body through

prostaglandins, cytokines, lymphokines, neuropeptides, proteases: all producing an interactive feedback system with the entire body

• Forms the basis for the Mind-Body Connection

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Matrix Energetics

• Collagen is a hydrated semi-

conductor

• Electrons are semi conducted

through the helical protein

• Protons (H+) and Hydroxyls

(OH-) migrate through the hydration shell

• Charge transfers are vital to

life

• Electrons from the matrix can

neutralize free radicals

Matrix has Electric Properties

• Hydrated liquid crystals
• Semiconductor
• Piezoelectric
• Pyroelectric
• Thermoelectric
• Electrets

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Cell Communication = Cell Regulation Historical Development of Matrix Physiology

• Claude Bernard
• Wilhem Schuessler
• Alfred Pischinger
• Harmut Heine
• Mae-Wan Ho
• James Oschman

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Claude Bernard

1813-1878 Father of experimental physiology in France Discovered the function

• f the Pancreas,

glycogenic function of the Liver and the Vasomotor System Developed the term “ Le milieu interieur”........... the interior terrain/ environment The cell is influenced by it direct environment Only in dysfunction of homeostasis , diseases appear

Wilhem Schuessler

1821 – 1898

The connective tissue is: “the matrix where the most secret currents pass “

1874 “An Abridged Therapy based on Physiology and Cellular Pathology” Influenced by Virchow to develop a homeopathic based therapy Biochemic Therapy: “restoration of the body and thereby the cell, will result from restoration of the deficit of the inorganic salts”

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Alfred Pischenger

1899 - 1983 Head of Anatomical Institute at the University

• f Vienna

Developed concept of the Ground Substance

• r Matrix and the

Ground Regulation System or GRS Described it as a amorphous gel-like substance filling the whole extracellular environment

Morpho-Functional Unit = Matrix

• Capillary
• Matrix
• Membrane
• The Matrix is the

Basic Regulation System

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A Pischinger

1975 Matrix and Matrix Regulation: Basis for a Holistic Theory of Medicine

Pischenger:

The Base of the Iceberg

“ ...to understand the leading role of the function of the ground system in the pathogenesis of chronic disease and degenerative diseases, it has to be emphasized that the ground system is not only the starter for information at cells, the humoral system and the nervous system, but that the function of the system itself can be altered by every functional disturbance of the tissues “

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Ground System or ECM

• System of Homeostasis: the capacity of an
• rganism to regulate its internal

environment

• 20 % of the body mass
• Electric potential set point : 240 uV which

is reactive to changes in ph, stress, inflammation, toxins etc.

• Field of most regulatory processes in the

body

• Self-regeneration occurs through

Fibroblasts

• Battlefield of the non-specific defence

system of the immune system

• Direct environment of the cell
• Self-renewing every 120 days if physiology

is balanced

Harmut Heine

• b. 1941

Histologist Defined the Acupuncture point as a cylinder of ECM projecting to the surface of the skin: Heine Cylinder areas where nerve fibres and capillaries emerge from the ground substance to penetrate the skin at specific points Did basis research on autoregulatory processes in the ECM and on PGs and GAGs

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Mae-Wan Ho James Oschman

b 1940 … PhD Biophysics/Biology, University of Pittsburgh Worked in many research labs around the world Has researched and written about the peculiarities of the matrix and specifically on the energetic aspects 2000 “Energy Medicine: the Scientific Basis” 2003 “Energy Medicine in Therapeutics and Human Performance”

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James Oschman

“The Living Matrix” Extracellular Matrix Intra-cellular Matrix Nuclear Matrix Most toxins are stored in the ECM, but influence directly on the Intra- cellular Matrix and Nuclear Matrix

Living Matrix

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Books by James Oschman Synonyms of the ECM

• Le Terrain...Claude Bernard
• Mesenchyme...old medical terminology
• Connective Tissue...histological terminology
• Ground Regulating Substance..Pischinger
• Basic Bio-Regulating System..Lamers
• Extra-cellular Matrix... Current terminology
• Living Matrix...Oschman

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Matrix Summary

• ECM regulation is a functional unit that

includes the vascular pathway, the connective tissue cells, lymphatic system and the autonomic-nervous system

• ECM is the nexus for mediators to act both

centrally and peripherally

• ECM regulates substances entering the

system at the cellular level, it regulates the cell milieu itself and removes by-products of cellular activity

• Its regulatory capacity is involved in all

inflammatory reactions and is responsible for all vital activity of the organism

Matrix Summary 2

• The ECM determines the quality of the life
• f the cell and is therefore crucial for

healthy organ function

• Dysfunction of the ECM will result in

dysfunction of the cell

• Health and the patient’s quality of life is

directly related to the purity and efficient regulating processes in the living matrix

• Chronic diseases are the consequence of

the inability to effectively deal with toxins in the ECM

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Matrix Diagnosis

• TCM: Acupuncture Meridians
• EAV: Voll, Vega, Bio-Meridian, Mora,

Prognos, Asyra

• BTA: Biological Terrain Analysis

pH, redox, resistance

• pH Assessesment
• Thermography

Matrix Detoxification

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Toxin Accumulation according to Oschman

A  mechanical trapping B  ionic binding to charges on the matrix surface-+ cation toxin binds to a –charged hyaluronan C  hydrophobic and hydrophilic binding

pH and the Matrix

• In an acidic environment the matrix

regulation is disturbed

• This affects cellular metabolism by

increasing the % of anaerobic respiration thus increasing the production of lactic acid and further increasing the acidity

• The ECM acts as a store of toxins,
• Acidity prevents toxins from being

removed into the matrix and hence preventing cell damage

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pH and the Matrix 2

• The ECM stores toxins in the acidic state

and eliminates them in the alkaline state

• Abnormal ph is indication of a disruption in

the gut

• The acidity induces a loss of flexibility in

the matrix as the proteoglycans become more rigid

Diagnose Acidity in the Matrix using Saliva and Urine

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Restore Alkaline Balance Restore Alkaline Balance

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Oxidative Stress and the Matrix

• In the presence of increased oxidative

stress in the extracellular matrix, the free radicals can cause non-enzymatic breakdown of the GAGs.

• This can be a major factor in the

developmental pathology of certain chronic diseases such as cancer

Vitamin C and the Matrix

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Antigenicity and GAGs

• In their intact state, GAGs have low

antigenicity, but in abnormal states such as trauma and infection , the activated proteases break up the GAGs and the resultant debris can activate an autoimmune response

• The other way that collagen can induce

antigen activity is by non-enzymatic glycoslylation in hyperinsulinism and unregulated diabetes

Stress Response and the Matrix

• Short acting stimuli causes a temporary

depolarization of the matrix which in healthy tissues is immediately able to be repolarised

• Long lasting depolarization leads to

structural changes in the matrix with greater rigidity and becomes more gel-like and more metabolically inert

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Stress Response and the Matrix 2

• Chronic inflammation induces a state

where small short-acting stressors can produce an exaggerated long term reaction in the matrix and even more structural changes and loss of regulation

• These changes in the matrix are not just
• material. They modify resonance and
• scillation patterns of the tissues in

question and contribute to their losing phase coherence with the rest of the body

• The problem clinically, of course, is how to

diagnose and treat these short acting stimuli that come from hidden foci of infection or toxicity

Toxicity of the Matrix

• The matrix is the site of metabolite and

toxin accumulation and a buffer zone for stress

• Stress: physical, chemical, biologic,

electromagnetic, psychic

• A healthy matrix can regulate toxic stress

by serving as a temporary storage site

• An overburdened matrix becomes

deregulated and inflamed

• A chronically inflamed area of the matrix

develops into a FOCUS

• A Focus is an unresorbable particle in the

matrix

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FOCUS

• The primary cause is a chronic

inflammation in the matrix which may lead to secondary bacterial , viral or fungal infection and may or may not spread to

• ther cells and tissues
• The toxic and immunological load affects

tissues distant from its location and the general overall health condition

• May contribute to non-specific reactions

such as allergies and bio-energetic imbalances along acupuncture meridians

Causes of Foci

• Root canal and other dental procedures
• Chemotherapy
• Antibiotics
• Antifungals
• Surgery
• Environmental toxins
• Unresolved infections
• Vaccines
• Chronic myofascial tension

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Chronic Matrix Disease: Therapeutic Approach

• Treat the underlying cause of Matrix

dysregulation

• Provide therapy to re-establish regulation

capacity in the ECM:

• Regulate matrix ph
• Restore mitochondrial function
• Restore cytokine balance and other cell

communication factor balance

• Clear toxic metal, chemical and biological

toxins (dysbiosis)

• Improve lifestyle , diet, exercise and stress

management

• Find the chronic hidden focuses of infection

that are causing dysregulation of the matrix

Restore Matrix Regulation and pH

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Restore Mitochondrial Function Clear Toxic Metals

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Restore Cytokine Balance Clear Dysbiosis

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Scar Therapy

• Scars are an entrapment of non-

resorbable material from surgery

• Often interfere with meridian energetic flow

Treatment

• Inject along the scar with:
• Procaine
• Notakehl or Pleo Not
• Other homeopathic drainage ampoules

such as Pleo Form

Pleo Form: Anti-inflammatory Drainage

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Lymphatic System

Intimately connected to the Matrix Supports fluid dynamics for the matrix-water crystalline structure Immune activation, clearance and transport Waste material removal

Lymph-Matrix Connection

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Lymphatic Detoxification

Support and balance inflammatory processes Avoid suppressive remedies if possible Treat location of inflammation Support Drainage using: Lymph-A-Drop Apply Lymph Cream to relevant lymph nodes

Lymphatic Detox

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Systemic Detox Toxic Matrix Symptoms

• Fatigue
• Generalized body aches and sore organs
• Sleep disturbances
• Irritability, restlessness, and anxiety
• Memory problems and brain fog
• Headaches
• Sensitivity and paradoxical reactions to

nutritional supplements and medications

• Sympathetic nerve discharge such as

sweating, shivering, chills, itching and hot spells

• Nonspecific skin rashes

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Matrix Detox Therapy

• Assessment of the health of the Matrix using

Matrix imaging technology: BTA, Electro- dermal testing, CRT

• Diet therapy using alkaline diet and

appropriate nutraceuticals

• Treating underlying dysbiosis
• Herbal/homeopathic detoxification therapy

using specific homeopathic remedies targeted to matrix cleansing

• Lymph-matrix exercises such as the re-

bounder, skipping or vibration plate machines

• Steam ozone or infrared sauna therapy
• Matrix massage using either lymph drainage

massage or MRT